Arete Therapeutics Presents Positive Clinical and Preclinical Data ...(e Epoxide Hydrolase Inhibitor - Efficacy...),Health

Date:6/9/2009

e Epoxide Hydrolase Inhibitor - Efficacy in a DIO Mouse Model plus Pharmacokinetics and Pharmacodynamics in Mice and Men" (Whitcomb, R, Chen, D, Wang, J, Anandan, S-K, Gless, R and Webb, H). This poster describes the direct correlation between the concentration of AR9281 in blood and the activity of its target, sEH, in both mice and humans. The data further demonstrate that AR9281 improves glucose metabolism in rodent models of type 2 diabetes. -- "A Novel Inhibitor of Soluble Epoxide Hydrolase, AR9281, Improves Glucose Homeostasis in Diet-Induced Obese Mice" (Wong, K, Zhang, L-N, Vincelette, J, Chen, D, Mehra, U, Cheng, Y, Gless, R, Anandan, S-K, Webb, H). Data presented in this poster show that in diet-induced obese mice, AR9281 inhibits sEH and improves glucose tolerance in a highly-dose dependent manner. Improvement of glucose tolerance by AR9281 is not observed in sEH knock-out mice indicating that the action of AR9281 is sEH mechanism-based. These positive effects are associated with reductions in plasma insulin, IL-6, an inflammatory molecule elevated in people with type 2 diabetes, and resistin, a hormone that plays a role in predisposing obese individuals to diabetes. -- "Improvement of Glucose Homeostasis by AR9281, a Novel Inhibitor of Soluble Epoxide Hydrolase, in Diet-Induced Obese Mice Does Not Depend on Active Nitric Oxide Synthase" (Vincelette, J, Chen, D, Mehra, U, Cheng, Y, Gless, R, Anandan, S-K, MacIntyre, E and Wang, J). Data presented in this poster show the correlation between treatment with AR9281 and the lowering of the glucose levels after an oral glucose tolerance test and demonstrate that these effects are not inhibited by concurrent treatment with the nitric oxide synthase inhibitor L-NAME (NG-nitro-L-arginine methyl est
'/>"/>

SOURCE Arete Therapeutics Inc. Copyright©2009 PR Newswire. All rights reserved

0 GOOD

Page: 1 2 3 4
Related medicine news :

1. CareTech Receives National Recognition in 2009 Aster Awards for Medical Marketing Excellence
2. CareTech Solutions Launches Robust Service Desk Solution to Support Clinical Applications and Technology within Continuum Health Partners Hospitals
3. CareTech Solutions Caps Banner Year by Signing Pennsylvanias Lehigh Valley Health Network, Tennessees Covenant Health, and Ohios Marietta Memorial Hospital to Provide Web Services
4. Arete Therapeutics Initiates Phase IIa Clinical Trial for AR9281, a Novel s-EH Inhibitor to Treat Type 2 Diabetes
5. EnovateIT Partners with CareTech Solutions to Create a Custom Product for Crittenton Hospital Medical Center, One of the Nation's Most Wired Hospitals
6. CareTech Solutions Named Best in KLAS for Extensive IT Outsourcing Services
7. Nationally Recognized Diabetes Specialist Dr. Steven Edelman to Provide Educational Articles on Diabetes to MyCareTeam's Website Community
8. CareTech Solutions Service Desk Equals Help Desk Plus
9. Arete Therapeutics Appoints Donald Santel to Board of Directors
10. Arete Therapeutics Initiates Phase 1 Clinical Trial For AR9281 as a First-in-Class Antihypertensive Agent
11. CareTech Solutions Executive to Conduct Presentation on Creating a Healthy Revenue Cycle at AHIMA Convention and Exhibit