Navigation Links
Arrival of direct antiviral agent therapy for hepatitis C sparks debate of who to treat first
Date:5/25/2011

For many patients with the hepatitis C virus (HCV), direct antiviral agents (DAA) offer a potential cure for the disease. The Food and Drug Administration (FDA) has recently approved two new DAAs, telaprevir and boceprevir, and with that clinicians must now decide who should be the first to receive this treatment. Discussion of this timely topic is now available in the June issue of Hepatology, a journal published by Wiley-Blackwell on behalf of the American Association for the Study of Liver Diseases.

The World Health Organization (WHO) estimates up to 170,000 million individuals worldwide are infected with chronic HCV. In the U.S., HCV is the leading cause of liver-related mortality and most common cause for liver transplantation. Medical evidence has shown that for the past ten years response rates to pegylated interferon and ribavirin treatment have been stagnant, with less than half of patients achieving a sustained virologic response. Now with the introduction of new DAA therapy, it is expected to significantly improve virus clearance rates, particularly in patients with genotype 1, compared to the current standard of care.

"The availability of DAA therapy will forever change the landscape of HCV," explains Andrew Aronsohn, M.D., from the University of Chicago Medical center and co-author of the current paper. "We will now be able to cure patients of HCV disease who we were unable to cure in the past." However, as the authors note, the medical breakthrough with DAAs is coupled with resource scarcity and an equitable distribution based upon medical need is essential.

DAA therapy and its promise to improve efficacy has been well publicized for a number of years, prompting clinicians and patients to defer standard care in cases where there was a low risk of HCV progressing to severe liver disease. The authors point out that in one large study of 4084 patients evaluated for HCV therapy with interferon and ribavirin, of those that declined therapy more than half did so in anticipation of more effective therapy.

The advent of DAAs will likely create a surge in requests to initiate treatment given the number of patients who deferred treatment, along with those patients who failed to respond to standard HCV regiments. The authors performed a time analysis study at their institution to understand the time needed to treat patients with DAA therapy. They found that on average, a health care provider could initiate therapy on three patients each week, and at least 500 requests for evaluation of HCV therapy are anticipated during the first few weeks of DAA availability. "Current staffing will be unable to meet the demands of all HCV patients requesting treatment," concluded co-author, Donald Jensen, M.D. "We propose a plan to educate patients and triage therapy to the neediest patients first, thereby fulfilling the moral framework of distributive justice."


'/>"/>

Contact: Dawn Peters
healthnews@wiley.com
781-388-8408
Wiley-Blackwell
Source:Eurekalert

Related medicine news :

1. A direct path for understanding and treating brittle bones
2. Legendary Hollywood directors and renowned researchers awarded 2011 Dan David Prizes
3. Wistar researchers: Direct proof of how T cells stay in standby mode
4. New direction for epilepsy treatment
5. Center director says FDA hitting milestones in tobacco law
6. How we manage water resources has a direct impact on our health, says Canada Research Chair
7. Using pharmacist-directed service improves quality of care for patients
8. Cedars-Sinai Medical Genetics Institute director honored with lifetime achievement award
9. U-M researchers find indirect path to attack breast cancer stem cells
10. Oncology basic research director at John Theurer Cancer Center continues transplantation research
11. Drop in breast cancer rates directly tied to reduced hormone therapy
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/24/2017)... Mass. (PRWEB) , ... January 24, 2017 , ... ... company to visualize, detect, and eliminate cyber threats in real-time, today announced a ... This partnership will enable customers to monitor, respond and protect their critical information ...
(Date:1/24/2017)... (PRWEB) , ... January 24, 2017 , ... Center ... 21st century leadership, has named Hector M. Chavez, Manager, Employee & Labor Relations at ... center - as its Hispanic Leader of the Month. City of Hope is committed ...
(Date:1/24/2017)... Santa Rosa, CA (PRWEB) , ... January 24, 2017 , ... ... rates is good news for everyone and particularly good news for prostate cancer patients: ... from the diagnosis. , According to the report the cancer death rate has dropped ...
(Date:1/24/2017)... ... January 24, 2017 , ... A yellow fever outbreak in Brazil ... month. Yellow fever is primarily spread through contact with infected mosquitos. The outbreak has ... to prevent its spread. , According to multiple health organizations, the best way to ...
(Date:1/24/2017)... ... January 24, 2017 , ... “Spiritual Vitamins: ... the connection with God. “Spiritual Vitamins: A Spiritual Energy Booster” is the creation ... Faith Publishing, Mathai Yohannan’s new book engages the mind and spirit in a ...
Breaking Medicine News(10 mins):
(Date:1/24/2017)... -- www.Financialbuzz.com - The cannabis market ... the United States as eight more states had ... 64, the California Cannabis Legalization Initiative, was passed by a ... 2016. This outcome means that individuals in California ... certain amount of cannabis for personal use. According to a ...
(Date:1/24/2017)... 2017   QR Pharma , Inc., a ... therapies for the treatment of Alzheimer,s, Parkinson,s and ... four world-class key opinion leaders to its Scientific ... Pharma,s previous roster of impressive advisors in order ... the development of the breakthrough mechanism of action ...
(Date:1/24/2017)... Mezzion has filed a suit for damages ... that Dr. Reddy,s committed fraud relating to Dr. Reddy,s ... (FDA) cGMP practices, and misrepresenting its compliance to Mezzion.  ... Mezzion that it was compliant with FDA regulations, and ... also states that Dr. Reddy,s misconduct was the sole ...
Breaking Medicine Technology: