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Arete Therapeutics Presents Positive Clinical and Preclinical Data for AR9281
Date:6/9/2009

e Epoxide Hydrolase Inhibitor - Efficacy in a DIO Mouse Model plus Pharmacokinetics and Pharmacodynamics in Mice and Men" (Whitcomb, R, Chen, D, Wang, J, Anandan, S-K, Gless, R and Webb, H). This poster describes the direct correlation between the concentration of AR9281 in blood and the activity of its target, sEH, in both mice and humans. The data further demonstrate that AR9281 improves glucose metabolism in rodent models of type 2 diabetes. -- "A Novel Inhibitor of Soluble Epoxide Hydrolase, AR9281, Improves Glucose Homeostasis in Diet-Induced Obese Mice" (Wong, K, Zhang, L-N, Vincelette, J, Chen, D, Mehra, U, Cheng, Y, Gless, R, Anandan, S-K, Webb, H). Data presented in this poster show that in diet-induced obese mice, AR9281 inhibits sEH and improves glucose tolerance in a highly-dose dependent manner. Improvement of glucose tolerance by AR9281 is not observed in sEH knock-out mice indicating that the action of AR9281 is sEH mechanism-based. These positive effects are associated with reductions in plasma insulin, IL-6, an inflammatory molecule elevated in people with type 2 diabetes, and resistin, a hormone that plays a role in predisposing obese individuals to diabetes. -- "Improvement of Glucose Homeostasis by AR9281, a Novel Inhibitor of Soluble Epoxide Hydrolase, in Diet-Induced Obese Mice Does Not Depend on Active Nitric Oxide Synthase" (Vincelette, J, Chen, D, Mehra, U, Cheng, Y, Gless, R, Anandan, S-K, MacIntyre, E and Wang, J). Data presented in this poster show the correlation between treatment with AR9281 and the lowering of the glucose levels after an oral glucose tolerance test and demonstrate that these effects are not inhibited by concurrent treatment with the nitric oxide synthase inhibitor L-NAME (NG-nitro-L-arginine methyl est
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SOURCE Arete Therapeutics Inc.
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