Navigation Links
Arsenic exposure activates an oncogenic signaling pathway; leads to increased cancer risk
Date:2/23/2010

signaling by decreasing the stability of the repressor form of GLI3, which is one of the transcription factors that regulate Hedgehog activity. Also, Karagas and colleagues found high levels of arsenic exposure associated with high levels of Hedgehog activity.

"Constitutive Hedgehog signaling has been implicated in a wide spectrum of solid tumors," said Anthony Capobianco, Ph.D., editorial board member of Cancer Research. "This group observed increased Hedgehog activity in a large set of human bladder tumors. Interestingly, they also detected a strong correlation between high-level Hedgehog activity and arsenic exposure in this cohort of bladder cancer patients, supporting their mechanistic findings."

Capobianco is director of the Molecular Oncology Research Program in the Division of Surgical Oncology at the Sylvester Comprehensive Cancer Center, University of Miami, and was not associated with this study.

"This report is the first to link arsenic exposure to activation of the signaling pathway and its potential mediator of arsenic-driven tumors," he said.


'/>"/>

Contact: Tara Yates
tara.yates@aacr.org
267-646-0558
American Association for Cancer Research
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. Store-bought freshwater fish contain elevated levels of mercury, arsenic and selenium
2. Fetal Exposure to Arsenic Affects Genes
3. Arsenic-based therapy shown to help eradicate leukemia-initiating cells
4. People vary widely in ability to eliminate arsenic from the body
5. News brief: Arsenic biomethylation required for oxidative DNA damage
6. Acting Surgeon General Announces National Initiatives to Protect Children by Reducing Exposure to Secondhand Smoke
7. Penn School of Medicine receives $2.3 million to study biomarkers of cigarette smoke exposure
8. Teamsters Applaud Passage of Legislation to Protect Workers From Diacetyl Exposure
9. R rating might be unlikely to affect teens exposure to smoking in movies
10. Occupational exposures may be linked to death from autoimmune disease
11. Low Lead Exposures Can Hurt Kidneys
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Arsenic exposure activates an oncogenic signaling pathway; leads to increased cancer risk
(Date:10/18/2014)... Dallas, Texas (PRWEB) October 18, 2014 ... increase in government and NGO initiatives, which are making ... guidelines and reimbursement policies make the organ donation process ... Organ Preservation Solutions market to grow at ... According to the report, one of the major drivers ...
(Date:10/18/2014)... York (PRWEB) October 18, 2014 ... in a mass tort litigation now underway in ... LLP reports. According to court documents, 888 product ... on behalf of Risperdal patients who allegedly developed ... growth), due to their use of the atypical ...
(Date:10/18/2014)... determined dieters can fail if they don,t have a ... Their new study included 240 obese people. All of ... factors that increase the risk of heart disease, stroke ... to make lifestyle changes, including improved eating, the study ... clinical trial comparing two dietary interventions: the American ...
(Date:10/18/2014)... 18, 2014 As is known to ... webmasters to build websites. Recently, Best Cheap Hosting USA ... announced that Lunarpages Hosting, Bluehost and JustHost are among ... is not so easy to find a good ASP.NET ... hosting features, uptime, server speed and customer support. People ...
(Date:10/18/2014)... Sharon Ganzhorn, a radiologic technologist at Riverside Tappahannock ... an Amazon Wish List for a local animal shelter ... met, but that the community would also rally so ... a week’s time. , Thanks to Ganzhorn and ... Ganzhorn and a team of volunteers, including those from ...
Breaking Medicine News(10 mins):Health News:Organ Preservation Solutions Market to Grow at 16.85% CAGR to 2018 Forecast a New Research Report at Sandlerresearch.org 2Health News:Organ Preservation Solutions Market to Grow at 16.85% CAGR to 2018 Forecast a New Research Report at Sandlerresearch.org 3Health News:Organ Preservation Solutions Market to Grow at 16.85% CAGR to 2018 Forecast a New Research Report at Sandlerresearch.org 4Health News:Risperdal Lawsuits Mount, as Claims in Pennsylvania Litigation Near 900, Bernstein Liebhard LLP Reports 2Health News:Risperdal Lawsuits Mount, as Claims in Pennsylvania Litigation Near 900, Bernstein Liebhard LLP Reports 3Health News:Dieters May Be Thwarted by Absence of Healthy Foods 2Health News:ED Nurse at Riverside Tappahannock Hospital Orchestrates Donation of $2,500 in Pet Supplies to Local Animal Shelter 2Health News:ED Nurse at Riverside Tappahannock Hospital Orchestrates Donation of $2,500 in Pet Supplies to Local Animal Shelter 3Health News:ED Nurse at Riverside Tappahannock Hospital Orchestrates Donation of $2,500 in Pet Supplies to Local Animal Shelter 4
... by growing new cells after a heart attack. This surprising discovery ... Anversa and colleagues of the New York Medical College in Valhalla ... after a heart attack.// , ... within a few days of having a heart attack and compared ...
... Results of two new studies suggest that low-dose estrogen ... experiencing menopausal hot flushes and bleeding. The June issue ... as effective as high-dose estrogen in treating menopausal symptoms. ... irregular bleeding.// , ...
... technique to keeping heart arteries flowing easily after angioplasty ... major weakness of the common procedure.Doctors released the ... drug-coated stent. In testing on 30 patients over three ... an accomplishment almost unheard of in medicine.// ,More ...
... of the molecular controls for calcium flow in heart ... gene therapy might some day replace mechanical-assist devices or ... failure. Harvard heart researcher Dr. Roger Hajjar said many ... in heart failure in the elderly. Specifically, Hajjar and ...
... to researchers, Americans will probably have to depend on ... attack this year Second-generation vaccines are in the works ... vaccine that's ready to go, approved by the FDA.// ... maker of the anthrax vaccine to resume shipping after ...
... cell in adults that can turn into every single tissue ... that only embryonic stem cells could do this. Work is ... to turn the adult cells into tissues such as muscle, ... the patient.// ,Ihor Lemischka of the US's Princeton ...
Cached Medicine News:Health News:A ray of hope in Angioplasty dilemma 2Health News:Gene treatment maintains normal Heart Beat 2
(Date:10/17/2014)... 17, 2014 A victim of medical negligence at ... doctor with a history of alcohol abuse, a physician and ... Prop 46 today, highlighting how Prop 46 will identify and ... The ad pictures a doctor drinking at ... ER."  Proposition 46 will enact the first law in the ...
(Date:10/17/2014)... , Oct. 17, 2014  Talyst, a market ... 2014 LeadingAge Annual Meeting in Nashville, TN. ... System, the market leading solution for onsite, remote medication ... term care facilities to safely and securely dispense medication ... to first dose, helps ensure that the correct medication ...
(Date:10/17/2014)... Oct. 17, 2014  Ameritox SM , the nation,s ... of Thomas Smith , M.D., as Chief Medical ... team offering scientific resources for healthcare providers, patients and ... leadership positions at a variety of healthcare companies that ... the pain and behavioral health sides of Ameritox,s business. ...
Breaking Medicine Technology:Victim Of Negligence At Hands Of A Drunk Doctor, A Physician and Consumer Advocates Release New Yes on 46 TV Ad, "On Call" 2Victim Of Negligence At Hands Of A Drunk Doctor, A Physician and Consumer Advocates Release New Yes on 46 TV Ad, "On Call" 3Victim Of Negligence At Hands Of A Drunk Doctor, A Physician and Consumer Advocates Release New Yes on 46 TV Ad, "On Call" 4Talyst Exhibits at LeadingAge Annual Meeting 2Ameritox Appoints New Chief Medical Officer 2
For the qualitative detection of human Chorionic Gonadotrophin (hCG) in urine specimens...
For the qualitative detection of human Chorionic Gonadotrophin (HCG) in urine or urine and serum specimens...
For the qualitative detection of single and multiple drugs and drug metabolites in human urine...
ZyDoc offers a full medical transcription and documentation solution....
Medicine Products: