Navigation Links
Arteries under pressure early on
Date:4/3/2012

High fat diets cause damage to blood vessels earlier than previously thought, and these structural and mechanical changes may be the first step in the development of high blood pressure. These findings in mice, by Marie Billaud and colleagues from the University of Virginia School of Medicine in the US, are published online in Springer's Journal of Cardiovascular Translational Research.

With age, increasing weight and metabolic disease, the internal walls of our large arteries progressively thicken and become less elastic, which can lead to furring up of the arteries (atherosclerosis) and increased resistance and high blood pressure in severe cases. At present, researchers and physicians tend to measure arterial compliance (a measure of arterial stiffness) in large arteries in relatively advanced stages of metabolic diseases.

However, this may not provide the full picture of when a disease starts and how it develops. In addition, previous work has suggested that structural alterations in the walls of small arteries are the most potent predictor of cardiovascular diseases, suggesting that early identification of these changes is important.

Billaud and team compared the arterial compliance of two different sized arteries: carotid (large) and thoracodorsal (smaller) in two groups of mice: one fed a high-fat diet for six weeks; the other a control group on a traditional diet.

They found that the structural and mechanical properties of small arteries were rapidly altered, even after only six weeks of high fat feeding. Specifically, the compliance of the smaller arteries was dramatically reduced in the mice on the high-fat diet, whereas there was no change in stiffness in the larger arteries. The researchers also found a build-up of collagen in the walls of the smaller arteries.

The authors conclude: "These results suggest that, at an early stage of obesity, the structural properties of small and large arteries are altered whereas arterial stiffness is only observed in small vessels. This implies that small vessels are targeted earlier compared to large arteries, and this could therefore play a role in the development of hypertension associated with a long-term caloric-enriched diet."


'/>"/>

Contact: Joan Robinson
joan.robinson@springer.com
49-622-148-78130
Springer
Source:Eurekalert

Related medicine news :

1. Cooling inflammation for healthier arteries
2. American Stroke Association Late-Breaking Science Report: Surgery, Stenting to Open Blocked Neck Arteries Similar in Safety, Efficacy, But Show Differences in Stroke, Heart Attack and Death Rates at Certain Ages
3. Stents as good as surgery for clogged carotid arteries
4. Popular Diet Plans Can Unclog Arteries
5. Secondhand Smoke Starts Damaging Arteries in Childhood
6. New method to grow arteries could lead to biological bypass for heart disease
7. Arteries Age Twice as Fast in Smokers
8. Link established between erectile dysfunction and calcified coronary arteries
9. Calcium, Vitamin D Supplements OK for Arteries
10. Procedure Rejuvenates Aging Arteries in Pigs
11. Award-winning study: Hardening of the arteries doubles the risk of mortality
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/23/2017)... ... March 23, 2017 , ... Benefits ... an innovative mobile app and centralized benefits dashboard solving one of the top ... from multiple locations. For the first time, employees can access up-to-date information and ...
(Date:3/23/2017)... ... March 23, 2017 , ... Michael Lanteri ... the greater Fort Collins area, has unveiled a collaboration with nonprofit Big Bones ... Donations to this worthy cause may now be made at http://bigbonescaninerescue.com/ . ...
(Date:3/23/2017)... Fla. (PRWEB) , ... March 23, 2017 , ... ... transforming healthcare for seniors, today announced rapid completion of the strategic executive team ... announce several notable additions to the ChenMed executive team,” says Christopher Chen, MD, ...
(Date:3/23/2017)... ... March 23, 2017 , ... Inflow IQ & Inflownomics ... serious so build on a solid foundation. As experts in dangerous situations the ... that is coming soon. Inflownomics deliver ripe, fresh, clean & refreshing knowledge systems that ...
(Date:3/23/2017)... , ... March 23, 2017 , ... ... awarded Task Force Dagger Foundation the US Special Operations Command’s Patriot Award. The ... presentation, General Thomas thanked Task Force Dagger Foundation for its significant and enduring ...
Breaking Medicine News(10 mins):
(Date:3/23/2017)...  Digital Pharmacist Inc. ( ... digital health company, announced today that it has ... to manage their prescriptions. Over three hundred pharmacy ... Pharmacy, USave Pharmacy and Owen,s Healthcare use the ... its product development schedule, the company now powers ...
(Date:3/23/2017)... Research and Markets has announced the addition ... their offering. ... The global capillary electrophoresis market to grow at a CAGR of ... Capillary Electrophoresis Market 2017-2021, has been prepared based on an in-depth ... market landscape and its growth prospects over the coming years. The ...
(Date:3/23/2017)... Newborns are highly vulnerable to infections ... their young immune systems typically mount weak antibody ... achieving strong vaccine responses in newborn animals, including ... trials — by adding compounds known as adjuvants ... papers, they also describe improved adjuvant formulations that ...
Breaking Medicine Technology: