Navigation Links
Ascenta Therapeutics Receives Clearance to Initiate Clinical Trials With AT-406
Date:9/10/2009

MALVERN, Pa., Sept. 10 /PRNewswire/ -- Ascenta Therapeutics announced today that following the approval by the U.S. Food and Drug Administration (FDA) of its Investigational New Drug (IND) Application for AT-406, an orally-active, small molecule, multi-IAP antagonist, the company will initiate a Phase I clinical trial in patients with advanced cancer during the fourth quarter of 2009.

(Logo: http://www.newscom.com/cgi-bin/prnh/20090227/PH75873LOGO )

"We are very pleased to be moving our second oral, pro-apoptotic agent into human clinical trials," said Mel Sorensen, MD, CEO of Ascenta Therapeutics. "AT-406 has shown promising anti-tumor activity in a variety of pre-clinical models and we are eager to lay the groundwork for further clinical development with the results of this 'first-in-man' study."

The multi-center, single-agent, open-label, Phase I accelerated dose escalation study will evaluate safety and determine the maximum tolerated dose and optimal dosing schedule of AT-406 in patients with advanced lymphomas and solid tumors. Secondary endpoints will include pharmacodynamic and pharmacokinetic parameters and evidence of anti-tumor activity.

About AT-406

AT-406 is an orally-active, small molecule drug designed to promote programmed cell death (apoptosis) in tumor cells by blocking the activity of at least three "inhibitors of apoptosis proteins" or IAPs (including XIAP, c-IAP1, and c-IAP2) to create conditions in which apoptosis can proceed. As such, AT-406 is considered a multi-IAP antagonist. IAPs are key components of the complex cascade of protein signaling that activates enzymes called caspases to initiate breakdown of the cancer cell. AT-406 is thought to mimic the activity of Smac (second mitochondria-derived ac
'/>"/>

SOURCE Ascenta Therapeutics
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2

Related medicine news :

1. Prime Therapeutics Receives TIPPS Certification
2. Adams Respiratory Therapeutics to Celebrate 10th Anniversary of its Incorporation on September 12
3. Transition Therapeutics Announces Fiscal 2007 Year End Financial Results
4. Lorus Therapeutics announces election of three new Directors and appoints a new Chairman
5. Deane F. Johnson Center for Neurotherapeutics to Launch First Mobile Medical Unit on October 4th
6. Russell Investment Group Advises Protalix Biotherapeutics of Index Adjustment
7. Adams Respiratory Therapeutics Announces FDA Approval of Grape-Flavored Delsym(R)
8. Prime Therapeutics Announces URAC Accreditation
9. Cell Therapeutics, Inc. (CTI) to Present at BIO Investor Forum
10. Horizon Therapeutics, Inc. Scheduled to Present at Upcoming BioPartnering Europe Meeting
11. Sontra Medical Corporation Changes Name to Echo Therapeutics, Inc.
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/1/2014)... MN (PRWEB) September 01, 2014 In honor of ... on Aug. 22, Animal Emergency & Referral Center of Minnesota (AERC) ... visits a priority for their cats. , Many people don’t take ... too much of a hassle,” but they wouldn’t decide not to ... signs of a cavity. The same goes for pets. Just like ...
(Date:9/1/2014)... Vegas, NV (PRWEB) September 01, 2014 ... entrepreneurs and online marketers that was developed to automate ... has caught the attention of Shane Michaels, prompting an ... established entrepreneur, the daily duty of managing all of ... business can be quite overwhelming,” reports Michaels. “That’s why ...
(Date:9/1/2014)... Pastor Thompson is an ordained minister and previously worked as ... licensed minister through the Church of the Nazarene and has ... Mexico, Colorado and North Dakota. He and his wife Heather ... also has two beautiful daughters, Brianna, 22 and Bethany, 17. ... Bible College, in Colorado Springs and is currently pursuing his ...
(Date:9/1/2014)... New York, US (PRWEB) September 01, 2014 ... a top-line view into Heartbeat Experts’ perspectives ... the Diabetes market. , Download the flash ... stakeholder strategies for any launching Diabetes product:, ... of differentiation within an increasingly crowded market ...
(Date:8/31/2014)... August 31, 2014 The FDA has ... Facts label. If adopted, the proposed changes would include ... of “added sugars” on the label, and a new ... keep “added sugars” off the label. NutriGold fully supports ... make healthier food choices. “After 20 years, it's time ...
Breaking Medicine News(10 mins):Health News:Animal Emergency & Referral Center of Minnesota Celebrates National Take Your Cat to the Vet Day 2Health News:Animal Emergency & Referral Center of Minnesota Celebrates National Take Your Cat to the Vet Day 3Health News:Ontraport: Review Exposes Automated Platform for Online Marketing Management 2Health News:Download HeartBeat Experts White Paper: Stakeholder Management for new Diabetes Products 2Health News:NutriGold Supports the FDA's Call for an Updated Nutrition Facts Label 2Health News:NutriGold Supports the FDA's Call for an Updated Nutrition Facts Label 3Health News:NutriGold Supports the FDA's Call for an Updated Nutrition Facts Label 4
... , , New line set to hit market in ... -- Jillian Michaels, New York Times bestselling author ... Loser announces her first ever line of weight-loss products in ... at the 2009 National Association of Chain Drug Stores Marketplace in ...
... ... psoriasis medications and the financial help available for those living with the disease ... (Vocus) June 29, 2009 -- ... those with psoriasis . The page is a psoriasis-specific source of help for those ...
... Florida,s First Certified Urgent Care ... Florida has become the first in the State to receive formal recognition as a Certified Urgent ... ... Medical Centers of Palm Beach County Florida has become the first in the State to receive ...
... , ... founder of the alternative health movement, is now a featured expert on searchvitaminsupplements.com, a new ... acids, enzymes, and more. , ... Potomac, MD (Vocus) June 29, 2009 -- Julian Whitaker, MD , a founder of ...
... ... the US Drug Watchdog, "we want to hear from any Zicam Nasal ... smell." The group says, "on June 16, 2009, the U.S. Food and ... remedies because they are associated with the loss of sense of smell ...
... 29 /PRNewswire-Asia/ -- Rising healthcare standards,together with the growing ... for medical tourism buoyant, according to experts speaking at ... Singapore.,Worldwide gross medical tourism revenue is projected to grow ... Asia as a major driver of this,growth. , ...
Cached Medicine News:Health News:Jillian Michaels, 'America's Toughest Trainer,' Announces New Line of Weight-Loss Supplements 2Health News:Jillian Michaels, 'America's Toughest Trainer,' Announces New Line of Weight-Loss Supplements 3Health News:New Source of Information on Psoriasis Medications 2Health News:MD Now Urgent Care Centers: First in Florida to Receive UCAOA Certification in Urgent Care 2Health News:MD Now Urgent Care Centers: First in Florida to Receive UCAOA Certification in Urgent Care 3Health News:Dr. Julian Whitaker Featured on Searchvitaminsupplements.com 2Health News:The US Drug Watchdog Expands its Zicam Investigation and Wants to Hear From All Users Who Lost Their Sense of Smell 2Health News:Healthcare Travel Exhibition & Congress Predicts Worldwide Healthcare Travel Revenue to Hit US$100 Billion by 2012 2Health News:Healthcare Travel Exhibition & Congress Predicts Worldwide Healthcare Travel Revenue to Hit US$100 Billion by 2012 3
(Date:8/29/2014)... , Aug. 29, 2014 Research and ... "Global Multiple Sclerosis Drugs Market 2014-2018" report to ... chronic, inflammatory medical condition that results in demyelination, axonal ... of an abnormal response by the immune system, which ... is a potentially debilitating disease in which the damage ...
(Date:8/29/2014)... 2014 Pixcelldata, the innovative Irish ... announced a major new deal with Dutch based eX-Path, ... expert, Dr. Marius Nap . The ... Congress of Pathology which is taking placing between August ... London where Pixcelldata will demonstrate its ...
(Date:8/28/2014)... Del. , Aug. 28, 2014  Rigrodsky & Long, P.A.: ... of Lannett Company, Inc. (NYSE: LCI )? , ... September 10, 2013 and July 16, 2014, inclusive? , ... , Do you want to discuss your rights? ... Special Assistant United States Attorney, Timothy J. MacFall , announces ...
Breaking Medicine Technology:Global Multiple Sclerosis Drugs Market 2014-2018: Key Vendors are Bayer, Biogen Idec, Merck Serono, Novartis and Teva Pharmaceutical 2Global Multiple Sclerosis Drugs Market 2014-2018: Key Vendors are Bayer, Biogen Idec, Merck Serono, Novartis and Teva Pharmaceutical 3Pixcelldata Announces New Deal with Dutch Tele-Pathology Specialists eX-Path Ahead of ECP 2014 2Rigrodsky & Long, P.A. Announces A Securities Fraud Class Action Lawsuit Has Been Filed Against Lannett Company, Inc. 2Rigrodsky & Long, P.A. Announces A Securities Fraud Class Action Lawsuit Has Been Filed Against Lannett Company, Inc. 3
... 2012  Ventana Medical Systems, Inc. (Ventana), a member ... has entered into a strategic collaboration agreement with ... companion diagnostic test intended to identify patients most ... conjugate (ADC). Ventana,s diagnostic immunohistochemistry platform aims to ...
... CareFusion today announced its Alaris System wireless ... to receive a new data encryption certification now required ... Affairs hospital networks. (Logo: http://photos.prnewswire.com/prnh/20100706/CAREFUSIONLOGO ) ... Standard (FIPS) 140-2, certifies that the Alaris System ...
Cached Medicine Technology:Ventana Medical Systems, Inc. to Collaborate with Bayer on Companion Diagnostic Test for New Biological Cancer Therapy 2Ventana Medical Systems, Inc. to Collaborate with Bayer on Companion Diagnostic Test for New Biological Cancer Therapy 3CareFusion Receives Federal Data Encryption Certification for Alaris® Infusion System 2
The GE e-Speed™scanner, the worlds fastest computed tomography (CT) imaging platform, delivers a new advanced tool for physicians to see and diagnose heart disease....
...
Angled 45 Degrees to Right, 9.5mm blade, gently curved .5x .25mm blunt tips; Lower blade is 0.5mm longer; 14mm from mid screw to tip; (Available in left and right;) overall length 120mm; Stainless ...
16mm Slightly Curved sharp Tips; overall length 120mm; Stainless Steel...
Medicine Products: