Navigation Links
Artificial liver for drug tests
Date:6/25/2009

This release is available in German.

If you have hay fever, headaches or a cold, it's only a short way to the nearest chemist. The drugs, on the other hand, can take eight to ten years to develop. Until now animal experiments have been an essential step, yet they continue to raise ethical issues. "Our artificial organ systems are aimed at offering an alternative to animal experiments," says Professor Heike Mertsching of the Fraunhofer Institute for Interfacial Engineering and Biotechnology IGB in Stuttgart. "Particularly as humans and animals have different metabolisms. 30 per cent of all side effects come to light in clinical trials." The test system, which Professor Mertsching has developed jointly with Dr. Johanna Schanz, should in future give pharmaceutical companies greater security and shorten the path to new drugs. Both researchers received the "Human-centered Technology" prize for their work.

"The special feature, in our liver model for example, is a functioning system of blood vessels," says Dr. Schanz. "This creates a natural environment for cells." Traditional models do not have this, and the cells become inactive. "We don't build artificial blood vessels for this, but use existing ones from a piece of pig's intestine." All of the pig cells are removed, but the blood vessels are preserved. Human cells are then seeded onto this structure hepatocytes, which, as in the body, are responsible for transforming and breaking down drugs, and endothelial cells, which act as a barrier between blood and tissue cells. In order to simulate blood and circulation, the researchers put the model into a computer-controlled bioreactor with flexible tube pump, developed by the IGB. This enables the nutrient solution to be fed in and carried away in the same way as in veins and arteries in humans. "The cells were active for up to three weeks," says Dr. Schanz. "This time was sufficient to analyze and evaluate the functions. A longer period of activity is possible, however." The researchers established that the cells work in a similar way to those in the body. They detoxify, break down drugs and build up proteins. These are important pre-conditions for drug tests or transplants, as the effect of a substance can change when transformed or broken down many drugs are only metabolized into their therapeutic active form in the liver, while others can develop poisonous substances. The researchers have demonstrated the basic possibilities for use of the tissue models liver, skin, intestine and windpipe. At the moment, the test system is being examined. Within two years it could provide a safer alternative to animal experiments.


'/>"/>

Contact: Heike Mertsching
heike.mertsching@igb.fraunhofer.de
49-711-970-4117
Fraunhofer-Gesellschaft
Source:Eurekalert  

Related medicine news :

1. Artificial Ankle Takes Giant Step Forward
2. Dr. Dean Dornic Certified to Perform Artificial Cornea Transplant
3. Automated Artificial Pancreas Controls Blood Glucose Levels in Diabetes Patients for First Time
4. Artificial liver may extend lives
5. New Video Series Spotlights Role of Biomedical Engineers in Caring for Total Artificial Heart Patients
6. INTERMACS: Total Artificial Heart Bridge-to-Transplant Rate 2x Higher at 6 Months Than BiVADS and LVADs
7. Total Artificial Heart Patient 3rd in the World to Receive Dual Transplants
8. SynCardia Introduces New 12-lb Freedom Discharge Driver Designed to Provide Quality 'Lifestyle' for Total Artificial Heart Patients
9. Artificial pump effectively backs up failing hearts
10. Researchers Successfully Create Computer-Simulated Model for Evaluating Artificial Pancreas
11. Artificial disc replacement as good or better than spinal fusion surgery
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Artificial liver for drug tests
(Date:3/24/2017)... ... March 24, 2017 , ... Empower Brokerage, located ... training and leads programs. , In February, 2017, Empower Brokerage introduced their new ... Partners is designed to teach how to maximize their sales efforts, as well ...
(Date:3/24/2017)... ... March 24, 2017 , ... “Finding Christ Through ... a devotional journal chronicling the writer’s path toward true communion with God. “Finding ... God #TruthwithGrace” is the creation of published author Lea Michelle Johnson, a follower ...
(Date:3/24/2017)... , ... March 24, 2017 , ... “Vintage and Harvest ... retired minister and college Bible teacher residing in North Carolina with his wife, Anna ... have blessed them with six grandchildren. David is also the author of “Shadow and ...
(Date:3/24/2017)... ... ... “The Adventures of Joey, The Dog Who Barks at Puddles”: a boisterous ... the fullest, as God intended. “The Adventures of Joey, The Dog Who Barks at ... her passion for writing, especially about truth and human behavior. , Published by Christian ...
(Date:3/23/2017)... ... 2017 , ... A recent report from the National Council on Teacher Quality ... report suggests, based on a review of GPA and SAT/ACT requirements at 221 institutions ... U.S. It argues that this higher bar should be set by states, by the ...
Breaking Medicine News(10 mins):
(Date:3/23/2017)... , March 23, 2017 Mosaic Life Care, based in ... patient registration process across its network of 58 clinics, located in 22 cities, and ... new and innovative ways to improve the delivery of health care to its patients, ... Reading ... Mosaic Life Care St. Joseph Medical Center ...
(Date:3/23/2017)... 2017  Transportation Insight, a multi-modal lead logistics solutions ... management firm with expertise serving clients in the food ... Zaffarano was named a 2017 Food Logistics ... the only publication exclusively dedicated to covering the movement ... "Rick has brought to Transportation Insight a wealth ...
(Date:3/23/2017)... As a result of diagnostic technology ... of allergic diseases, cutting edge developments in targeted ... ways in which pharmaceutical and biotech companies are ... be both a high quality meeting and a ... immunologists, research scholars and doctors. The event will ...
Breaking Medicine Technology: