Navigation Links
Arsenic shows promise as cancer treatment, Stanford study finds
Date:7/12/2010

STANFORD, Calif. Miss Marple notwithstanding, arsenic might not be many people's favorite chemical. But the notorious poison does have some medical applications. Specifically, a form called arsenic trioxide has been used as a therapy for a particular type of leukemia for more than 10 years. Now researchers at the Stanford University School of Medicine have shown that it may be useful in treating a variety of other cancers.

Combining arsenic with other therapies may give doctors a two-pronged approach to beating back forms of the disease caused by a malfunction in a critical cellular signaling cascade called the Hedgehog pathway. The U.S. Food and Drug Administration has already approved arsenic trioxide for use in humans, which could pave the way for clinical trials of this approach.

"Many pharmaceutical companies are developing anticancer drugs to inhibit the Hedgehog pathway," said Philip Beachy, PhD, professor of developmental biology and the Ernest and Amelia Gallo Professor in the School of Medicine. In addition, Beachy recently identified an antifungal drug commonly used in humans, itraconazole, as a Hedgehog pathway inhibitor. "However, these compounds target a component of the pathway that can be mutated with patients then becoming resistant to the therapy. Arsenic blocks a different step of the cascade."

Beachy is the senior author of the new findings about arsenic, which will be published online in the Proceedings of the National Academy of Sciences July 12. Jynho Kim, DVM, PhD, a postdoctoral scholar in Beachy's lab, is the first author of the study.

The mechanism of action described by the researchers in the current paper differs from what happens during arsenic poisoning, which occurs when higher levels of the compound choke off a cell's energy production system.

Beachy and his colleagues studied the effect of arsenic trioxide in cultured human and mouse cells and in laboratory mice with a brain tumor known as medul
'/>"/>

Contact: Ruthann Richter
richter1@stanford.edu
650-725-8047
Stanford University Medical Center
Source:Eurekalert

0

GOOD

Page: 1 2 3

Related medicine news :

1. New study links 1 in 5 deaths in Bangladesh to arsenic in the drinking water
2. Deadly effect of arsenic in drinking water measured in massive study
3. Scientists offer solutions to arsenic groundwater poisoning in southern Asia
4. Arsenic exposure activates an oncogenic signaling pathway; leads to increased cancer risk
5. Pediatric clinical studies appear prone to bias, Hopkins review shows
6. Drug study shows improvement in major orthopedic surgery care
7. Doctor-Patient E-Mails Are a Healthy Addition, Research Shows
8. Ticking biological clock increases womens libido, new research shows
9. Study shows race, not experience, impacts hiring in sports world
10. Study Shows People Lose Twice the Weight on New Lifestyle Diet Compared to Other Diet Programs
11. Study shows short-term kidney failure in heart patients may not be as detrimental
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/19/2013)... Actos lawsuit claims continue ... in U.S. District Court, Western District of Louisiana. ... the Court has modified the litigation’s Bellwether Nomination process, ... than four. The next Status Conference in the federal ... re: Actos Product Liability Litigation, MDL No. 2299) , ...
(Date:5/19/2013)... May 19, 2013 The muscles in ... their functionality and one of the biggest and most ... nervous system. The peripheral system comprises of peripheral nerves ... cord. These nerves ensure that the limbs and hands, ... when these nerves get damaged due to trauma or ...
(Date:5/19/2013)... 19, 2013 Today, Zane Benefits, ... business health insurance . Zane Benefits, which provides ... health benefits, is the leader in health care ... reimbursement arrangements . , According to Zane Benefits’ ... intrinsically know the value of small business health ...
(Date:5/19/2013)... May 19, 2013 Grinding your teeth ... losing sleep, or annoying your spouse. At the same ... CNY Central (“Snoring and Teeth Grinding Could Be a ... teeth grinding can be hard to prevent. Apparently, Obstructive ... and one of its symptoms is a habit of ...
(Date:5/19/2013)... (PRWEB) May 19, 2013 According ... Market Analysis and Forecast (2013 – 2018): By ... Defense, Industrial)); Technology (CCD, CMOS, Contact IS, Infrared, ... of image sensor market was $8.00 billion in ... in 2018, at an estimated CAGR of 3.84% ...
Breaking Medicine News(10 mins):Health News:Actos Lawyers at Bernstein Liebhard LLP Note Issuance of New Case Management Order in Federal Actos Bladder Cancer Litigation 2Health News:Actos Lawyers at Bernstein Liebhard LLP Note Issuance of New Case Management Order in Federal Actos Bladder Cancer Litigation 3Health News:Ultimate Neuropathy Support System Launched by Neuracel - Reaching New Heights in Herbal Medication for Peripheral Neuropathy 2Health News:Zane Benefits Publishes New Information on Small Business Health Insurance 2Health News:Zane Benefits Publishes New Information on Small Business Health Insurance 3Health News:Dr. Kanani, Woodland Hills Dentist: Dangers of Tooth Damage and Obstructive Sleep Disorder 2Health News:Dr. Kanani, Woodland Hills Dentist: Dangers of Tooth Damage and Obstructive Sleep Disorder 3Health News:Image Sensors Market to Reach $10.75 Billion by 2018 at a CAGR of 3.84% - New Report by MarketandMarkets 2Health News:Image Sensors Market to Reach $10.75 Billion by 2018 at a CAGR of 3.84% - New Report by MarketandMarkets 3
... a special supplement, "Evaluation of the American Academy of ... Annals of Family Medicine reports on the results ... medical home concept in primary care practices. ... in 36 diverse U.S. primary care practices, an independent ...
... ... radio listeners on The Penn Project Show that, “The obesity crisis and related problems, such ... America needs to reverse that pro-inflammatory trend with anti-inflammatory diets, such as the Zone Diet." ... New Haven, CT (Vocus) ...
... ... Hispanic families found that untreated tooth decay in mothers almost doubled the odds of tooth ... and their children, the authors say. , ... (Vocus) June 15, 2010 -- A UCSF study examining the oral health of ...
... in wiring previously thought to be fixed , TUESDAY, ... fixed in early life, and circuits in the adult ... study involving mice. , U.S. researchers found that neurons ... alter their relationships with one another after single whiskers ...
... study led by UNC researchers that looks at newly diagnosed lung ... the first to give reasons why patients don,t go to lung ... most profound finding was the fact that African Americans with two ... four out of 100, whereas white patients in the same situation ...
... for those with MRSA in respiratory tract, study shows ... patients with methicillin-resistant staphylococcus aureus (MRSA) in their respiratory ... drug-resistant bacteria, researchers have found. , The new study, ... Journal of the American Medical Association , included 19,833 ...
Cached Medicine News:Health News:Results of first national demonstration project to implement patient-centered medical home released 2Health News:Results of first national demonstration project to implement patient-centered medical home released 3Health News:Results of first national demonstration project to implement patient-centered medical home released 4Health News:Results of first national demonstration project to implement patient-centered medical home released 5Health News:Results of first national demonstration project to implement patient-centered medical home released 6Health News:Results of first national demonstration project to implement patient-centered medical home released 7Health News:Clear Channel's “Penn Project” Features Dr. Barry Sears, Zone Diet Creator, About Obesity in America 2Health News:If Mother Has Tooth Decay, Odds Increase That Child Does Too 2Health News:If Mother Has Tooth Decay, Odds Increase That Child Does Too 3Health News:UNC study helps explain why black patients with lung cancer have surgery less often than whites 2Health News:UNC study helps explain why black patients with lung cancer have surgery less often than whites 3Health News:Drug-Resistant Staph Threatens Cystic Fibrosis Patients 2
(Date:5/19/2013)... , May 19, 2013  The non-surgical ... low temperature radiofrequency (RF) energy is effective in ... or reduces the need for medication 10 years ... presented today at the Digestive Disease Week (DDW) ... Florida . "The sustained ...
(Date:5/18/2013)... 2013 Although colonoscopy exams prevent many colon ... sensitive method for detecting colorectal cancers 2 , the ... 3 . EndoChoice ® Inc. today unveiled research ... the accuracy of this procedure and greatly reduces the ... discussing these clinical trial results and featuring the Fuse ...
(Date:5/18/2013)... May 18, 2013 The Open Paradigm ... Occupy Psychiatry , and leading organizations ... announces a social media campaign showcasing video testimonials ... model, which focuses on pathology and illness rather ... the American Psychiatric Association,s (APA) rollout of its ...
Breaking Medicine Technology:Stretta Procedure for GERD: Successful 10 Year Follow-Up Data Presented at Digestive Disease Week--Sustained Improvement, Long-Term Efficacy 2Stretta Procedure for GERD: Successful 10 Year Follow-Up Data Presented at Digestive Disease Week--Sustained Improvement, Long-Term Efficacy 3New Study Shows Full Spectrum Endoscopy Procedure Reduces The 'Miss Rate' of Adenomas During Colonoscopy 2New Study Shows Full Spectrum Endoscopy Procedure Reduces The 'Miss Rate' of Adenomas During Colonoscopy 3New Social Media Campaign Features Stories Of Individuals Who Rejected Psychiatric Diagnoses 2New Social Media Campaign Features Stories Of Individuals Who Rejected Psychiatric Diagnoses 3
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
Medicine Products: