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Arsenic exposure activates an oncogenic signaling pathway; leads to increased cancer risk
Date:2/23/2010

signaling by decreasing the stability of the repressor form of GLI3, which is one of the transcription factors that regulate Hedgehog activity. Also, Karagas and colleagues found high levels of arsenic exposure associated with high levels of Hedgehog activity.

"Constitutive Hedgehog signaling has been implicated in a wide spectrum of solid tumors," said Anthony Capobianco, Ph.D., editorial board member of Cancer Research. "This group observed increased Hedgehog activity in a large set of human bladder tumors. Interestingly, they also detected a strong correlation between high-level Hedgehog activity and arsenic exposure in this cohort of bladder cancer patients, supporting their mechanistic findings."

Capobianco is director of the Molecular Oncology Research Program in the Division of Surgical Oncology at the Sylvester Comprehensive Cancer Center, University of Miami, and was not associated with this study.

"This report is the first to link arsenic exposure to activation of the signaling pathway and its potential mediator of arsenic-driven tumors," he said.


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Contact: Tara Yates
tara.yates@aacr.org
267-646-0558
American Association for Cancer Research
Source:Eurekalert  

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