Asian non-small cell lung cancer (NSCLC) patients survive longer than Caucasians no matter how many drugs are given in a first-line setting, and the effect was apparent both before and after the introduction of targeted therapies in the early 2000s, according to research published in the June issue of the Journal of Thoracic Oncology.
"It is recognized Asian patients with a common type of lung cancer, the non-small cell type, have a better survival than Caucasian patients when treated with chemotherapy," said Dr. Ross Soo, senior consultant in the Department of Haematology-Oncology at the National University Hospital in Singapore. "What wasn't known previously was whether this effect was seen in patients given just one or a combination of drugs. Furthermore, the improved survival could have been due to the better chance of targeted therapy working in Asians.
"We analyzed studies published in the past 35 years in which chemotherapy was given to patients in the advanced stage," Dr. Soo said. "We found Asian patients indeed had a longer survival and also a higher chance of tumor shrinkage regardless of the number of chemotherapy drugs given in the first-line setting. We also found Asian patients lived longer than Caucasian patients in the era both before and after the use of targeted therapy such as gefitinib and erlotinib. These findings may impact on the design and conduct of international lung cancer trials as more Asian countries are now participating in such studies."
Researchers analyzed 191 randomized controlled trials published between 1975 and 2010 involving 48,369 patients (6,806 Asian and 41,563 white).
For all drug regimens across those 35 years, Asian patients experienced median overall survival (OS) of 10.1 months while white patients' overall survival was 8.0 months. For monotherapy, the median OS was 9.9 months for Asians and 6.8 months for whites. For platinum-based doublets, median OS was 10.4 months
|Contact: Rene McGaw|
International Association for the Study of Lung Cancer