Navigation Links
Aspirin as Good as Plavix for Poor Leg Circulation: Study

By Steven Reinberg
HealthDay Reporter

TUESDAY, Feb. 21 (HealthDay News) -- Aspirin works as well as Plavix in patients with blocked leg arteries, a new European study finds.

People with the condition, called peripheral artery disease, often suffer from intermittent claudication, which is pain while walking because of decreased blood supply to the legs. Animal experiments had suggested that aspirin might block the growth of blood vessels that bypass blockages and help get more blood to leg tissue, the Swiss and German researchers said.

"Once again, we have shown that what happens in animals doesn't translate to humans," said Dr. Juan Zambrano, an assistant professor of cardiovascular medicine, coronary/endovascular and stem cell therapies at the University of Miami Miller School of Medicine.

Patients suffering from peripheral artery disease are also at increased risk of heart attack and stroke from blood clots traveling from the legs to the heart or brain, which is why these patients are given blood thinners such as Plavix (clopidogrel) or aspirin, explained Zambrano.

"Either aspirin or Plavix is acceptable as a good preventive measure to avoid heart attack or stroke in these patients," he said. "A lot of people favor aspirin because it's cheaper."

However, the most interesting part of this study to Zambrano was the role of exercise in improving walking distance and time.

"Something as simple as exercise can help improve claudication," he said. "Exercise is key and it doesn't matter how you treat the underlying condition, exercise is always going to help."

The report was published online Feb. 21 in the journal Cardiovascular and Cerebrovascular Disease.

For the study, a team led by Dr. Kurt Jaeger from University Hospital Basel in Switzerland, looked at the effectiveness of aspirin and Plavix in helping peripheral artery disease patients improve pain-free walking distance, which is a vital part of rehabilitation.

The researchers randomly assigned 229 patients to receive low-dose aspirin or Plavix, to see how they did during one hour walks.

Jaeger's group found that, after 12 weeks, people taking aspirin improved pain-free walking distance almost 40 percent and could walk 35 percent longer before pain made it too hard to continue.

For patients taking Plavix, there was a 33 percent improvement in walking distance and an almost 35 improvement in pain-free walking time, the researchers noted.

Walking is an important part of rehabilitation for peripheral artery disease patients. Walking can help increase blood flow to the legs and promote the growth of tiny blood vessels that help supply the leg with blood and oxygen.

It had been thought that aspirin wouldn't work because its anti-inflammatory properties could block the development of these tiny blood vessels that grow to get blood around the blockage.

"It seems that the anti-inflammatory properties of low-dose aspirin and its inhibiting effects on [the growth of new blood vessels] are not of clinical relevance for rehabilitation programs in intermittent claudication," the researchers concluded.

More information

For more on peripheral artery disease, visit the American Heart Association.

SOURCES: Juan P. Zambrano, M.D., assistant professor, cardiovascular medicine, coronary/endovascular and stem cell therapies, University of Miami Miller School of Medicine; Feb. 21, 2012, Cardiovascular and Cerebrovascular Disease

Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Experimental Drug Might Beat Aspirin in Preventing Repeat Strokes: Study
2. Low-Dose Aspirin to Prevent First Heart Attack or Stroke? Not So Fast
3. Could Daily Aspirin Harm Seniors Eyes?
4. Low-Dose Aspirin After Lung Clot Could Prevent Recurrence
5. Preoperative aspirin therapy can benefit cardiac surgery patients
6. Daily Aspirin May Help Prevent Colon Cancer for Those at High Risk
7. Scientists prove regular aspirin intake halves cancer risk
8. Even low-dose aspirin may increase risk of GI bleeding
9. No Proof That Aspirin Aids Conception, Review Shows
10. Stopping Daily Aspirin Boosts Heart Attack Risk: Study
11. Higher daily dose of aspirin could play key role in preventing heart attacks for those with diabetes
Post Your Comments:
Related Image:
Aspirin as Good as Plavix for Poor Leg Circulation: Study 
(Date:6/25/2016)... Beach, CA (PRWEB) , ... June 25, 2016 , ... ... UCLA with Magna Cum Laude and his M.D from the David Geffen School of ... Diego and returned to Los Angeles to complete his fellowship in hematology/oncology at the ...
(Date:6/25/2016)... Canada (PRWEB) , ... June 25, 2016 , ... Conventional ... pursuit of success. In terms of the latter, setting the bar too high can ... risk more than just slow progress toward their goal. , Research from ...
(Date:6/24/2016)... ... 24, 2016 , ... June 19, 2016 is World Sickle Cell Observance Day. ... the benefits of holistic treatments, Serenity Recovery Center of Marne, Michigan, has ... , Sickle Cell Disease (SCD) is a disorder of the red blood cells, which ...
(Date:6/24/2016)... MIAMI, Fla. (PRWEB) , ... June 24, 2016 , ... ... Florida Trend magazine’s 2016 Legal Elite. The attorneys chosen by their peers for this ... of Florida. , Seven Greenberg Traurig Shareholders received special honors as members of this ...
(Date:6/24/2016)... ... June 24, 2016 , ... Topical BioMedics, Inc, makers of Topricin and MyPainAway Pain Relief ... a minimum wage raise to $12 an hour by 2020 and then adjusting it yearly ... lost value of the minimum wage, assure the wage floor does not erode again, and ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... , June 24, 2016 According ... by Type (Standard Pen Needles, Safety Pen Needles), Needle ... GLP-1, Growth Hormone), Mode of Purchase (Retail, Non-Retail) - ... This report studies the market for the forecast period ... reach USD 2.81 Billion by 2021 from USD 1.65 ...
(Date:6/24/2016)... KNOXVILLE, Tenn. , June 24, 2016 /PRNewswire/ ... market providing less invasive and more durable cerebrospinal ... million in funding.  The Series-A funding is led ... the Lighthouse Fund, and other private investors.  Arkis, ... less-invasive neurosurgical instrumentation and the market release of ...
(Date:6/23/2016)... June 23, 2016 Any dentist who has made ... the current process. Many of them do not even offer ... difficulties and high laboratory costs involved. And those who ARE ... at such a high cost that the majority of today,s ... Dr. Parsa Zadeh , founder of Dental Evolutions Inc. ...
Breaking Medicine Technology: