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Arena Pharmaceuticals Announces Lorcaserin Phase 2b Clinical Trial Results Published in Obesity
Date:12/8/2008

ults were observed by intent to treat, last observation carried forward (ITT-LOCF) analysis. A statistically significant percentage of lorcaserin patients completing the study lost greater than or equal to 5% of their weight from baseline: 12.8%, 19.5% and 31.2% in the 10 mg, 15 mg and 20 mg groups, respectively, compared to 2.3% of patients on placebo. The response rate to lorcaserin was high, with more than 90% of patients achieving some degree of weight loss at the 20 mg dose.

Total cholesterol and waist circumference, both correlates of cardiovascular risk, were significantly decreased by the two highest lorcaserin doses in this relatively short trial. Improvements in other secondary endpoints were also achieved, including fasting blood sugar at the 20 mg dose.

Lorcaserin was generally well tolerated at all doses in the study. The most common side effects were mild to moderate and transient headache, nausea and dizziness. Importantly, lorcaserin did not increase blood pressure or heart rate at any dose. Echocardiograms conducted at screening and completion of the study demonstrated no apparent drug-related effects on heart valves or pulmonary arterial pressure.

About Lorcaserin

Lorcaserin, Arena's internally discovered oral drug candidate for the treatment of obesity, is in an ongoing Phase 3 program. The compound is the first in a new class of obesity drug candidates stimulating the 5-HT2C serotonin receptor, which is located in the hypothalamus, an area of the brain associated with regulation of food intake and metabolism.

About Obesity

Obesity affects tens of millions of people in the United States and poses a serious long-term threat to their health and welfare. The number of overweight and obese people has substantially increased over the past several decades. Approximately two-thirds of all adults in the United States are obese or overweight, and medi
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SOURCE Arena Pharmaceuticals, Inc.
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