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Army researcher develops potential vaccine carrier
Date:4/22/2012

"Microemulsions are very sensitive to change. If you add an extra compound, they (also) separate quickly," he said. "But what I discovered is that, if I take an aluminum adjuvant, which is the only one approved by the (Food and Drug Administration) to be used in humans, and I mix that microemulsion with the aluminum compound, it is still stable."

The aluminum adjuvant Muderhwa used is found in the influenza vaccine.

While microemulsions are now used for drug delivery, such as antibiotics and syrups, using them for vaccines could open up a new area of study, Maj. Muderhwa said. These microemulsions are formed readily and sometimes spontaneously, he said.

"Another part of the presentation is for the future to tell people that these products can be used as a tool to investigate the effect of the surface area on the immune response," he explained. "If you make the molecules smaller and smaller and smaller, what happens? What happens if you increase the surface area? It will be interesting for research purposes to see the effects when the surface area increases on the immune response using this compound."


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Contact: Angela Hopp
ahopp@asbmb.org
713-471-4541
American Society for Biochemistry and Molecular Biology
Source:Eurekalert  

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Army researcher develops potential vaccine carrier
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