Navigation Links
Arena Pharmaceuticals Announces Positive Lorcaserin Pivotal Phase 3 Obesity Trial Results: Meets All Primary Efficacy and Safety Endpoints
Date:3/30/2009

d 24 months, rates of valvulopathy for lorcaserin patients crossing over to placebo were 3.6% and 1.9%, respectively.

The FDA has requested that Arena rule out a 1.5-fold or greater risk of valvulopathy with 80% power. Assuming similar results in BLOSSOM (Behavioral modification and LOrcaserin Second Study for Obesity Management), the integrated data set from the two trials will be more than sufficiently large to meet this requirement.

"The echocardiographic safety data is very reassuring," commented Neil J. Weissman, M.D., Co-Principal Investigator, Director, Cardiac Ultrasound and Ultrasound Core Labs, President, MedStar Research Institute, and Professor of Medicine, Georgetown University. "In this double-blind, prospective study, there was no evidence of a difference in the development of valve disease in the large number of patients on lorcaserin versus control for up to two years of continuous use. No prospective valvulopathy trial has ever studied this many patients for this period of time, particularly under such well-controlled circumstances."

Secondary Endpoint Analysis

Treatment with lorcaserin was also associated with statistically significant improvements (ITT-LOCF) in a range of secondary endpoints compared to treatment with placebo, including:

  • Total cholesterol
  • LDL cholesterol
  • Triglycerides
  • Blood pressure

Changes in HDL cholesterol were similar in the two groups. Analysis of the above and additional endpoints, including glucose, insulin and waist circumference, is ongoing and will be announced at a later date.

During Year 2 of the trial, patients continuing on lorcaserin were better able to maintain more of the Week 52 weight loss than Year 1 lorcaserin patients re-randomized to placebo in Year 2.


'/>"/>

SOURCE Arena Pharmaceuticals, Inc.
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7 8 9 10 11

Related medicine news :

1. Arena Pharmaceuticals to Present at the NewsMakers in the Biotech Industry Conference
2. Arena Pharmaceuticals Announces Public Offering of Common Stock
3. Arena Pharmaceuticals to Present at the BIOCOM Investor Conference
4. Arena Pharmaceuticals Announces Pricing of Public Offering of Common Stock
5. Arena Pharmaceuticals to Present at the Merrill Lynch Global Pharmaceutical, Biotechnology and Medical Device Conference
6. Arena Pharmaceuticals Lorcaserin for Obesity Passes Major Safety Milestone
7. Arena Pharmaceuticals to Present at the Morgan Stanley Global Healthcare Unplugged Conference
8. Arena Pharmaceuticals to Report First Quarter 2008 Financial Results and to Host Conference Call and Webcast on Wednesday, May 7, 2008
9. Field Poll: California Nurses Association Most Favorably Viewed Group in Healthcare Arena
10. Childrens Miracle Network and Arena Football League Partner for First Nationwide Celebration Event
11. Arena Pharmaceuticals Announces Third Quarter 2008 Financial Results
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/23/2014)... (PRWEB) August 23, 2014 Summer vacation is ... will be back in session. While shopping for school supplies ... few weeks, Batzner encourages parents and students to also spend ... “Bed bugs are excellent hitchhikers and thrive in heavily populated ... “This makes classrooms and dorms the perfect settings for bed ...
(Date:8/22/2014)... IT manager of Top10BestSEOHosting.com is a web professional who ... recently announced that GoDaddy ( http://www.top10bestseohosting.com/go/GoDaddy.com/ ) is one ... is a popular supplier of cheap web hosting, and ... affordable rates. It offers three Linux shared hosting plans. ... the length of the contract. The longest contract length ...
(Date:8/22/2014)... On Friday, Aug. 22, Liberty University ... Sciences , hosting a ceremony in its courtyard attended ... and public welfare. , The 162-member inaugural class of ... (LUCOM) joined Liberty staff, faculty, and community leaders in ... new medical school. Classes began on Monday, Aug. 4. ...
(Date:8/22/2014)... Today, Zane Benefits, the #1 Online ... Health Plans. , According to Zane Benefits, employers are ... lower the cost of healthcare without reducing coverage for ... however, can be confusing. , The new guide contains ... main types of ABHPs. It also explains the ...
(Date:8/22/2014)... Top 10 Best SEO Hosting (Top10BestSEOHosting.com) has ... highly recommended FatCow ( http://www.top10bestseohosting.com/go/FatCow.com/ ) and BlueHost ... 10 Best SEO Hosting states, “It is hard ... Actually, these companies have outperformed their competitors on ... People can get the best web hosting at ...
Breaking Medicine News(10 mins):Health News:Expert Advice for a Bed Bug-Free School Year 2Health News:Liberty University Dedicates Its New Center for Medical and Health Sciences 2Health News:Liberty University Dedicates Its New Center for Medical and Health Sciences 3Health News:Liberty University Dedicates Its New Center for Medical and Health Sciences 4Health News:FatCow Reviews Released by Top10BestSEOHosting.com 2
... of alcohol abuse costs each Canadian $463 per year. ... abuse in Canada exceed those of cancer. Released today ... Avoidable Cost of Alcohol Abuse in Canada 2002 report estimates ... would result in cost savings of about $1 billion per ...
... much the way alcohol, Alzheimer,s do , , WEDNESDAY, June ... tissue loss in brain regions that help store memory, ... , "Our findings demonstrate that impaired breathing during sleep ... and thinking," principal investigator Ronald Harper, a professor of ...
... IT will Provide Immediate Access to Vital Patient ... ... Jim Traficant,vice president of Harris Corporation,s (NYSE: HRS ) ... Care,Administration (AHCA), and provided a patient,s perspective of healthcare,policy. Traficant projected ...
... of the 1000 Genomes Project announced today that three ... have joined the international effort to build the most ... a tool for medical research. The new participants are: ... Biosystems, an Applera Corp. business, Foster City, Calif.; and ...
... Ill. Primary snoring in children may have an ... obstructive sleep apnea (OSA), according to a research abstract ... 22nd Annual Meeting of the Associated Professional Sleep Societies ... colleagues at the University of Melbourne and Monash University, ...
... cognitive behavioral intervention for insomnia delivered via the Internet ... research abstract that will be presented on Wednesday at ... Professional Sleep Societies (APSS). , The study, authored by ... on 44 participants (mostly female) with an average age ...
Cached Medicine News:Health News:Save $1 billion and 800 lives 2Health News:Save $1 billion and 800 lives 3Health News:Sleep Apnea Linked to Memory Loss 2Health News:Harris Corporation's Jim Traficant Addresses Florida Agency for Health Care Administration 2Health News:3 sequencing companies join 1000 Genomes Project 2Health News:3 sequencing companies join 1000 Genomes Project 3Health News:3 sequencing companies join 1000 Genomes Project 4Health News:3 sequencing companies join 1000 Genomes Project 5Health News:Primary snoring in children impacts cardiovascular functioning 2Health News:Primary snoring in children impacts cardiovascular functioning 3Health News:A self-help program delivered online can improve insomnia in adults 2
(Date:8/21/2014)... , Aug. 21, 2014  Vermillion, Inc. (NASDAQ: ... on gynecologic cancers and women,s health, has appointed ... and Managed Markets. Ms. Bauzon has a ... expanding payer coverage for laboratory services companies. She has ... with PerkinElmer, Inc., where she held the position of ...
(Date:8/21/2014)... 2014  eRelevance Corporation ( www.erelevancecorp.com ), a ... it has completed integration with Nextech, a popular ... and Dermatology practices. "Integration allows our ... practices using Nextech," stated Bob Fabbio , ... from the EMR we are able to automatically ...
(Date:8/21/2014)... , Aug. 21, 2014  Publicis Groupe ... Hartley , Managing Partner and Healthcare Industry Group Leader, ... 100, which recognizes the most inspiring people in the ... leaders in research and development, marketing, technology, creativity, strategy ... in 2006 as a partner in its leading Rosetta ...
Breaking Medicine Technology:Vermillion Appoints Holly B. Bauzon as VP of Sales and Managed Markets 2eRelevance Corporation Integrates with Nextech Electronic Medical Records 2Shannon Hartley Shines in PharmaVOICE 100 2
... 18, 2012  Sotera Wireless, Inc. announced that it has ... Drug Administration (FDA) for the ViSi Mobile™   System, ... in hospitals. The clearance represents a major milestone in ... system, particularly for ambulatory hospital patients. "Continuous ...
... UBM Live has revealed further details of the ... Southeast Asia (SEA) 2012. Set to debut from 10-12 May ... is the first trade show and exhibition of its kind ... ASEAN region. CPhI SEA will provide a ...
Cached Medicine Technology:Sotera Wireless Reports FDA Clearance of ViSi Mobile™ System 2Leading Pharma Ingredients Event Debuts in Growing ASEAN Market 2Leading Pharma Ingredients Event Debuts in Growing ASEAN Market 3
Katena ophthalmic burr for polishing pterygiums, includes one round diamond burr and has an storage case....
Illuminated Trial Lens Set is an attractive set of trial lenses worked to a high standard of accuracy....
Trial Lens Sets....
... is the first ... to offer two kinds ... and taurine. Cleans, rinses, ... and conditions any soft ...
Medicine Products: