Navigation Links
Aspirin May Boost Breast Cancer Survival
Date:2/16/2010

Risk of death, recurrence halved for those who took it, study finds

TUESDAY, Feb. 16 (HealthDay News) -- A new study of more than 4,000 women who were diagnosed with breast cancer shows that taking aspirin appears to significantly increase survival and reduce the risk of recurrence.

"Women who took aspirin were 50 percent less likely to die from breast cancer [during the study follow-up period] than those who did not take it," said study author Dr. Michelle Holmes, an associate professor of medicine and epidemiology at Harvard Medical School and School of Public Health, in Boston.

The study is published online Feb. 16 in the Journal of Clinical Oncology.

The 50 percent reduction is the overall finding when comparing to users to nonusers, she said. "Statistically, the women who took it more days per week had a higher risk reduction," Holmes noted. For instance, those who took it six to seven days a week had a 64 percent reduction in risk of death during the follow-up. For some reason, those who took aspirin two to five days a week had an even greater risk reduction, 71 percent, Holmes found.

But the most important finding, in her view, was the overall 50 percent reduction. She didn't have access to doses, just number of days a week the women took aspirin, she noted.

Aspirin use also reduced the risk of recurrence of the cancer in similar fashion.

"It is a surprisingly strong effect," Holmes said, though she acknowledged that it was an observational study and does not establish definitive cause and effect.

Exactly how aspirin confers a risk reduction is not known, Holmes said. But the new research is in line with some previous studies. "We're appreciating more and more that cancer is an inflammatory disease, and aspirin is an anti-inflammatory," she said.

Aspirin might lower estrogens in the blood or might prevent early spread of cancer, the researchers speculated.

For the study, Holmes and her colleagues evaluated aspirin use among women at least one year after having been diagnosed with breast cancer. The women, diagnosed with stage 1, 2 or 3 breast cancer between 1976 and 2002, were all participants in the Nurses' Health Study.

During the follow-up, which went until a woman's death or June 2006, 341 women died of breast cancer and 400 had distant recurrences, or metastatic disease.

Aspirin would never be a substitute for recommended cancer treatments, Holmes said. And aspirin does have negative effects in some. "It can cause bleeding of the GI tract," she noted.

More study is needed, Holmes said, but for now, "if a woman has breast cancer and is taking aspirin for other reasons [such as arthritis or pain], she may take some comfort in knowing she might be doing something to help prevent her breast cancer from recurring."

"This is the largest study of aspirin use and breast cancer recurrence and survival to date," said Eric Jacobs, director of pharmacoepidemiology for the American Cancer Society. Previous research has produced mixed findings, he noted.

"While the results from this study are exciting, there are some important caveats," he said. Like Holmes, he noted that the findings do not prove cause and effect.

"As noted by the study authors, it is possible that survival results could have been influenced by women with recurrent breast cancer being advised to stop taking aspirin during chemotherapy, resulting in an overestimate of any benefit of aspirin use," Jacobs said.

Both Holmes and Jacobs agreed that it's premature to suggest that breast cancer survivors take aspirin with an aim of reducing breast cancer recurrence or death from the disease. Women should talk to their doctor about what's best for them, they said.

More information

The American Cancer Society has more about breast cancer.



SOURCES: Michelle Holmes, M.D., associate professor, medicine and epidemiology, Harvard Medical School and School of Public Health, and associate physician, Brigham & Women's Hospital, Boston; Eric Jacobs, Ph.D., director, pharmacoepidemiology, American Cancer Society, Atlanta; Feb. 16, 2010, Journal of Clinical Oncology


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Discovery Health CME Explores the Benefits and Risks of Aspirin in Aspirin Therapy: Maximizing the Benefits
2. AUDIO from Medialink and Bayer: Is Your Pain Reliever Undermining Your Aspirin Therapy?
3. AUDIO from Medialink and Bayer: Lifesaving Benefits of Low-Dose Aspirin Therapy Maintained with Naproxen Sodium
4. New, No-Swallow Fasprin(R) Reduces Problems Associated with Daily Aspirin Regimen
5. Aspirin, Hormone Therapy Combo Can Shorten Lives of Prostate Cancer Patients
6. Aspirin Resistance Boosts Heart Risks in Cardiac Patients
7. Regular, long-term aspirin use reduces risk of colorectal cancer
8. Many stroke, heart attack patients may not benefit from aspirin
9. Women are treated less frequently than men with statins, aspirin and beta-blockers
10. Drugs like aspirin could reduce breast cancer and help existing sufferers
11. Corgenix to Exhibit AspirinWorks(R) Test at 2008 ACOFP Meeting in Denver
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/28/2016)... ... April 28, 2016 , ... Metabolic Nutrition ... at this week’s 2016 Europa Games Get Fit and Sports Expo in ... the Europa Orlando Expo coming up April 29-30, was selected as the perfect event ...
(Date:4/28/2016)... D.C. (PRWEB) , ... April 28, 2016 , ... The ... and Prevention (CDC) has established an ICD-10-CM code for sarcopenia, giving it recognition for ... the medical community effective October 1, 2016. , Sarcopenia is defined as a combination ...
(Date:4/28/2016)... (PRWEB) , ... April 28, ... ... an invitation to those affected by a health insurance co-operative bankruptcy to ... proprietary process, individuals can receive over 1,500 FDA-approved prescription medications from over ...
(Date:4/28/2016)... ... April 28, 2016 , ... Today ... the Protocol Calendar Exchange , is officially open to all sponsors in ... available for sites to download into their clinical trial management system (CTMS), which ...
(Date:4/28/2016)... , ... April 28, 2016 , ... ... Chief Medical Officer at the Steadman Philippon Research Institute in Vail, Colorado, ... to raise awareness about the debilitating and costly musculoskeletal disorders that are ...
Breaking Medicine News(10 mins):
(Date:4/28/2016)... April 28, 2016   Click here for ... Inc. (NYSE: DPLO), the nation,s largest independent specialty ... definitive agreement to acquire Valley Campus Pharmacy, Inc., ... a leading specialty pharmacy that provides individualized patient ... . In 2015, TNH generated approximately $400 ...
(Date:4/28/2016)... NEW YORK , April 28, 2016 /PRNewswire/ ... will notably complement the company,s valve repair and ... the move also places Abbott more firmly into ... one of the fastest growing device areas, with ... to its recent report,  Advanced Remote Patient ...
(Date:4/28/2016)... Research and Markets has announced the addition ... report to their offering.      (Logo: ... plastic surgery products market is expected to grow at ... ,The growing adoption of laser in aesthetics is another ... Lasers are used to treat a broad range of ...
Breaking Medicine Technology: