Navigation Links
Asian spice could reduce breast cancer risk in women exposed to hormone replacement therapy
Date:7/13/2009

COLUMBIA, Mo. Previous studies have found that postmenopausal women who have taken a combined estrogen and progestin hormone replacement therapy have increased their risk of developing progestin-accelerated breast tumors. Now, University of Missouri researchers have found that curcumin, a popular Indian spice derived from the turmeric root, could reduce the cancer risk for women after exposure to hormone replacement therapy.

"Approximately 6 million women in the United States use hormone replacement therapy to treat the symptoms of menopause," said Salman Hyder, the Zalk Endowed Professorship in Tumor Angiogenesis and professor of biomedical sciences in the College of Veterinary Medicine and the Dalton Cardiovascular Research Center. "This exposure to progestin will predispose a large number of post-menopausal women to future development of breast cancer. The results of our study show that women could potentially take curcumin to protect themselves from developing progestin-accelerated tumors."

In the study, researchers found that curcumin delayed the first appearance, decreased incidence and reduced multiplicity of progestin-accelerated tumors in an animal model. Curcumin also prevented the appearance of gross morphological abnormalities in the mammary glands. In previous studies, MU researchers showed that progestin accelerated the development of certain tumors by increasing production of a molecule called VEGF that helps supply blood to the tumor. By blocking the production of VEGF, researchers could potentially reduce the proliferation of breast cancer cells. Curcumin inhibits progestin-induced VEGF secretion from breast cancer cells, Hyder said.

"Curcumin and other potential anti-angiogenic compounds should be tested further as dietary chemopreventive agents in women already exposed to hormone replacement therapy containing estrogen and progestin in an effort to decrease or delay the risk of breast cancer associated with combined hormone replacement therapy," Hyder said.


'/>"/>

Contact: Kelsey Jackson
JacksonKN@missouri.edu
573-882-8353
University of Missouri-Columbia
Source:Eurekalert

Related medicine news :

1. Conventional prognostic factors fail to explain better prostate cancer survival in most Asian men
2. West Clinic Continues Expansion Into Asian Market With Opening of Shanghai Cancer Center
3. FalconStor Software Inc. Founders Make Multi-Million Dollar Donation to North Shore-LIJ Health System for Asian Community Health Center in Flushing
4. Emerging therapies with a focus on Asian populations mark the AACR Centennial Conference
5. Mannatech Hosts Australasian Convention
6. Non-Caucasians at higher risk for severe metastatic breast cancer pain
7. Chinas biotech industry: An Asian dragon is growing
8. Access Licenses MuGard(TM) to RHEI Pharmaceuticals, a Leading Specialty Pharmaceutical Company for Distribution in China and Certain Other Southeast Asian Countries
9. Asian women at risk for arterial defect
10. Carringtons DelSite Drug Delivery Technology Granted Patent From Eurasian Patent Office
11. African Americans Show Facial Aging in Eyes Earlier Than Caucasians
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/21/2017)... ... 2017 , ... PIXACORE , an independent full-service agency with a decade ... of the year by MM&M. , This is the first time PIXACORE has made ... the agency. PIXACORE’s newfound recognition reflects its steady trajectory of growth and recent ...
(Date:8/21/2017)... ... August 21, 2017 , ... The Industrial Designers Society of America ... Ceremony and Gala on Aug. 19, 2017 in Atlanta, GA—revealing which 25 designs ... prestigious and rigorous design competitions. See all the winners at http://www.idsa.org/awards/idea/gallery . , ...
(Date:8/20/2017)... ... , ... Are you an adult with gluten intolerance or Celiac disease living ... in participating in a research study that focuses on family interactions when dealing with ... relational aspects of adults who have gluten sensitivities who cohabitate with other adults who ...
(Date:8/19/2017)... ... 18, 2017 , ... President Donald Trump signed into law ... for greater public access to over-the-counter (OTC) hearing aids. , The measure enables ... without being seen by a certified and licensed audiologist. , “The American ...
(Date:8/19/2017)... ... August 19, 2017 , ... Yesterday, the President of ... saying there are two sides. There are not two sides to hatred, bigotry, discrimination, ... violence and prejudice, and the NPEIV stands against all forms of such hatred and ...
Breaking Medicine News(10 mins):
(Date:8/2/2017)... , Aug. 2, 2017 CaryRx, a next-generation ... day delivery service for patients in the Washington ... traditional retail pharmacy by providing delivery of medications through the ... for future delivery or delivered within one hour to any ... are excited to bring this invaluable service to ...
(Date:7/31/2017)... 7D Surgical, developer of ground breaking surgical navigation ... Surgical System to support its strategic sales plan in ... and Virginia.  7D Surgical has entered into an exclusive sales ... medical facilities within those markets. ... Spartan Medical Purchases ...
(Date:7/27/2017)... -- West Pharmaceutical Services, Inc. (NYSE: WST ) ... and updated financial guidance for the full-year 2017. ... Reported net sales of $397.6 million, a ... sales at constant currency (organic) grew by 3.9%. ... to $0.60 in the prior-year quarter. Second-quarter 2017 adjusted ...
Breaking Medicine Technology: