Navigation Links
Arsenic exposure activates an oncogenic signaling pathway; leads to increased cancer risk
Date:2/23/2010

PHILADELPHIA Researchers have found a new oncogenic signaling pathway by which the environmental toxin arsenic may lead to adverse health effects, including bladder cancer. These study results are published in Cancer Research, a journal of the American Association for Cancer Research.

"In a collaborative investigation we found that arsenic, at environmentally relevant levels, is capable of activating the Hedgehog pathway and may represent a novel pathway of arsenic-associated diseases, such as bladder cancer," said Margaret R. Karagas, Ph.D., professor in the Department of Community and Family Medicine at Dartmouth Medical School.

"We provide important insight into the etiology of arsenic-induced disease, potentially relevant to the millions of people worldwide who are exposed to arsenic," she said.

Arsenic is a well-known environmental toxin and carcinogen. Studies to date have shown that individuals who live in arsenic contaminated areas of the world exhibit an elevated cancer rate. In many regions of the world, notably Taiwan, Bangladesh and Argentina, high levels of arsenic are detected in drinking water, according to Karagas. Here in the United States, Karagas said that arsenic concentrations above the current maximum contaminant level of 10 μg/L are often found in private, unregulated drinking water systems.

While the correlation between exposure to arsenic resulting in human tumors such as those derived from bladder, lung and skin is well established, the molecular mechanisms driving this connection is unclear.

Karagas and colleagues examined the hypothesis that the secreted protein called Hedgehog, a key oncogenic signaling pathway, might be activated by arsenic. Activation might underlie the mechanism by which arsenic acts as a co-carcinogen.

Using experimental data from cell cultures and results of epidemiologic studies, the researchers found that arsenic activates the Hedgehog
'/>"/>

Contact: Tara Yates
tara.yates@aacr.org
267-646-0558
American Association for Cancer Research
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. Store-bought freshwater fish contain elevated levels of mercury, arsenic and selenium
2. Fetal Exposure to Arsenic Affects Genes
3. Arsenic-based therapy shown to help eradicate leukemia-initiating cells
4. People vary widely in ability to eliminate arsenic from the body
5. News brief: Arsenic biomethylation required for oxidative DNA damage
6. Acting Surgeon General Announces National Initiatives to Protect Children by Reducing Exposure to Secondhand Smoke
7. Penn School of Medicine receives $2.3 million to study biomarkers of cigarette smoke exposure
8. Teamsters Applaud Passage of Legislation to Protect Workers From Diacetyl Exposure
9. R rating might be unlikely to affect teens exposure to smoking in movies
10. Occupational exposures may be linked to death from autoimmune disease
11. Low Lead Exposures Can Hurt Kidneys
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Arsenic exposure activates an oncogenic signaling pathway; leads to increased cancer risk
(Date:4/18/2014)... A new article published online in The ... to religious music is associated with a decrease in ... and sense of control over their lives. In particular, ... in anxiety about death and an increase in sense ... and whites, women and men, and individuals of both ...
(Date:4/18/2014)... Johns Hopkins University School of Medicine researchers have been ... for diabetes, Novo Nordisk announced this month. Of the ... and Obesity Biologics Science Forum Program, only four projects ... Hopkins researchers. They are Jonathan Powell, M.D., Ph.D.; G. ... , Jonathan Powell, a professor of oncology, will use ...
(Date:4/18/2014)... Benaroya Research Institute at Virginia Mason (BRI) recently ... molecule in metastatic breast cancer reduces both the growth ... BRI scientists have found in models of the disease ... - 80 percent and can keep the tumor from ... five-year grant comes from the National Cancer Institute of ...
(Date:4/18/2014)... 18, 2014) ― A new study in the ... in health-related Google searches reveals a recurring pattern that ... , Investigators from San Diego State University, the ... Campaigns, analyzed "healthy" Google searches (searches that included the ... originating in the U.S. from 2005 to 2012. They ...
(Date:4/18/2014)... could lead to potential new treatments for breaking the ... , Fibrosis, or scarring, is a hallmark of the ... can lead to serious organ damage and, in some ... centers on findings made by Swati Bhattacharyya, PhD, research ... a specific protein plays in promoting fibrosis. , ...
Breaking Medicine News(10 mins):Health News:Religious music brings benefit to seniors' mental health 2Health News:Benaroya Research Institute evaluates immunology approach to blocking breast cancer 2Health News:New research shows people are thinking about their health early in the week 2Health News:New clues on tissue scarring in scleroderma 2
... ... health in the Western world, the, Omega-3 story may someday be viewed ... - William S. Harris, PhD, American ... Nutrition (2003), COLUMBUS, Ohio, May 23 If anyone needed another reason,to ...
... Kicks off June 21 in Discovery Green Park, ... a top,issue in this year,s presidential election and the ... Houston Juneteenth Multicultural,Health Festival (HJMHF) will offer Houston residents ... for the entire family., The multicultural health event, ...
... -- China Sky One,Medical, Inc. (OTC Bulletin Board: ... and diagnostic products in China,today announced that its ... American Stock Exchange (AMEX). The Company expects to ... approval is contingent upon China Sky One,Medical being ...
... Patient Assignments, Prohibits, Mandatory Overtime, and Includes Initiatives to Increase Nursing ... ... The state House of Representatives voted,115 - 35 today to ... hospitals. The measure calls upon the Massachusetts,Department of Public Health to ...
... more than doubles risk while patch only increases it slightly ... hormone replacement therapy via skin patches may face a lower ... orally. , The new finding could change the risk-benefit ... hot flashes, night sweats and other symptoms of menopause. , ...
... May 22 WellCare Health Plans,Inc. (NYSE: ... its workforce to,respond to changing business conditions and ... healthcare programs., After completing a comprehensive review ... 5% of its workforce. Most of the,reductions were ...
Cached Medicine News:Health News:Announcing Another Great Reason to Eat Chocolate 2Health News:Announcing the 2nd Annual Houston Juneteenth Multicultural Health Festival 2Health News:China Sky One Medical, Inc. Approved for Listing on the American Stock Exchange 2Health News:House Passes Landmark Bill on RN Staffing and Patient Safety in Massachusetts Hospitals 2Health News:House Passes Landmark Bill on RN Staffing and Patient Safety in Massachusetts Hospitals 3Health News:House Passes Landmark Bill on RN Staffing and Patient Safety in Massachusetts Hospitals 4Health News:Patch Form of HRT Poses Less Clotting Risks Than Pill Does 2Health News:WellCare Realigns Its Workforce 2
(Date:1/15/2014)... 2014  In an unprecedented effort to curb the spread of "superbugs" ... transport vehicles, an advanced and portable UV germicidal lamp manufactured by ... time. In order to prevent EMS paramedics and ... West Palm Beach Fire Rescue is the first ...
(Date:1/15/2014)... , Jan. 15, 2014  According to Millennium Research ... market intelligence, the United States ... device markets will expand moderately through 2022, with ... In particular, increasing interest in drug-eluting beads (DEBs) ...
(Date:1/15/2014)... YORK , Jan. 15, 2014 ... market research report is available in ... Global Markets and Technologies for Advanced ... Routes of Administration ...
Breaking Medicine Technology:Superbugs No Longer Ride In Rescue Vehicles 2US and European Transcatheter Embolization and Occlusion Device Market to Surpass $1.6 Billion by 2022 2US and European Transcatheter Embolization and Occlusion Device Market to Surpass $1.6 Billion by 2022 3Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 2Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 3Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 4Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 5Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 6Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 7Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 8Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 9Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 10Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 11Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 12Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 13Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 14Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 15Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 16
Supplemental instrument to the Small Joint Arthroplasty System....
... System utilizes the same proven materials found ... The SR™ Hand Implant System provides advantages ... minimal bone resection, surface replacement of the ... and/or repositioning of the ligamentous soft tissues, ...
Anatomic implant shape and easy-to use instrumentation promote implant alignment, stability, and restored joint kinematics....
The NeurOptics Pupillometer is a portable instrument used to measure pupils to screen candidates for refractive procedures and other ophthalmic applications....
Medicine Products: