Navigation Links
Arete Therapeutics Initiates Phase IIa Clinical Trial for AR9281, a Novel s-EH Inhibitor to Treat Type 2 Diabetes
Date:2/10/2009

>

"AR9281 operates within the third branch of the arachidonic acid pathway and represents a potentially more specific and selective approach to intervene in metabolic and inflammatory diseases. The first two branches of this critical regulatory pathway have been targeted by several commercially successful marketed anti-inflammatory drugs including Aspirin(R) (acetylsalicylic acid), Motrin(R) (ibuprofen), Singulair(R) (Montelukast) and Celebrex(R) (celecoxib). We designed our Phase IIa trial to further validate the role of s-EH in the pathophysiology of disease and to lay the groundwork for further exploration of s-EH inhibition in treating a broad range of serious diseases including type 2 diabetes, hypertension and inflammatory disorders," commented Randall Whitcomb, M.D., Chief Medical Officer of Arete.

The results of a Phase I clinical program consisting of two double-blind, placebo-controlled studies demonstrated that AR9281 was safe and well tolerated in healthy volunteers. The studies met all safety, tolerability, pharmacokinetic and pharmacodynamic endpoints. In addition, AR9281 has shown favorable results in various published and proprietary in vitro and in vivo assays for potency, selectivity, efficacy, ADME, toxicity and safety.

About Arete Therapeutics Inc.

Arete Therapeutics is a privately-held biotechnology company dedicated to the discovery and development of novel drugs to treat type 2 diabetes, hypertension and inflammatory disorders. It is the world's leading company focused on s-EH, an important enzyme for the metabolism of arachidonic acid that plays an essential role in metabolic, inflammatory and cardiovascular physiology. The Company was founded by Dr. Bruce Hammock, a Professor at the University of California, Davis, who discovered s-EH. The Company has raised a total of over $51 million in Series A financing led by Frazier Healthcare Ventures, Alta Part
'/>"/>

SOURCE Arete Therapeutics Inc.
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine news :

1. CareTech Solutions Executive to Conduct Presentation on Creating a Healthy Revenue Cycle at AHIMA Convention and Exhibit
2. Arete Therapeutics Initiates Phase 1 Clinical Trial For AR9281 as a First-in-Class Antihypertensive Agent
3. Arete Therapeutics Appoints Donald Santel to Board of Directors
4. CareTech Solutions Service Desk Equals Help Desk Plus
5. Nationally Recognized Diabetes Specialist Dr. Steven Edelman to Provide Educational Articles on Diabetes to MyCareTeam's Website Community
6. CareTech Solutions Named Best in KLAS for Extensive IT Outsourcing Services
7. EnovateIT Partners with CareTech Solutions to Create a Custom Product for Crittenton Hospital Medical Center, One of the Nation's Most Wired Hospitals
8. Prime Therapeutics Receives TIPPS Certification
9. Adams Respiratory Therapeutics to Celebrate 10th Anniversary of its Incorporation on September 12
10. Transition Therapeutics Announces Fiscal 2007 Year End Financial Results
11. Lorus Therapeutics announces election of three new Directors and appoints a new Chairman
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/19/2014)... Capital Region Periodontics and Dental ... to announce the latest addition to their treatment ... those needing dental implants. Often referred to as ... the fear factor normally associated with traditional gum ... bleeding make, this procedure a very attractive oral ...
(Date:9/19/2014)... from the wonder material graphene has been used to ... cancer. , The biosensor has been shown to ... tests currently in use, and was able to provide ... possibility of a rapid, point-of-care diagnostic tool for patients. ... in IOP Publishing,s journal 2D Materials . , ...
(Date:9/19/2014)... 19, 2014 The ... Scandinavian style of eating, is making its ... Diet Doc’s medical weight loss ... eating good food which leads to improved ... teaching patients to understand how diet can ...
(Date:9/19/2014)... UT (PRWEB) September 19, 2014 Activz ... Activz Greens Smoothie product, a new whole-food produce ... in Baltimore, MD. Activz Greens Smoothie ... combined in one convenient – and absolutely delicious —Greens ... 18th-20th in Baltimore, MD. , The ...
(Date:9/19/2014)... Centre for Accident Research & Road Safety - Queensland ... in Transport Conference (OSIT) which is being held on ... Blackman, a CARRS-Q road safety researcher, said speed limit ... limits and related traffic controls remained in place at ... If people are asked to slow down at roadwork ...
Breaking Medicine News(10 mins):Health News:Albany, NY Periodontist Reed Ference, DMD, Calms Fears of Patients with Gum Disease by Offering LANAP®, An Advanced, Less Invasive Treatment Solution 2Health News:Albany, NY Periodontist Reed Ference, DMD, Calms Fears of Patients with Gum Disease by Offering LANAP®, An Advanced, Less Invasive Treatment Solution 3Health News:Graphene sensor tracks down cancer biomarkers 2Health News:Diet Doc’s Medical Weight Loss Programs Announce Diet Plans Based on the Same Principles as the New Nordic Diet 2Health News:Diet Doc’s Medical Weight Loss Programs Announce Diet Plans Based on the Same Principles as the New Nordic Diet 3Health News:Diet Doc’s Medical Weight Loss Programs Announce Diet Plans Based on the Same Principles as the New Nordic Diet 4Health News:New Activz Greens Smoothie with 8 Organic Superfoods & More Launched at Natural Products Expo East 2Health News:New Activz Greens Smoothie with 8 Organic Superfoods & More Launched at Natural Products Expo East 3Health News:Don't cry wolf: Drivers fed up with slowing down at inactive roadwork sites 2
... study called 'HERS' conducted by researchers of the University of ... found that Hormone Replacement Therapy (HRT) may be able to ... to develop diabetes as well. ,The study involved some ... or had "impaired fasting glucose" - a condition with ...
... is bad for health is almost an established truth now. ... damage a single serving of pizza could do to our ... group, called the Centre //for Science in the Public Interest ... 15 varieties of pizzas and looked at dietary information provided ...
... recent study by researchers in the Institute of Preventive ... be beneficial in countering dementia and Alzheimer's disease. Scientists, ... monthly were more than two times less likely to ... there may be substances in wine which reduce the ...
... the key to survival on planet earth. Every one of ... happy living. But how many of us know that the ... pressure, continuously over a 24 hour period? According to a ... strained, there may be long-term effects on heart health. ...
... A supplemental new drug application (sNDA) for Valtrex (valacyclovir ... and Drug Administration (FDA) for the treatment of cold ... which also added that this new application for Valtrex// ... to shorten the duration of a cold sore outbreak. ...
... larger portions lead to greater energy intake, meaning, larger the ... Researchers also studied whether the response to portion size differed ... plate. ,The study was carried out with 50 men ... for four weeks. While one group was given a specific ...
Cached Medicine News:Health News:Pizza is bad for health. But, do you know how bad? 2Health News:Unhappy relationships could result in more than just heart breaks! 2
(Date:9/19/2014)... -- Larry J. Merlo , President and CEO of ... the National Press Club in Washington, D.C. ... stop selling tobacco products and its leadership in driving the ... "Dramatic changes in our health care system pose enormous challenges ... said. "CVS Health has a truly unique combination of business ...
(Date:9/19/2014)... -- Alere Inc. (NYSE: ALR ), a global ... in support of President Barack Obama,s Executive ... leader in rapid diagnostics for infectious disease, we commend ... the serious threat of antibiotic resistance. We look forward ... to promote the development of rapid point-of-care tests that, ...
(Date:9/19/2014)... 19, 2014  Lpath, Inc. (NASDAQ: ... therapeutics, announced today that it has entered into ... common stock and 3,605,042 unregistered warrants in a ... one registered share of common stock and one ... common stock will be $3.475.  The warrants have ...
Breaking Medicine Technology:CVS Health CEO to Address National Press Club on Landmark Decision to Quit Tobacco, Leadership in Health Care Innovation 2CVS Health CEO to Address National Press Club on Landmark Decision to Quit Tobacco, Leadership in Health Care Innovation 3Alere Applauds President's Executive Order Combating Antibiotic-Resistant Bacteria 2Lpath, Inc. Announces $12.5 Million Registered Direct Offering 2Lpath, Inc. Announces $12.5 Million Registered Direct Offering 3
...
Listeria Enrichment Broth...
1.7% Tryptone, 0.3% Soytone, 0.5% Sodium Chloride, 0.25% Dextrose, 0.25% Potassium Phosphate....
... accurately and conveniently controls the temperature at your ... temperature levels up to 99 C*, with the ... low as 5 C. The thermoblocks for 0.2 ... and microplates enable a high degree of flexibility ...
Medicine Products: