Navigation Links
Arsenic-based therapy shown to help eradicate leukemia-initiating cells
Date:5/12/2008

BOSTON -- In both leukemia and solid tumors, there exists among the multitude of warrior cancer cells a small subgroup that work undercover, patiently lying in wait to launch their attacks. Known as either cancer initiating cells (CICs) or leukemia initiating cells (LICs), these stealth populations are impervious to conventional chemotherapy and undaunted by targeted cancer therapies. When a leukemia patient relapses following a period of remission, it is the LICs that bear responsibility for the diseases reemergence.

The secret to the survival abilities of these cells has been unclear. But in a paradoxical discovery, a research team led by investigators at Beth Israel Deaconess Medical Center (BIDMC) has found that a tumor suppressor protein known as PML appears to be the factor that enables LICs to maintain their quiescence the inert state that protects them from being destroyed by cancer therapies and suggests that inhibition of PML is a promising target for new therapeutics.

Their findings, which appear in todays advance on-line issue of the journal Nature, additionally demonstrate that PML can be degraded with an arsenic-based agent used in traditional Chinese medicine. Importantly, when combined with chemotherapy, the arsenic-based therapy -- already proven safe and non-toxic in clinical trials -- can successfully treat chronic myeloid leukemia.

Leukemia initiating cells share many properties of normal hematopoetic stem cells, explains senior author Pier Paolo Pandolfi, MD, PhD, Director of the Cancer Genetics Program in BIDMCs Cancer Center and Professor of Medicine and of Pathology at Harvard Medical School. They are pluripotent, they readily replicate and they can indefinitely remain in a dormant state of quiescence.

Consequently, while the majority of leukemic cells are vulnerable to any cancer therapies including chemotherapy and targeted cancer treatments that destroy cells during active DNA replication, L
'/>"/>

Contact: Bonnie Prescott
bprescot@bidmc.harvard.edu
617-667-7306
Beth Israel Deaconess Medical Center
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. FDA Says, Wait To Dying Men; Coast-To-Coast Prostate Cancer Demonstrations on May 30th in Protest of FDA Failure to Approve Safe, Effective Immunotherapy
2. Skin flaps deliver cancer-fighting therapy, ASPS study reveals
3. UAB first in US to offer speedier precise cancer radiotherapy
4. Virtual Reality Therapy May Help PTSD Patients
5. Kidney disease worsens in a fourth of African-Americans despite therapy for hypertension
6. Leveraging CVIS Integration to Automate Anticoagulation Therapy Webinar
7. New OPAL Therapy presents simple, cost-effective method of treating HIV infection
8. Promising early evidence of the superior benefits of drug therapy for diabetic eye disease
9. American Humane Forms Human-Animal Bond Division, Including Animal-Assisted Therapy, Humane Ed and Pets & Womens Shelters
10. Immune-Boosting Lung Cancer Therapy Shows Promise
11. Varian Medical Systems Announces Record Demand for New RapidArc(TM) Radiotherapy Treatment Capability
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/9/2014)... (PHILADELPHIA) Researchers at the Perelman School of Medicine ... Roswell Park Cancer Institute have received an $8 million ... the effects of photodynamic light therapy (PDT) in patients ... cancer that most often manifests itself in the lining ... exposure to asbestos. The grant will fund a clinical ...
(Date:7/9/2014)... network of signals active in almost all types of ... overdrive, and may help fuel a tumour,s uncontrolled growth, ... Cancer Research, London, identified a molecular trigger responsible for ... the cellular factory that makes the building blocks cancer ... the TOR signalling pathway, called SREBP, controls the flow ...
(Date:7/9/2014)... cancer, researchers have uncovered mutations in a cell-signaling pathway ... knowledge may expand treatments for patients because drugs targeting ... are in clinical trials. , Reporting July 9 in ... (TCGA), including researchers at Washington University School of Medicine ... studied tumors from 230 patients with lung adenocarcinoma. , ...
(Date:7/9/2014)... Chase Cancer Center paint a relatively optimistic picture of ... that have spread to the chest wall or skin, ... the skin, regardless of size and whether they have ... and called "locally advanced" tumors, suggesting that they ... poor survival. Locally advanced breast cancers of this and ...
(Date:7/9/2014)... used in policing injection drug users in Russia ... , A study, conducted by researchers from ... in collaboration with St. Petersburg Pavlov State University, ... on the health outcomes of a cohort of ... , Those who were arrested by police were ...
Breaking Medicine News(10 mins):Health News:Penn mesothelioma program receives $8 million NCI grant 2Health News:Signal may send cancer's cellular factories into overdrive 2Health News:Lung cancer study hints at new treatments 2Health News:Fox Chase researchers recommend updating the staging criteria for breast cancer diagnoses 2Health News:Fox Chase researchers recommend updating the staging criteria for breast cancer diagnoses 3Health News:BU researchers relate arrests with HIV risk environment 2
... Oct. 15 With the Centers for Disease Control and ... now spread throughout the United States, the American Red Cross ... or are taking care of someone who has the flu. ... person to person in droplets of coughs or sneezes, and ...
... 15 Americans without health insurance are one major illness ... research by the Kellogg School of Management at Northwestern University ... major health concern, such as heart disease, cancer or a ... in order to pay their medical expenses. , ...
... a Medical College of Georgia resident and faculty member may ... circumstances. About 2 percent of patients that undergo the ... performed in an emergency situation or prior to surgery. ... and uses a metal scope to open the mouth and ...
... Smoking bans are effective at reducing the risk of ... secondhand smoke, says a new report from the Institute ... sufficient evidence that breathing secondhand smoke boosts nonsmokers, risk ... even relatively brief exposures could lead to a heart ...
... Past President of the New Jersey Obstetrical and Gynecological Society ... 15 According to NAMS (North American Menopause Society), 6,000 ... a year. For the majority of women, hot flashes, ... For years, women have searched for a treatment that ...
... beautifully clear, acne-free skin, naturally? Skip the synthetics and ... Bees(®) Natural Acne Solutions(TM) products. , To view the ... , (Photo: http://www.newscom.com/cgi-bin/prnh/20091015/NY92770 ) ... truly natural* acne line clinically proven to help ...
Cached Medicine News:Health News:Red Cross Offers Important Tips for Caring for Someone With the Flu 2Health News:Red Cross Offers Important Tips for Caring for Someone With the Flu 3Health News:The Effects of Health on Wealth: New Study Reveals Individuals Without Health Insurance at Risk for 'Financial Catastrophe' 2Health News:The Effects of Health on Wealth: New Study Reveals Individuals Without Health Insurance at Risk for 'Financial Catastrophe' 3Health News:New laryngoscope could make difficult intubations easier 2Health News:Smoking bans reduce the risk of heart attacks associated with secondhand smoke 2Health News:On World Menopause Day, October 18, The International Menopause Society and World Health Organization Urge Women to Learn About Their Options for Dealing With Menopause 2Health News:On World Menopause Day, October 18, The International Menopause Society and World Health Organization Urge Women to Learn About Their Options for Dealing With Menopause 3Health News:Video: Introducing Natural Acne Solutions(TM) By Burt's Bees(R) 2
(Date:1/15/2014)...  Humberto C. Antunes,  Galderma  worldwide CEO, will receive a ... of Drugs in Dermatology (JDD) at the upcoming ... is January 17-20, 2014, at the Omni Orlando Resort at ChampionsGate ... The ODAC is a distinguished event that delivers a ...
(Date:1/15/2014)...  In an unprecedented effort to curb the spread of "superbugs" such ... vehicles, an advanced and portable UV germicidal lamp manufactured by MRSA-UV ... In order to prevent EMS paramedics and transport ... West Palm Beach Fire Rescue is the first in ...
(Date:1/15/2014)... Inc. (Nasdaq: ECTE ) ("Echo"), a medical ... non-invasive, wireless continuous glucose monitoring system, today announced that ... CEO of Echo Therapeutics, will present at "TEN", Noble ... Mr. Doman will make a corporate presentation to ...
Breaking Medicine Technology:Galderma's global leader honored with a "Lifetime in Dermatology Achievement Award" by Journal of Drugs in Dermatology 2Galderma's global leader honored with a "Lifetime in Dermatology Achievement Award" by Journal of Drugs in Dermatology 3Galderma's global leader honored with a "Lifetime in Dermatology Achievement Award" by Journal of Drugs in Dermatology 4Superbugs No Longer Ride In Rescue Vehicles 2Echo Therapeutics to Present at the Noble Financial Capital Markets' Tenth Annual Equity Conference 2Echo Therapeutics to Present at the Noble Financial Capital Markets' Tenth Annual Equity Conference 3
... 17 The following letter is being released ... , Dear Fellow Shareholders: , We are pleased to report to you ... ever. During this difficult time we were able to complete and validate ... being able to manufacture Multikine for the Phase III clinical trial.  We ...
... , RALEIGH, N.C. , Feb. ... training solutions for the pharmaceutical and biotech industry, today announced ... and Retail Pharmacy .  The courses, developed in partnership ... to the company,s Managed Markets Excellence® Series, a ...
Cached Medicine Technology:CEL-SCI Corporation Releases Letter to Shareholders 2CEL-SCI Corporation Releases Letter to Shareholders 3CEL-SCI Corporation Releases Letter to Shareholders 4CEL-SCI Corporation Releases Letter to Shareholders 5CEL-SCI Corporation Releases Letter to Shareholders 6Pharmaceutical Institute Launches New Training Resources Focused on Employers and Retail Pharmacy 2Pharmaceutical Institute Launches New Training Resources Focused on Employers and Retail Pharmacy 3
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: