Navigation Links
Aspirin May Stem Deaths From Colorectal Cancer
Date:8/11/2009

Study suggests a role for aspirin in prevention as well as treatment,,

TUESDAY, Aug. 11 (HealthDay News) -- Taking aspirin might not only reduce the risk of getting colorectal cancer, but it also might lower the odds of dying if you have it, new research suggests.

People with colorectal cancer who took aspirin regularly had a 29 percent lower risk for death from the cancer and a 21 percent lower risk for death from other causes, according to the research, reported in the Aug. 12 issue of the Journal of the American Medical Association.

After an average of about 12 years, 35 percent of the 549 people with colorectal cancer who took aspirin had died. That included about 15 percent whose death was attributed to the cancer.

Among 730 people with colorectal cancer who did not take aspirin, 39 percent had died, including 19 percent from the cancer.

The overall five-year survival rate was 88 percent for people who used aspirin, compared with 83 percent for those who did not. The 10-year survival rate was 74 percent for aspirin users and 69 percent for those who didn't use aspirin.

Researchers used data on 1,279 men and women with stage 1, 2 or 3 nonmetastatic colorectal cancer who were participating in two large studies, the Nurses Health Study that began in 1980 and the Health Professionals Follow-up Study that began in 1986.

"It's a pretty significant benefit and does suggest aspirin may have a role in treatment of patients with established colorectal cancer as well as for the prevention of developing initial tumors," said the study's lead author, Dr. Andrew Chan, a gastroenterologist at Massachusetts General Hospital and an assistant professor of medicine at Harvard Medical School.

Among 719 participants who had not used use aspirin before their cancer diagnosis, starting to take it once they'd been diagnosed was associated with a 47 percent lower risk for dying from the cancer and a 32 percent lower risk for dying prematurely from any cause.

The benefits linked to aspirin were especially evident among people with COX-2 positive tumors.

Previous research has shown that aspirin might reduce the chances of developing colorectal cancer tumors by inhibiting cyclooxygenase (COX-2) enzyme, Chan said. COX-2, which contributes to inflammation and cell proliferation, is overproduced in about 65 to 80 percent of human colorectal cancers, he said.

Researchers were able to test for the COX-2 overproduction in 459 people. Among those with what are known as "COX-2 positive" tumors, regular aspirin use after diagnosis was associated with a 61 percent lower risk for dying from colorectal cancer and 38 percent lower risk for premature death from any cause.

However, those who had "COX-2 negative" tumors and who took aspirin did not show decreased mortality, according to the study.

Nor did the researchers find much benefit for people who had been using aspirin before their cancer diagnosis. For them, continuing to take aspirin during and after their cancer treatment was not associated with a significant reduction in colorectal survival, Chan said.

"What that suggests is that those who developed cancer despite being on aspirin were probably developing cancers that were relatively resistant to aspirin," he said. "There are some tumors that are responsive to the effects of aspirin and some that are not."

Despite mounting evidence of aspirin's potential cancer-fighting properties, Chan stopped short of recommending that it be used to prevent or treat colorectal cancer.

Aspirin can cause side effects, including gastrointestinal bleeding. Further studies, including placebo-controlled trials of aspirin and other anti-inflammatory agents, are needed, he said.

"What we need before we make definitive clinical recommendations for all patients with colorectal cancer are large-scale, randomized, controlled trials to demonstrate benefits," Chan said. "That's the gold standard."

Dr. Alfred Neugut, a professor of medicine and epidemiology at Columbia University, who wrote an accompanying editorial, called the results "provocative."

"What makes this study more convincing than the average study was they measured COX-2 and were able to show that the aspirin helped those who were 'COX-2 positive' but had no significant effect on 'COX-2 negative' patients," Neugut said. "That's what's so elegant."

Neugut agreed that it was too soon to recommend aspirin as a means of preventing colorectal cancer. But an ongoing clinical trial sponsored by the National Cancer Center of Singapore might provide the necessary evidence, he added.

"Even though the study is very, very strong, most doctors would say we need a randomized trial," Neugut said. "If you're taking aspirin for cardiovascular disease prevention, you are probably getting a bonus in terms of it preventing colon cancer, but I wouldn't recommend it solely for colon cancer prevention."

More information

The American Cancer Society has more on colorectal cancer.



SOURCES: Andrew Chan, M.D., M.P.H., assistant professor, medicine, Harvard Medical School, and gastroenterologist, Massachusetts General Hospital, Boston; Alfred I. Neugut, M.D., Ph.D., professor, medicine and epidemiology, Herbert Irving Comprehensive Cancer Center, Columbia University, New York City; Aug. 12, 2009, Journal of the American Medical Association


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Discovery Health CME Explores the Benefits and Risks of Aspirin in Aspirin Therapy: Maximizing the Benefits
2. AUDIO from Medialink and Bayer: Is Your Pain Reliever Undermining Your Aspirin Therapy?
3. AUDIO from Medialink and Bayer: Lifesaving Benefits of Low-Dose Aspirin Therapy Maintained with Naproxen Sodium
4. New, No-Swallow Fasprin(R) Reduces Problems Associated with Daily Aspirin Regimen
5. Aspirin, Hormone Therapy Combo Can Shorten Lives of Prostate Cancer Patients
6. Aspirin Resistance Boosts Heart Risks in Cardiac Patients
7. Regular, long-term aspirin use reduces risk of colorectal cancer
8. Many stroke, heart attack patients may not benefit from aspirin
9. Women are treated less frequently than men with statins, aspirin and beta-blockers
10. Drugs like aspirin could reduce breast cancer and help existing sufferers
11. Corgenix to Exhibit AspirinWorks(R) Test at 2008 ACOFP Meeting in Denver
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Aspirin May Stem Deaths From Colorectal Cancer
(Date:10/13/2017)... ... 13, 2017 , ... Ellevate Network, the leading network for professional women, brought ... gender equality at their inaugural Summit in New York City in June. The event ... audience of over 3 million. To watch the Mobilize Women video, click here ...
(Date:10/13/2017)... ... October 13, 2017 , ... Coveros, a leader ... been awarded a contract by the Center for Medicare and Medicaid Services (CMS). ... the enterprise use of Agile methodologies in a consistent and high value manner ...
(Date:10/12/2017)... ... October 12, 2017 , ... CitiDent and San Francisco ... using cutting-edge Oventus O2Vent technology. As many as 18 million Americans are estimated ... in breathing. Oral appliances can offer significant relief to about 75 percent of ...
(Date:10/12/2017)... ... October 12, 2017 , ... The American College of Medical Informatics (ACMI) ... FACMI, during the Opening Session of AMIA’s Annual Symposium in Washington, D.C. AMIA’s ... Morris F. Collen, a pioneer in the field of medical informatics, this prestigious award ...
(Date:10/12/2017)... ... October 12, 2017 , ... HMP , a leader in healthcare ... Folio Magazine Eddie Digital Award for ‘Best B-to-B Healthcare Website.’ Winners were announced during ... , The annual award competition recognizes editorial and design excellence across a range of ...
Breaking Medicine News(10 mins):
(Date:10/7/2017)... --  Provista, a proven leader in the supply ... power, today announced a new resource area on Provistaco.com ... is the online home for case studies, articles on ... releases, slideshows and events. ... at their fingertips, viewers can also watch short videos ...
(Date:10/4/2017)... WESTWOOD, Mass. , Oct. 4, 2017  According to the Centers ... by the end of October . PhysicianOne Urgent Care is helping communities ... Westchester, NY , by offering no-cost* flu shots through ... , as mandated by certain health insurance regulations. ... The best time to get a flu shot is by ...
(Date:10/2/2017)... INDIANAPOLIS , Oct. 2, 2017  Eli Lilly ... its financial results for the third quarter of 2017 ... a conference call on that day with the investment ... performance. The conference call will begin at ... public can access a live webcast of the conference ...
Breaking Medicine Technology: