Navigation Links
Arete Therapeutics Presents Positive Clinical and Preclinical Data for AR9281
Date:6/9/2009

e Epoxide Hydrolase Inhibitor - Efficacy in a DIO Mouse Model plus Pharmacokinetics and Pharmacodynamics in Mice and Men" (Whitcomb, R, Chen, D, Wang, J, Anandan, S-K, Gless, R and Webb, H). This poster describes the direct correlation between the concentration of AR9281 in blood and the activity of its target, sEH, in both mice and humans. The data further demonstrate that AR9281 improves glucose metabolism in rodent models of type 2 diabetes. -- "A Novel Inhibitor of Soluble Epoxide Hydrolase, AR9281, Improves Glucose Homeostasis in Diet-Induced Obese Mice" (Wong, K, Zhang, L-N, Vincelette, J, Chen, D, Mehra, U, Cheng, Y, Gless, R, Anandan, S-K, Webb, H). Data presented in this poster show that in diet-induced obese mice, AR9281 inhibits sEH and improves glucose tolerance in a highly-dose dependent manner. Improvement of glucose tolerance by AR9281 is not observed in sEH knock-out mice indicating that the action of AR9281 is sEH mechanism-based. These positive effects are associated with reductions in plasma insulin, IL-6, an inflammatory molecule elevated in people with type 2 diabetes, and resistin, a hormone that plays a role in predisposing obese individuals to diabetes. -- "Improvement of Glucose Homeostasis by AR9281, a Novel Inhibitor of Soluble Epoxide Hydrolase, in Diet-Induced Obese Mice Does Not Depend on Active Nitric Oxide Synthase" (Vincelette, J, Chen, D, Mehra, U, Cheng, Y, Gless, R, Anandan, S-K, MacIntyre, E and Wang, J). Data presented in this poster show the correlation between treatment with AR9281 and the lowering of the glucose levels after an oral glucose tolerance test and demonstrate that these effects are not inhibited by concurrent treatment with the nitric oxide synthase inhibitor L-NAME (NG-nitro-L-arginine methyl est
'/>"/>
SOURCE Arete Therapeutics Inc.
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine news :

1. CareTech Receives National Recognition in 2009 Aster Awards for Medical Marketing Excellence
2. CareTech Solutions Launches Robust Service Desk Solution to Support Clinical Applications and Technology within Continuum Health Partners Hospitals
3. CareTech Solutions Caps Banner Year by Signing Pennsylvanias Lehigh Valley Health Network, Tennessees Covenant Health, and Ohios Marietta Memorial Hospital to Provide Web Services
4. Arete Therapeutics Initiates Phase IIa Clinical Trial for AR9281, a Novel s-EH Inhibitor to Treat Type 2 Diabetes
5. EnovateIT Partners with CareTech Solutions to Create a Custom Product for Crittenton Hospital Medical Center, One of the Nation's Most Wired Hospitals
6. CareTech Solutions Named Best in KLAS for Extensive IT Outsourcing Services
7. Nationally Recognized Diabetes Specialist Dr. Steven Edelman to Provide Educational Articles on Diabetes to MyCareTeam's Website Community
8. CareTech Solutions Service Desk Equals Help Desk Plus
9. Arete Therapeutics Appoints Donald Santel to Board of Directors
10. Arete Therapeutics Initiates Phase 1 Clinical Trial For AR9281 as a First-in-Class Antihypertensive Agent
11. CareTech Solutions Executive to Conduct Presentation on Creating a Healthy Revenue Cycle at AHIMA Convention and Exhibit
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/17/2014)... 17, 2014 In a continuing effort ... Nile virus threats, Mosquito Shield of the South Shore ... with the Hanover Youth Athletic Association to treat area ... daily practices going until dusk, prime mosquito feeding time, ... athletes, coaches, and parents involved in outdoor athletic activities. ...
(Date:9/17/2014)... 2014 Stand Up for Heroes, New ... to the Theater at Madison Square Garden, Wednesday, Nov. ... Foundation (BWF) and New York Comedy Festival (NYCF), the ... veterans and their families. , The charitable event ... Oliver, Bruce Springsteen, Brian Williams and other surprise guests. ...
(Date:9/17/2014)... (PRWEB) September 17, 2014 Health ... increase efficiency. Today, Pharmacy Healthcare Solutions, a wholly ... web-based analysis and forecasting tool that enables hospitals ... the impact of medications on improved patient outcomes. ... uses pharmacy purchase data to identify areas of ...
(Date:9/17/2014)... 16, 2014) A study led by St. Jude ... dose threshold below which male childhood cancer survivors ... study appears in September 17 edition of the ... which patients are at highest risk for reduced ... to eventually increase use of pre-treatment fertility preservation ...
(Date:9/17/2014)... (PRWEB) September 17, 2014 MarijuanaStock.net, ... http://www.marijuanastock.net , recently launched a “Video” section that ... cannabis companies in the marijuana industry made available ... a website visitor is given access to numerous ... to marijuana-related businesses and the issues they face. ...
Breaking Medicine News(10 mins):Health News:Mosquito Shield of South Shore Again Partners with Hanover Youth Athletic Association 2Health News:Louis C.K., John Mulaney, John Oliver, Bruce Springsteen, Brian Williams & More to Perform at 8th Annual Stand Up for Heroes at Theater at Madison Square Garden, Nov. 5 2Health News:Louis C.K., John Mulaney, John Oliver, Bruce Springsteen, Brian Williams & More to Perform at 8th Annual Stand Up for Heroes at Theater at Madison Square Garden, Nov. 5 3Health News:Louis C.K., John Mulaney, John Oliver, Bruce Springsteen, Brian Williams & More to Perform at 8th Annual Stand Up for Heroes at Theater at Madison Square Garden, Nov. 5 4Health News:Louis C.K., John Mulaney, John Oliver, Bruce Springsteen, Brian Williams & More to Perform at 8th Annual Stand Up for Heroes at Theater at Madison Square Garden, Nov. 5 5Health News:Pharmacy Healthcare Solutions Launches TARxGET™ Reporting 2Health News:Pharmacy Healthcare Solutions Launches TARxGET™ Reporting 3Health News:Improved risk identification will aid fertility preservation in young male cancer patients 2Health News:Improved risk identification will aid fertility preservation in young male cancer patients 3Health News:MarijuanaStock.net Adds Business News Video Section to Their Website 2
... drilling, new energy technologies, science at the LHC, tests of gravity ... edge science will be featured in talks at this year,s April ... April 30 to May 3 at the Hyatt Hotel Orange County ... free of charge. Registration information can be found at the end ...
... be at increased risk of damage to the same brain ... by researchers at Washington University School of Medicine in St. ... that scientists have linked to neurological problems including Parkinson,s disease-like ... than 1 million workers who perform welding as a part ...
... the School of Public Health at the University of ... of depression may have long-term benefits. The data ... a longitudinal Canadian study, and showed depressed adults who ... depressed eight years later, compared to depressed adults who ...
... , WEDNESDAY, April 6 (HealthDay News) -- Long-term users ... damage, warns a new study. Brain scans showed an ... and a lower proportion of overall gray matter among long-term ... that people who use ecstasy can develop serious memory problems, ...
... THURSDAY, April 7 (HealthDay News) -- For American parents, doctors ... of children,s vaccines, a new study indicates. Researchers conducted ... and younger, and found that 76 percent said they trusted ... information about vaccine safety. Other sources trusted "a lot" ...
... (HealthDay News) -- A new report reveals that 98.8 percent ... to 64 with untreated alcohol abuse disorders don,t believe they ... nearly 6 million American adults with untreated alcohol dependence recognize ... to increase public awareness about adult problem drinking, how to ...
Cached Medicine News:Health News:Nuclear security, deep water drilling, black hole signal flares and more at 2011 APS annual meeting 2Health News:Nuclear security, deep water drilling, black hole signal flares and more at 2011 APS annual meeting 3Health News:Nuclear security, deep water drilling, black hole signal flares and more at 2011 APS annual meeting 4Health News:Nuclear security, deep water drilling, black hole signal flares and more at 2011 APS annual meeting 5Health News:Nuclear security, deep water drilling, black hole signal flares and more at 2011 APS annual meeting 6Health News:Nuclear security, deep water drilling, black hole signal flares and more at 2011 APS annual meeting 7Health News:Nuclear security, deep water drilling, black hole signal flares and more at 2011 APS annual meeting 8Health News:Welders may be at increased risk for brain damage 2Health News:Treatment for depression a long-term solution 2Health News:Long-Term Ecstasy Users at Risk for Brain Damage, Study Warns 2Health News:Doctors Most Trusted Source of Vaccine Information, Study Finds 2Health News:Only 1.2% of Alcohol Abusers Know They Need Help: Report 2
(Date:9/17/2014)... 2014  Millions of people suffer from neck and arm ... Recently the FDA approved the launch of a clinical ... device developed by Spinal Kinetics, which may offer relief to ... arm pain. Hospital for Special Surgery (HSS), the number one ... New York City and in the ...
(Date:9/17/2014)... Texas , Sept. 17, 2014  Lightbeam ... Direct Accountable Care Organization (Physician Direct ACO) to ... their physicians in providing better care while reducing ... Physician Direct Accountable Care Organization ... Network Services (OPNS). The OPNS mission is to ...
(Date:9/17/2014)... COLUMBUS, Ohio , Sept. 17, 2014 /PRNewswire/ ... Riverside Radiology and Interventional Associates announced today ... Systems to enhance its image sharing capabilities ... case of any network failures. In addition, the ... to help navigate disparate PACS systems to more ...
Breaking Medicine Technology:Cervical Disc Clinical Trial for People with Neck and Arm Pain Set to Begin at Hospital for Special Surgery 2Physician Direct Accountable Care Organization Selects Lightbeam Health to Enable Better Care at a Lower Cost 2Physician Direct Accountable Care Organization Selects Lightbeam Health to Enable Better Care at a Lower Cost 3Dicom Systems' Innovative Software Provides Enhanced Imaging Sharing Capabilities, as Well as Connection Reliability in the Case of Network Failure 2Dicom Systems' Innovative Software Provides Enhanced Imaging Sharing Capabilities, as Well as Connection Reliability in the Case of Network Failure 3
... N.J., Oct. 27 Watson Pharmaceuticals, Inc. (NYSE: ... Laboratories, Inc., filed a new drug application under Section ... (FFDCA) with the U.S. Food and Drug Administration (FDA) ... and 40 mg tablets.  Watson,s rosuvastatin zinc tablets are ...
... Oct. 27 Intrinsic Bioprobes today announced that ... issued US Patent 7,816,095 covering novel blood protein ... first of a series of patent applications that ... clinical utility. "The biomarkers were discovered ...
Cached Medicine Technology:Watson Confirms Crestor® Patent Challenge 2Intrinsic Bioprobes Announces Issuance of US Patent for Novel Biomarkers and Assays for Myocardial Infarction 2
... Bird and Cronin, Inc. ... of Patient Footwear, Orthopedic ... Care Products. Our products ... quality and available in ...
... Aspen® CTO combines highly effective immobilization of ... a level of comfort that makes it ... substantially progressive immobilization in going from a ... and then on to a four-post orthosis. ...
... Shoulder Immobilizer with Contoured ... Navy cotton sling with foam-padded ... body straps. Quick-release closure buckles. ... 35 covered abduction wedge to ...
The Humeral Stabilizing System is a terrific option for immobilization of stable humeral fractures, stablesupracondular fractures, and biceps/triceps repairs....
Medicine Products: