Navigation Links
Aromatase inhibitor letrozole guards against breast cancer relapse for up to 8 years
Date:9/25/2011

Stockholm, Sweden: Results from the longest-running trial comparing tamoxifen with the aromatase inhibitor letrozole show unequivocally that letrozole has withstood the test of time and continues to prevent breast cancer recurrences and reduce the risk of death in post-menopausal women with hormone receptor-positive early breast cancer.

Professor Richard Gelber told delegates at the 2011 European Multidisciplinary Cancer Congress [1], in Stockholm today (Monday 26 September) that a 12-year update of results from the Breast International Group (BIG) 1-98 [2] trial showed that if women with early breast cancer (cancer that has not spread from the breast) were given letrozole after surgery for at least five years, they continued to do better and have fewer recurrences of the disease than those who were given tamoxifen.

"Over a median of eight years of follow-up, women who were assigned to receive five years of letrozole after surgery had an 18% reduced risk of relapse and a 21% reduced risk of death compared with those assigned to receive tamoxifen," said Prof Gelber, Director of the International Breast Cancer Study Group (IBCSG) Statistical and Data Management Center at the Dana-Farber Cancer Institute, Boston, MA, USA.

"The current 12-year update is the longest follow-up to date and includes much more information than we had after ten years. For instance, there have been 32% more relapses and 39% more deaths since the ten-year update, which increases substantially the reliability of the results and provides reassurance regarding the long-term value of letrozole. This additional follow-up and accumulation of information on relapses and deaths show that the overall survival advantage for adjuvant letrozole compared to tamoxifen continues to be statistically significant."

Adjuvant therapy (treatment that is given after surgery), using drugs that target hormones such as oestrogen, is given to patients with early breast cancer who
'/>"/>

Contact: Kay Roche
kayroche@gmail.com
ECCO-the European CanCer Organisation
Source:Eurekalert

Page: 1 2 3 4

Related medicine news :

1. Study sheds light on aromatase inhibitor joint pain syndrome
2. University of Michigan scientists identify chemical in bananas as potent inhibitor of HIV infection
3. Patients Who Take a Proton-Pump Inhibitor With Medicine to Prevent Blood Clots Are Less Likely to Be Hospitalized for Bleeding Ulcers
4. BRAF inhibitor shows promising preclinical activity against melanoma
5. JAK inhibitor provides rapid, durable relief for myelofibrosis patients
6. Novel biomarker may predict response to new VEGF receptor inhibitor
7. Afatinib benefits lung cancer patients whose cancer progressed after treatment with EGFR inhibitors
8. PARP inhibitor, MK-4827, shows anti-tumor activity in first trial in humans
9. JAK inhibitors producing significant response in myelofibrosis patients
10. Current smokers with early rheumatoid arthritis less responsive to TNF inhibitors, methotrexate
11. Combining 2 peptide inhibitors might block tumor growth
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/29/2015)... ... August 29, 2015 , ... Next weekend is Labor Day weekend, the ... ends on September 22nd this year). For IT security personnel, it should also mark ... could prove far more costly than a simple headache. , Joe Caruso, founder and ...
(Date:8/29/2015)... ... ... The popular television program VOICES IN AMERICA, hosted by legendary star of ... an entire short segment to the subject of diabetes. Diabetes is a debilitating health ... basis, but recent advancements in medical science may prove to be a significant breakthrough ...
(Date:8/28/2015)... ... August 28, 2015 , ... An online provider of ... make the purchase of CPAP equipment more affordable by offering shipping at no cost ... of CPAP products and orders of any size. My Cpap Store is located in ...
(Date:8/28/2015)... ... , ... With the goal of furthering music education programs in schools, the ... County Fairgrounds in Mendon, IL on May 30th, 2015. Backed once again by Best ... the underfunded school districts of Mendon and its neighboring town of Quincy, IL. Best ...
(Date:8/28/2015)... Hanover, MA (PRWEB) , ... August 28, 2015 , ... ... benefitting the renowned Brain Aneurysm Foundation has added yet another accolade to its ... Chicago, Rahm Emanuel. , “With the help of the medical community and ...
Breaking Medicine News(10 mins):Health News:Business Cyber Security – Come Out of the Summer with a Clean Slate 2Health News:Business Cyber Security – Come Out of the Summer with a Clean Slate 3Health News:Business Cyber Security – Come Out of the Summer with a Clean Slate 4Health News:My Cpap Store Now Offering Delivery Special 0 Cost to You 2Health News:Best Drug Rehabilitation Interviews Country-Rock Duo Highway Run at the 2015 "Music With A Mission" Benefit Concert 2Health News:Chicago Mayor Pens Official Support of Annual Survivor in the City Event Benefitting Brain Aneurysm Foundation 2Health News:Chicago Mayor Pens Official Support of Annual Survivor in the City Event Benefitting Brain Aneurysm Foundation 3
... suffering from serious hearing problems could have been benefited by ... is keeping them away, health experts said Saturday. ... hearing problems and about a million are children and they ... of the device is proving a hindrance," said Vice Admiral ...
... of Illinois at Urbana-Champaign have developed a simple, disposable ... rivals the performance of much more sophisticated laboratory instruments. ... test for assessing uranium contamination in the environment, and ... chemistry professor at Illinois and senior author of a ...
... its symbol back.It has notified public sector Indian Oil Corporation (IOC) ... using its red-colored cross symbol at pump outlets and other services ... chairman of Indian Oil telling him to direct petrol pump owners ... for the IRCS. ,The Geneva Conventions Act of 1960 ...
... is said to be vulnerable to a specific health ... colleagues from Institute for Clinical Evaluative Sciences in Toronto. ... more prone to pelvic fractures and Pisceans should be ... women born under the sign of Virgo vomit more ...
... A new lasercomb which promises hair growth in the scalp ... as Hairmax Lasercomb is manufactured by Lexington International LLC, a ... of low-level laser technology in a comb which when passed ... used by both men and women. The company’s website reveals ...
... their heart's content, brave young hearts battling cancer and those ... message - the disease is curable. ,The occasion ... Day. ,Prabhasimran Anand, a bubbly eight-year-old, who is ... "I am fighting blood cancer. I also go to school ...
Cached Medicine News:Health News:Need for Cost-effective Hearing Implants 2Health News:DNA-based Detection of Heavy Metals 2Health News:Health Disorders Linked To Astrological Signs 2Health News:Spirited, Smiling Young Warriors Take on Cancer 2
(Date:8/28/2015)... Aug. 28, 2015  Delays in the launch ... slow down the decision-making process, resulting in missed ... critical for biopharmaceutical companies to develop a tactical ... for quicker and more meaningful insights. ... LLC, nearly three-quarters of benchmarked study participants use ...
(Date:8/28/2015)... DUBLIN , Aug. 28, 2015 ... ) has announced the addition of the ... report to their offering. Originally discovered ... as Yoshitomi Pharmaceutical Industries, Ltd) as an inflammatory ... by Senju Pharmaceutical Co., Ltd under the trade ...
(Date:8/28/2015)... 2015 Research and Markets ... "Investigation Report on China,s Tobramycin Market, 2010-2019" ... traditional antibiotic whose eye drop and ointment are the ... infection or inflammation caused by eye infection. Currently, dozens ... able to produce tobramycin, among which the Top 5 ...
Breaking Medicine Technology:Expediting the Pharmaceutical Market Research Process for Faster Insights 2Investigation Report on China's Pranoprofen Market, 2010-2019 2Investigation Report on China's Tobramycin Market, 2015-2019 2
... Mindray Medical International Limited (NYSE: MR ), ... worldwide, today announced the introduction of the company,s new ... and white portable unit provides outstanding imaging quality in ... numerous specialty markets. With DP-50,s launch, Mindray has expanded ...
... LONDON, September 16, 2011 Concateno Welcomes the Campaign ... th July, John Page was sentenced to eight months in prison ... Page,s vehicle hit Lillian while she was playing outside her home in ... the time of the accident, police also found a half-smoked cannabis joint ...
Cached Medicine Technology:Mindray Introduces DP-50 Portable Ultrasound System in the U.S. 2Mindray Introduces DP-50 Portable Ultrasound System in the U.S. 3Drug-Driving: Draw the Line Now 2Drug-Driving: Draw the Line Now 3Drug-Driving: Draw the Line Now 4
... The Stryker Cross-Screw System ... and secure method for ACL ... The Stryker Cross-Screw System provides ... fixation. The implant comes in ...
... Universal Wedge Screw is a ... cruciate reconstruction and is indicated ... grafts. The Universal Wedge Screw ... has blunt threads which protect ...
... The Stryker Threaded ... surgeon yet another choice ... tunnel. Dilators provide compaction ... The compaction of bone ...
... The Stryker Conquest Suture ... instruments that pierce through ... suture through the tissue ... The Conquest Retrievers are ...
Medicine Products: