Navigation Links
Artificial Pancreas Worked Overnight on Kids With Type 1 Diabetes
Date:2/27/2013

By Serena Gordon
HealthDay Reporter

WEDNESDAY, Feb. 27 (HealthDay News) -- The artificial pancreas -- a treatment that's been called the closest thing to a possible cure for type 1 diabetes -- may be another step closer to becoming a reality.

Israeli researchers just released the findings from an overnight trial of their artificial pancreas system at three different camps for youngsters with type 1 diabetes. The artificial pancreas system was able to maintain better blood sugar levels, and helped prevent dangerous overnight drops in blood sugar levels, compared to an insulin pump and a continuous glucose monitor, according to the study.

"There is hope for better control without the fear of [low blood sugar levels], and therefore improvement in quality of life is coming soon," said study author Dr. Moshe Phillip.

Philip is director of the Institute for Endocrinology and Diabetes at the National Center for Childhood Diabetes at the Schneider Children's Medical Center of Israel, in Tel Aviv. The findings appear in the Feb. 28 issue of the New England Journal of Medicine.

Type 1 diabetes is an autoimmune disease in which the body's immune system turns against healthy cells. In type 1 diabetes, the immune system attacks beta cells in the pancreas, effectively destroying the body's ability to produce the hormone insulin. Insulin helps metabolize carbohydrates from food and fuels the body's cells.

Insulin can't be replaced with a pill. It must be injected with a shot or delivered by a pump that uses a tiny catheter inserted under the skin. This catheter must be changed every few days. The problem with both techniques is that people have to estimate how much insulin they'll need based on the foods they eat and how much activity they'll be doing.

Too much insulin can result in low blood sugar levels (hypoglycemia), which makes a person with diabetes feel awful, and if left untreated, can cause a person to pass out. Low blood sugar levels can even lead to death. Too little insulin leads to high blood sugar levels (hyperglycemia), which over time can cause serious complications, such as heart disease and kidney and eye problems.

An artificial pancreas could potentially solve those problems by taking over the decision-making process and applying sophisticated computer algorithms to decide how much insulin is needed at any given moment.

But developing such a device isn't easy. It has to be able to continuously detect patients' blood sugar levels and know whether the levels are trending up or down. There also has to be a piece of the device that holds and delivers insulin. Right now, most artificial pancreas devices, including the one tested in this study, use already-available insulin pumps and continuous glucose monitors. Such monitors measure blood sugar levels every few minutes with a sensor that's inserted under the skin, and send the results to a transmitter.

An artificial pancreas also needs a place to house its computer program or algorithm. Right now, that's generally housed in a laptop that sits on the bedside overnight, as it was in the current study. The hope is that the algorithm could exist within one of the other devices, or maybe even as an application on a cell phone.

In the new study, 56 children from three different diabetes camps in Israel, Slovenia and Germany were randomly assigned to an overnight session on the artificial pancreas, or with standard treatment using an insulin pump and continuous glucose monitor. The following night, they switched.

All of the children had type 1 diabetes, and were between the ages of 10 and 18.

Diabetes camps offer a great place to test the artificial pancreas, because the children are often far more active than usual. All that extra activity leaves them prone to low blood sugar levels throughout the night. Also, staff members are already assigned to check blood sugar levels at certain times in the night.

The artificial pancreas system tested in this study shuts off insulin delivery when it senses that blood sugar levels are going too low. It can also deliver additional insulin when blood sugar levels are rising.

A low blood sugar level is below 70 milligrams per deciliter (mg/dL). On nights that children were on standard treatment, 36 episodes of low blood sugar occurred. On nights that youngsters were on the artificial pancreas, only 12 low blood sugar episodes occurred. Phillip said adjustments could be made to the artificial pancreas to reduce the number of episodes on the artificial pancreas even further.

One diabetes expert talked about the device.

"Overnight control is the most difficult and worrisome part of diabetes management," explained Aaron Kowalski, vice president for treatment therapies at JDRF (formerly the Juvenile Diabetes Research Foundation), based in New York City.

"It's amazing how effective the artificial pancreas is at reducing low blood sugar levels without having to wake up a child and make them eat something, which disturbs their sleep, adds calories to their day and leaves sugar on their teeth overnight," Kowalski said.

The artificial pancreas also maintained blood sugar levels at an average of about 126 mg/dL compared to 140 mg/dL for the standard treatment. The goal of insulin treatment is to maintain blood sugar levels as low as possible without dropping below 70 mg/dL, so the artificial pancreas offered more effective treatment.

Phillip said his group is now testing the artificial pancreas in people's homes.

JDRF's Kowalski said outpatient trials of different artificial pancreas systems are going on in the United States as well.

More information

For more about the artificial pancreas system, visit the U.S. Food and Drug Administration.

SOURCES: Moshe Phillip, M.D., director, Institute for Endocrinology and Diabetes, National Center for Childhood Diabetes, Schneider Children's Medical Center of Israel, and vice dean, research and development, Sackler Faculty of Medicine, Tel Aviv University, Isreal; Aaron Kowalski, Ph.D., vice president, treatment therapies, JDRF, New York City; Feb. 28, 2013, New England Journal of Medicine


'/>"/>
Copyright©2012 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Swine cells could power artificial liver
2. Hear This: 3-D Printing Creates Lifelike Artificial Ears
3. Artificial Organs (Medical Bionic Implants) Market is expected to grow at a CAGR of 7.1% & to reach $17.82 billion by 2017 - New Report by MarketsandMarkets
4. Artificial pancreas: The way of the future for treating type 1 diabetes
5. FDA: Dont Use Pradaxa Blood Thinner in Patients With Artificial Heart Valves
6. A leap forward in the quest to develop an artificial pancreas
7. Artificial butter flavoring ingredient linked to key Alzheimers disease process
8. Farmers tough on artificial limbs
9. Could Compound in Artificial Sweeteners Worsen Crohns Disease?
10. Pancreas stem cell discovery may lead to new diabetes treatments
11. Mayo Clinic: Diabetes can be controlled in patients after pancreas removal
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Artificial Pancreas Worked Overnight on Kids With Type 1 Diabetes
(Date:10/13/2017)... ... October 13, 2017 , ... Global Healthcare Management’s 4th Annual Kids Fun Run ... This free event, sponsored by Global Healthcare Management’s CEO, Jon Letko, is aimed ... geared towards children of all ages; it is a non-competitive, non-timed event, which is ...
(Date:10/13/2017)... ... October 13, 2017 , ... “The Journey: From the Mountains to the Mission ... lost souls in the Philippines. “The Journey: From the Mountains to the Mission Field” ... the Bible. She has taught all ages and currently teaches a class of ladies ...
(Date:10/12/2017)... , ... October 12, 2017 , ... Planet Fitness, one ... U.S., announced today its plans to open a flagship location in Covington, LA at ... former Rooms To Go store next to Office Depot in the Holiday Square shopping ...
(Date:10/12/2017)... ... October 12, 2017 , ... Asante, a ... health care, have expanded their existing home health joint venture through an agreement, ... been operating a joint venture home health company with Asante, delivering clinically integrated ...
(Date:10/12/2017)... ... October 12, 2017 , ... Leading pediatric oncology experts at ... for the 49th Congress of the International Society of Paediatric Oncology (SIOP) ... Center for Cancer and Blood Disorders at Children’s National, and Stephen P. ...
Breaking Medicine News(10 mins):
(Date:10/2/2017)... 2017  AllianceRx Walgreens Prime, the combined central specialty ... pharmacy benefit manager Prime Therapeutics LLC (Prime), today officially ... the unveiling of new signage at its headquarters in ... at a few other company-owned facilities across the country. ... some of whom will begin to see the AllianceRx ...
(Date:9/27/2017)... Sept. 27, 2017  Commended for their devotion to personalized ... Ranked as number one in the South Florida Business Journal,s ... Inc. 5000 yearly list, the national specialty pharmacy has found ... Bardisa will soon be honored by SFBJ as the ... Set to receive his award in October, Bardisa ...
(Date:9/22/2017)... 22, 2017  As the latest Obamacare repeal effort ... Cassidy (R-LA) and Lindsey Graham (R-SC) ... medical device industry is in an odd place.  The ... 2.3% excise tax on medical device sales passed along ... covered patients, increased visits and hospital customers with the ...
Breaking Medicine Technology: