Navigation Links
Aspirin May Boost Breast Cancer Survival
Date:2/16/2010

Risk of death, recurrence halved for those who took it, study finds

TUESDAY, Feb. 16 (HealthDay News) -- A new study of more than 4,000 women who were diagnosed with breast cancer shows that taking aspirin appears to significantly increase survival and reduce the risk of recurrence.

"Women who took aspirin were 50 percent less likely to die from breast cancer [during the study follow-up period] than those who did not take it," said study author Dr. Michelle Holmes, an associate professor of medicine and epidemiology at Harvard Medical School and School of Public Health, in Boston.

The study is published online Feb. 16 in the Journal of Clinical Oncology.

The 50 percent reduction is the overall finding when comparing to users to nonusers, she said. "Statistically, the women who took it more days per week had a higher risk reduction," Holmes noted. For instance, those who took it six to seven days a week had a 64 percent reduction in risk of death during the follow-up. For some reason, those who took aspirin two to five days a week had an even greater risk reduction, 71 percent, Holmes found.

But the most important finding, in her view, was the overall 50 percent reduction. She didn't have access to doses, just number of days a week the women took aspirin, she noted.

Aspirin use also reduced the risk of recurrence of the cancer in similar fashion.

"It is a surprisingly strong effect," Holmes said, though she acknowledged that it was an observational study and does not establish definitive cause and effect.

Exactly how aspirin confers a risk reduction is not known, Holmes said. But the new research is in line with some previous studies. "We're appreciating more and more that cancer is an inflammatory disease, and aspirin is an anti-inflammatory," she said.

Aspirin might lower estrogens in the blood or might prevent early spread of cancer, the researchers speculated.

For the study, Holmes and her colleagues evaluated aspirin use among women at least one year after having been diagnosed with breast cancer. The women, diagnosed with stage 1, 2 or 3 breast cancer between 1976 and 2002, were all participants in the Nurses' Health Study.

During the follow-up, which went until a woman's death or June 2006, 341 women died of breast cancer and 400 had distant recurrences, or metastatic disease.

Aspirin would never be a substitute for recommended cancer treatments, Holmes said. And aspirin does have negative effects in some. "It can cause bleeding of the GI tract," she noted.

More study is needed, Holmes said, but for now, "if a woman has breast cancer and is taking aspirin for other reasons [such as arthritis or pain], she may take some comfort in knowing she might be doing something to help prevent her breast cancer from recurring."

"This is the largest study of aspirin use and breast cancer recurrence and survival to date," said Eric Jacobs, director of pharmacoepidemiology for the American Cancer Society. Previous research has produced mixed findings, he noted.

"While the results from this study are exciting, there are some important caveats," he said. Like Holmes, he noted that the findings do not prove cause and effect.

"As noted by the study authors, it is possible that survival results could have been influenced by women with recurrent breast cancer being advised to stop taking aspirin during chemotherapy, resulting in an overestimate of any benefit of aspirin use," Jacobs said.

Both Holmes and Jacobs agreed that it's premature to suggest that breast cancer survivors take aspirin with an aim of reducing breast cancer recurrence or death from the disease. Women should talk to their doctor about what's best for them, they said.

More information

The American Cancer Society has more about breast cancer.



SOURCES: Michelle Holmes, M.D., associate professor, medicine and epidemiology, Harvard Medical School and School of Public Health, and associate physician, Brigham & Women's Hospital, Boston; Eric Jacobs, Ph.D., director, pharmacoepidemiology, American Cancer Society, Atlanta; Feb. 16, 2010, Journal of Clinical Oncology


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Discovery Health CME Explores the Benefits and Risks of Aspirin in Aspirin Therapy: Maximizing the Benefits
2. AUDIO from Medialink and Bayer: Is Your Pain Reliever Undermining Your Aspirin Therapy?
3. AUDIO from Medialink and Bayer: Lifesaving Benefits of Low-Dose Aspirin Therapy Maintained with Naproxen Sodium
4. New, No-Swallow Fasprin(R) Reduces Problems Associated with Daily Aspirin Regimen
5. Aspirin, Hormone Therapy Combo Can Shorten Lives of Prostate Cancer Patients
6. Aspirin Resistance Boosts Heart Risks in Cardiac Patients
7. Regular, long-term aspirin use reduces risk of colorectal cancer
8. Many stroke, heart attack patients may not benefit from aspirin
9. Women are treated less frequently than men with statins, aspirin and beta-blockers
10. Drugs like aspirin could reduce breast cancer and help existing sufferers
11. Corgenix to Exhibit AspirinWorks(R) Test at 2008 ACOFP Meeting in Denver
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/22/2017)... PITTSBURGH, PA (PRWEB) , ... September 22, 2017 ... ... as soon as possible, and they often saves lives. However, if one isn’t ... order to widen the availability of defibrillation, I came up with this idea," ...
(Date:9/22/2017)... ... ... After a long health ordeal that involved a number ... with assistance from CreditAssociates. CreditAssociates provides debt relief and debt settlement programs that ... is one of the satisfied clients who expressed their appreciation for the excellent ...
(Date:9/22/2017)... ... September 22, 2017 , ... Happy Living’s mission - ... - carries it into the entertaining and delicious worlds of theatre and wines. ... of Happy Living) convinced him to turn his play into a book. The Greener ...
(Date:9/22/2017)... (PRWEB) , ... September 22, 2017 , ... ... a nutritional supplement produced by Native Remedies that helps promote pancreatic health and ... for many individuals. However, some prescription-based approaches can have negative side effects, and ...
(Date:9/22/2017)... ... September 22, 2017 , ... ... brush more effectively even on the go. Their electric toothbrushes aggressively attack oral ... inflammation, with UV sanitizing technology. Combining leading edge Enke technology with a premium ...
Breaking Medicine News(10 mins):
(Date:9/19/2017)... , Sept. 19, 2017   ZirMed Inc ., ... analytics, today announced that it has been ranked #1 by ... Black Book™ Rankings 2017 User Survey. ZirMed was recognized ... for large hospitals and medical centers over 200 beds and ... Book,s healthcare technology user survey history. ...
(Date:9/12/2017)... NEW YORK , Sept. 12, 2017   EcoVadis , the ... chains, has published the first annual edition of its Global CSR Risk ... 20,400 companies evaluated by EcoVadis, based on Scorecard Ratings that analyzed nearly ... ... Performance Index ...
(Date:9/9/2017)... -- Dealmed Medical Supplies, New York City,s ... drugs, vaccines, and specialty medical products and services, announced ... acquire Vantage Medical Supplies, a major distributor of medical ... York . ... practices, will operate under the Dealmed name as of ...
Breaking Medicine Technology: