Navigation Links
Arteries under pressure early on

High fat diets cause damage to blood vessels earlier than previously thought, and these structural and mechanical changes may be the first step in the development of high blood pressure. These findings in mice, by Marie Billaud and colleagues from the University of Virginia School of Medicine in the US, are published online in Springer's Journal of Cardiovascular Translational Research.

With age, increasing weight and metabolic disease, the internal walls of our large arteries progressively thicken and become less elastic, which can lead to furring up of the arteries (atherosclerosis) and increased resistance and high blood pressure in severe cases. At present, researchers and physicians tend to measure arterial compliance (a measure of arterial stiffness) in large arteries in relatively advanced stages of metabolic diseases.

However, this may not provide the full picture of when a disease starts and how it develops. In addition, previous work has suggested that structural alterations in the walls of small arteries are the most potent predictor of cardiovascular diseases, suggesting that early identification of these changes is important.

Billaud and team compared the arterial compliance of two different sized arteries: carotid (large) and thoracodorsal (smaller) in two groups of mice: one fed a high-fat diet for six weeks; the other a control group on a traditional diet.

They found that the structural and mechanical properties of small arteries were rapidly altered, even after only six weeks of high fat feeding. Specifically, the compliance of the smaller arteries was dramatically reduced in the mice on the high-fat diet, whereas there was no change in stiffness in the larger arteries. The researchers also found a build-up of collagen in the walls of the smaller arteries.

The authors conclude: "These results suggest that, at an early stage of obesity, the structural properties of small and large arteries are altered whereas arterial stiffness is only observed in small vessels. This implies that small vessels are targeted earlier compared to large arteries, and this could therefore play a role in the development of hypertension associated with a long-term caloric-enriched diet."


Contact: Joan Robinson

Related medicine news :

1. Cooling inflammation for healthier arteries
2. American Stroke Association Late-Breaking Science Report: Surgery, Stenting to Open Blocked Neck Arteries Similar in Safety, Efficacy, But Show Differences in Stroke, Heart Attack and Death Rates at Certain Ages
3. Stents as good as surgery for clogged carotid arteries
4. Popular Diet Plans Can Unclog Arteries
5. Secondhand Smoke Starts Damaging Arteries in Childhood
6. New method to grow arteries could lead to biological bypass for heart disease
7. Arteries Age Twice as Fast in Smokers
8. Link established between erectile dysfunction and calcified coronary arteries
9. Calcium, Vitamin D Supplements OK for Arteries
10. Procedure Rejuvenates Aging Arteries in Pigs
11. Award-winning study: Hardening of the arteries doubles the risk of mortality
Post Your Comments:
(Date:6/26/2016)... ... June 26, 2016 , ... Pixel Film Studios Released ProSlice ... "Film editors can give their videos a whole new perspective by using the ... of Pixel Film Studios. , ProSlice Levels contains over 30 Different presets to ...
(Date:6/25/2016)... ... June 25, 2016 , ... ... and applications at AcademyHealth’s Annual Research Meeting June 26-28, 2016, at the Hynes ... important health care topics including advance care planning, healthcare costs and patient and ...
(Date:6/25/2016)... ... June 25, 2016 , ... First Choice Emergency ... named Dr. Sesan Ogunleye, as the Medical Director of its new Mesquite-Samuell Farm facility. ... Director of our new Mesquite location,” said Dr. James M. Muzzarelli, Executive Medical Director ...
(Date:6/25/2016)... ... June 25, 2016 , ... Conventional wisdom preaches the benefits of moderation, whether ... latter, setting the bar too high can result in disappointment, perhaps even self-loathing. However, ... their goal. , Research from reveals that behind the tendency ...
(Date:6/24/2016)... PASADENA, CA (PRWEB) , ... June 24, 2016 , ... Marcy was in a crisis. ... he would lash out at his family verbally and physically. , “When something upset him, ... table, he would use it. He would throw rocks at my other children and say ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... , June 24, 2016  Consumers have ... and regulators/payers have placed more emphasis on patient ... patient support programs in the pharmaceutical industry have ... medications. Consequently, pharmaceutical companies are focusing on becoming ... are providing products and services that improve health. ...
(Date:6/24/2016)... CAMBRIDGE, Mass. , June 24, 2016 /PRNewswire/ ... the Spaulding Rehabilitation Network,s Dean Center for ... of Physical Medicine and Rehabilitation, MIT Hacking Medicine, ... Center for Innovation, today announced the five finalists ... Hackathon for Lyme disease.  More than 100 scientists, ...
(Date:6/24/2016)... -- The Academy of Managed Care Pharmacy (AMCP) today ... allow biopharmaceutical companies to more easily share health care ... coverage decisions, a move that addresses the growing need ... The recommendations address restrictions in the sharing of product ... a prohibition that hinders decision makers from accessing HCEI ...
Breaking Medicine Technology: