Navigation Links
Arteries under pressure early on
Date:4/3/2012

High fat diets cause damage to blood vessels earlier than previously thought, and these structural and mechanical changes may be the first step in the development of high blood pressure. These findings in mice, by Marie Billaud and colleagues from the University of Virginia School of Medicine in the US, are published online in Springer's Journal of Cardiovascular Translational Research.

With age, increasing weight and metabolic disease, the internal walls of our large arteries progressively thicken and become less elastic, which can lead to furring up of the arteries (atherosclerosis) and increased resistance and high blood pressure in severe cases. At present, researchers and physicians tend to measure arterial compliance (a measure of arterial stiffness) in large arteries in relatively advanced stages of metabolic diseases.

However, this may not provide the full picture of when a disease starts and how it develops. In addition, previous work has suggested that structural alterations in the walls of small arteries are the most potent predictor of cardiovascular diseases, suggesting that early identification of these changes is important.

Billaud and team compared the arterial compliance of two different sized arteries: carotid (large) and thoracodorsal (smaller) in two groups of mice: one fed a high-fat diet for six weeks; the other a control group on a traditional diet.

They found that the structural and mechanical properties of small arteries were rapidly altered, even after only six weeks of high fat feeding. Specifically, the compliance of the smaller arteries was dramatically reduced in the mice on the high-fat diet, whereas there was no change in stiffness in the larger arteries. The researchers also found a build-up of collagen in the walls of the smaller arteries.

The authors conclude: "These results suggest that, at an early stage of obesity, the structural properties of small and large arteries are altered whereas arterial stiffness is only observed in small vessels. This implies that small vessels are targeted earlier compared to large arteries, and this could therefore play a role in the development of hypertension associated with a long-term caloric-enriched diet."


'/>"/>

Contact: Joan Robinson
joan.robinson@springer.com
49-622-148-78130
Springer
Source:Eurekalert

Related medicine news :

1. Cooling inflammation for healthier arteries
2. American Stroke Association Late-Breaking Science Report: Surgery, Stenting to Open Blocked Neck Arteries Similar in Safety, Efficacy, But Show Differences in Stroke, Heart Attack and Death Rates at Certain Ages
3. Stents as good as surgery for clogged carotid arteries
4. Popular Diet Plans Can Unclog Arteries
5. Secondhand Smoke Starts Damaging Arteries in Childhood
6. New method to grow arteries could lead to biological bypass for heart disease
7. Arteries Age Twice as Fast in Smokers
8. Link established between erectile dysfunction and calcified coronary arteries
9. Calcium, Vitamin D Supplements OK for Arteries
10. Procedure Rejuvenates Aging Arteries in Pigs
11. Award-winning study: Hardening of the arteries doubles the risk of mortality
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2016)... Carolina (PRWEB) , ... June 26, 2016 , ... ... of a new product that was developed to enhance the health of felines. The ... centuries. , The two main herbs in the PawPaws Cat Kidney Support ...
(Date:6/25/2016)... ... June 25, 2016 , ... Experts from the American ... Annual Research Meeting June 26-28, 2016, at the Hynes Convention Center in Boston. ... including advance care planning, healthcare costs and patient and family engagement. , AIR ...
(Date:6/25/2016)... ... June 25, 2016 , ... "With 30 hand-drawn hand ... project," said Christina Austin - CEO of Pixel Film Studios. , ProHand Cartoon’s ... within Final Cut Pro X . Simply select a ProHand generator and drag ...
(Date:6/25/2016)... ... June 25, 2016 , ... Dr. ... from injury. Recently, he has implemented orthobiologic procedures as a method for treating ... one of the first doctors to perform the treatment. Orthobiologics are substances that ...
(Date:6/24/2016)... CA (PRWEB) , ... June 24, 2016 , ... A ... procedures that most people are unfamiliar with. The article goes on to state that ... but also many of these less common operations such as calf and cheek reduction. ...
Breaking Medicine News(10 mins):
(Date:6/26/2016)... OTTAWA, Ontario , June 27, 2016  VMS ... the Company,s Board will take whatever measures required to ... the Company,s stock which is currently listed on the ... S Wexler, Company Chairman and CEO, "We are seeing ... be difficult to understand, not only by the Company, ...
(Date:6/24/2016)... , June 24, 2016   Bay Area ... Network,s Dean Center for Tick Borne Illness ... and Rehabilitation, MIT Hacking Medicine, University of California, ... today announced the five finalists of Lyme ... disease.  More than 100 scientists, clinicians, researchers, entrepreneurs, ...
(Date:6/24/2016)... SAN CLEMENTE, Calif. , June 24, 2016 /PRNewswire/ ... pulmonary function testing company, is now able to perform sophisticated lung ... ndd Medical Technologies , Inc. Patients are ... labs.  Thanks to ndd,s EasyOne PRO ® , ARL patients like ... any needed testing done in the comfort of her own home. ...
Breaking Medicine Technology: