Navigation Links
Aspirin: Scientists believe cancer prevention benefits outweigh harms
Date:8/5/2014

New research from Queen Mary University of London (QMUL) reveals taking aspirin can significantly reduce the risk of developing and dying from the major cancers of the digestive tract, i.e. bowel, stomach and oesophageal cancer.

For the first time, scientists have reviewed all the available evidence from many studies and clinical trials assessing both the benefits and harms of preventive use of aspirin. Conclusions of the study, funded by Cancer Research UK among others, are published today in the leading cancer journal Annals of Oncology*.

The researchers, led by Professor Jack Cuzick, Head of QMUL's Centre for Cancer Prevention (London, UK), found taking aspirin for 10 years could cut bowel cancer cases by around 35% and deaths by 40%. Rates of oesophageal and stomach cancers were cut by 30% and deaths from these cancers by 35-50%.

To reap the benefits of aspirin, the evidence shows people need to start taking a daily dose of 75-100 mg for at least five years and probably 10 years between the ages of 50 and 65. No benefit was seen whilst taking aspirin for the first three years, and death rates were only reduced after five years.

However, the research also warns taking aspirin long-term increases the risk of bleeding from the digestive tract, e.g. stomach bleeding. Amongst 60-year-old individuals who take daily aspirin for 10 years, the risk of digestive tract bleeds increases from 2.2% to 3.6%, and this could be life-threatening in a very small proportion (less than 5%) of people.

Overall, rates of serious or fatal gastrointestinal bleeding are very low under the age of 70, but increased sharply after that age. Another side effect of aspirin use is peptic ulcer, the risk of which is increased by 30-60%.

The study also uncovers uncertainty over the most appropriate dose of aspirin required to maximize the benefit / harm ratio, with doses varying between 75 mg to 325mg a day in different clinical trials and studies. It is also not clear whether taking aspirin for longer than 10 years will result in greater benefits.

Professor Jack Cuzick, Queen Mary University of London, comments: "It has long been known that aspirin one of the cheapest and most common drugs on the market can protect against certain types of cancer. But until our study, where we analysed all the available evidence, it was unclear whether the pros of taking aspirin outweighed the cons.

"Whilst there are some serious side effects that can't be ignored, taking aspirin daily looks to be the most important thing we can do to reduce cancer after stopping smoking and reducing obesity, and will probably be much easier to implement."

"Our study shows that if everyone aged between 50-65 started taking aspirin daily for at least 10 years, there would be a 9% reduction in the number of cancers, strokes and heart attacks overall in men and around 7% in women. The total number of deaths from any cause would also be lower, by about 4% over a 20-year period. The benefits of aspirin use would be most visible in the reduction in deaths due to cancer.

"The risk of bleeding depends on a number of known factors which people need to be aware of before starting regular aspirin and it would be advisable to consult with a doctor before embarking on daily medication."

Further research is now needed to define more clearly who will benefit most greatly from taking aspirin and who is most at risk of the bleeding side effects.


'/>"/>

Contact: Charli Scouller
c.scouller@qmul.ac.uk
020-788-27943
Queen Mary, University of London
Source:Eurekalert

Related medicine news :

1. Scientists Shed Light on Link Between Depression, Dementia
2. Scientists pinpoint bladder cancer patients who could benefit from tumor-softening treatment
3. Scientists to study hereditary breast cancer to find BRCA1 treatment
4. Drexel Scientists Develop Compound to Stop Spread of Metastatic Cancer Cells
5. Scientists test nanoparticle alarm clock to awaken immune systems put to sleep by cancer
6. Brain Tumor Causes and Risk Factors Elude Scientists
7. Brain tumor causes and risk factors elude scientists
8. Mount Sinai Scientists and International Team Shed New Light on Schizophrenia in Largest Genomic Study Published to Date
9. NIH-supported scientists demonstrate very early formation of SIV reservoir
10. Scientists Snipped HIV Out of Human DNA
11. Scientists Discover New Way to Make Human Platelets
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/24/2017)... ... February 24, 2017 , ... Houston ... options at his office, Antoine Dental Center. Currently, patients can get single dental ... may apply, but patients can learn more about these offers by contacting Antoine ...
(Date:2/24/2017)... ... 24, 2017 , ... WHAT: , The New Jersey Tech ... well as advocacy for the state and region‘s technology businesses, hosted their 2017 ... Council's Innovation Forecast event highlights innovation throughout the region from small to large ...
(Date:2/24/2017)... ... February 24, 2017 , ... Dr. ... has officially announced the appointment of Peter A. Bell, DO, MBA, HPF, FACOEP-dist., ... (LUCOM), beginning April 10. Dr. Bell comes to Liberty from the Ohio ...
(Date:2/24/2017)... York, NY (PRWEB) , ... February 24, 2017 , ... ... “Security needs to be a top priority because it’s not if you will be ... online safety, especially when it comes to digital health care. , Improvements in auditing ...
(Date:2/24/2017)... Texas (PRWEB) , ... February 24, 2017 , ... ... to The Medical Center at Craig Ranch building at 8080 State Highway 121, Suite ... Medical District with easy access to Highway 121. , As the practice has grown, ...
Breaking Medicine News(10 mins):
(Date:2/24/2017)... February 24, 2017 Following receiving ... Israel , s AMAR is a major ... 250 M w ound care market in ... BST for inclusion in the National Health Basket ...   E-QURE Corp. (OTCQB: EQUR), a leader ...
(Date:2/24/2017)... 24, 2017 Research and Markets has announced the ... Industry Forecast to 2025" report to their offering. ... The Global Empty Capsules Market is poised ... to reach approximately $2.9 billion by 2025. This industry ... on global as well as regional levels presented in the research scope. ...
(Date:2/24/2017)... 24, 2017 Physician General Dr. Rachel ... Programs Jennifer Smith commended South Central EMS ... and using naloxone, a life-saving overdose reversal drug. The ... recovery specialist and overdose survivor who was saved due ... "A significant part of fighting the opioid epidemic ...
Breaking Medicine Technology: