Navigation Links
Aspirin, Hormone Therapy Combo Can Shorten Lives of Prostate Cancer Patients
Date:12/26/2007

First, prescribed to protect the heart, can lead to halting of cancer therapy, report says

WEDNESDAY, Dec. 26 (HealthDay News) -- Men undergoing hormone therapy for prostate cancer who take baby aspirin to protect their heart run a significantly higher risk of dying, new research suggests.

Apparently, baby aspirin interacts with the hormone therapy to elevate liver-function test levels. The end result is the man must stop potentially lifesaving hormone therapy.

The findings are contained in a letter published in the Dec. 27 issue of the New England Journal of Medicine.

Hormonal therapy, which involves reducing levels of male hormones called androgens, is a common treatment for prostate cancer, but it can raise the risk of a heart attack. So men who are older or have known coronary risk factors such as diabetes or smoking usually take baby aspirin while undergoing hormone therapy because aspirin helps prevent blood clots.

"Aspirin is being prescribed more widely for these men so we looked to see if there was any effect of aspirin on prostate cancer outcomes," said lead researcher Dr. Anthony V. D'Amico, chief of the division of genitourinary radiation oncology at Brigham & Women's Hospital and the Dana-Farber Cancer Institute, both in Boston.

The authors analyzed data on 206 men with localized prostate cancers who were already enrolled in a trial to compare radiation therapy alone with radiation therapy plus hormone therapy. The hormone therapy included six months of the anti-androgen flutamide.

Flutamide had a tendency to elevate results of liver-function tests. Although these elevations were benign, they meant hormonal therapy had to be stopped, at least temporarily, D'Amico explained.

Men who didn't complete six months of hormone therapy were 3.5 times more likely to die compared to men who got the full course of hormone therapy.

"It was sort of a paradoxical finding," D'Amico said. "Men who were taking aspirin were more likely to die of prostate cancer than those who were not, which didn't make sense at first."

But when the researchers delved deeper, they realized that the men who were taking aspirin were more likely to have to stop hormone therapy.

"Liver function is something you monitor" when undergoing hormone therapy, D'Amico explained. "When the tests elevate, you take the patient off of hormone therapy till the tests normalize, then you restart the therapy."

An explanation for this interaction comes from previous animal studies, D'Amico said. For rabbits that take aspirin while undergoing hormone therapy, that aspirin is magnified 100-fold in terms of how much gets into the blood. "That makes it a toxic dose of aspirin," he explained.

Although such a study can't establish a cause-and-effect association, it does appear likely, D'Amico said.

"If a man is taking baby aspirin just to prevent heart disease, we would ask the oncologist to ask the primary-care physician if he could come off the baby aspirin for the months while he's getting cancer therapy. If the aspirin is just for prevention, this is probably the simplest thing to do," he said. "But if the patient is on aspirin because he absolutely needs it, then they'd have to treat the prostate cancer without hormone therapy. It really comes down to a trade-off: How much do they need the aspirin versus how much do they need hormonal therapy, and there are alternative treatments for prostate cancer."

More information

The American Cancer Society has more on prostate cancer and hormone therapy.



SOURCES: Anthony V. D'Amico, M.D., Ph.D., chief, division of genitourinary radiation oncology, Brigham & Women's Hospital and Dana-Farber Cancer Institute, Boston; Dec. 27, 2007, New England Journal of Medicine


'/>"/>
Copyright©2007 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Drop in breast cancer incidence linked to hormone use, not mammograms
2. Researchers develop long-lasting growth hormone
3. One of the Largest Post-WHI Physician Surveys Shows More Education is Needed: Patient Misinformation About Hormone Therapy Remains High
4. Less than one-third of women aware of landmark hormone therapy study, Stanford researcher finds
5. Most Women Unaware of Hormone Replacement Study
6. Survival data presented from phase II study of hormone-resistant prostate cancer patients
7. Hormone May Play Key Part in Creating Memories
8. Hormone Therapy for Prostate Cancer Linked to Heart Risks
9. Wyeth to Appeal Nevada Hormone Therapy Trial Verdict
10. New data on hormone therapy must lead to re-evaluation of official guidelines
11. From Hot Flashes to Breast Cancer: ZRT Labs Hormone Testing Catches On As Women Consider Safer, More Natural Options.
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Aspirin, Hormone Therapy Combo Can Shorten Lives of Prostate Cancer Patients 
(Date:12/7/2016)... ... 2016 , ... ODU, a worldwide leader in designing ... advanced highly customizable contact technology solutions. , ODU Single Contact Technology portfolio includes: ... for a wide range of applications that require customization from industries like emobility, ...
(Date:12/7/2016)... ... December 07, 2016 , ... Augustine ... services to families and business owners in the greater Dallas metropolitan area, is ... Dallas Fallen Officer Foundation. , Established in 2009 by active police professionals in ...
(Date:12/7/2016)... ... 2016 , ... A. Kevin Spann Insurance, a New York-based firm offering insurance ... launching a charity drive to raise funds that will benefit the Marine Corps League. ... and Navy FMF Corpsmen. Working closely with the MCL, the A. Kevin Spann team ...
(Date:12/7/2016)... ... December 07, 2016 , ... The ... its fully redesigned website, which launched October 17, 2016, features comprehensive information regarding ... and easy-to-navigate layout. Visitors and patients can discover the latest clinical dermatology treatments ...
(Date:12/7/2016)... Dallas, TX (PRWEB) , ... December 07, 2016 ... ... service based in Dallas, Texas, is condemning "scam operations" carried out by unethical ... to bring these scam operations to a halt. According to Texas Premier Locksmith, ...
Breaking Medicine News(10 mins):
(Date:12/7/2016)... -- REPORT OBJECTIVES The report "SPF ... on a market segment, based on geography. Market ... the report. The primary objectives of this report ... through detailed segmentation, 2) market size and forecasts, ... market situation, trends, 3) detailed analysis of current ...
(Date:12/7/2016)... YORK , Dec. 7, 2016 ... report on pulmonary drugs studies the current as ... The stakeholders of this report include companies and ... various pulmonary/respiratory drugs and/or drug-device combinations as well ... This report comprises an elaborate executive summary along ...
(Date:12/7/2016)... DIEGO , Dec. 7, 2016   Arena ... announced that it has completed enrollment in the ralinepag ... receptor agonist targeting the prostacyclin pathway for the treatment ... 60 patients at sites globally. "This marks ... is evidence of our strategic focus on our pipeline," ...
Breaking Medicine Technology: