Navigation Links
Area Around Breast Tumor May Predict Cancer's Spread
Date:12/19/2007

Mutations in tumor-suppressing gene could point to lymph node involvement, study suggests

WEDNESDAY, Dec. 19 (HealthDay News) -- Supposedly "innocent" cells in the area surrounding cancerous tumors in the breast are definitely not always innocent and can predict whether or not the cancer spreads to the lymph nodes, new research suggests.

The finding of alterations in the tumor-suppressing p53 gene in the stroma -- the region surrounding the tumor -- have future implications, the researchers said.

"The stroma looks innocent under the microscope, but there's an evil seed in innocent soil," said study senior author Dr. Charis Eng, chair of the Cleveland Clinic Genomic Medicine Institute in Ohio.

"This could be a new type of [cancer] biomarker, p53 in the stroma," she added.

In addition, the findings may one day eliminate the need to remove and dissect the lymph nodes which, as Eng points out, is a "nuisance" to patients.

Even further down the line, the stroma might provide a new target for drug therapies.

"It's a significant study," said Steve A. Maxwell, an associate professor of molecular and cellular medicine at Texas A&M Health Science Center College of Medicine, in College Station. "Treatments targeting p53 in the stroma might lead to suppression of spread [of the cancer] or to prevention of recurrence. I don't see it as a cure, but it could contain future spread."

Further research is needed before any of these scenarios become reality, the researchers said.

The findings are published in the Dec. 20 issue of the New England Journal of Medicine.

"Communication" between a tumor and the stroma is increasingly a subject of research.

So is p53, a much-studied oncogene. P53 is involved in repairing DNA damage and other functions which prevent cells from turning malignant. This gene is mutated in 20 percent to 50 percent of breast ca
'/>"/>

Copyright©2007 ScoutNews,LLC.
All rights reserved  

Page: 1 2 3

Related medicine news :

1. Bicyclist to Stop in DC during 9,000 Mile Lap Around the U.S.
2. Health Organizations Join Forces Around Quit-Smoking Help
3. Bicyclist Will Conclude 9,000 Mile Lap Around the U.S. on Sunday in New York City
4. Children Around the Globe Walk Toward a Lifetime of Healthy Habits
5. Negative Publicity Around PFFS Sales Practices Not Getting Through to Seniors
6. Galderma Associates Itself to Cartiers Womens Initiative Awards to Recognize Female Entrepreneurs From Around the Globe
7. Take a Culinary Trip Around the World for a Good Cause: March of Dimes
8. Safe Crossing Week 2007 Teaches Kids How to Behave Safely Around Trains
9. New Poll Shows Catholics Around the World Believe Good Catholics Can Use Condoms
10. Researchers From Around the World Gather to Discuss Triple Negative Breast Cancer
11. Survival differences by race most apparent in advanced stages of breast cancer
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Area Around Breast Tumor May Predict Cancer's Spread
(Date:3/3/2015)... OH (PRWEB) March 03, 2015 ... to better predict antidepressant treatment outcomes for patients ... resources, than any of the individual genes that ... by investigators from the Mayo Clinic and Assurex ... i. , The proprietary technology of the ...
(Date:3/3/2015)... The number of couples experiencing infertility ... 15%. This increases to 50% by the time a ... Yuzpe AA, et al. Estimating the prevalence of infertility ... Hitkari, a reproductive endocrinologist and co-director at Olive Fertility ... clinical director and founder of Acubalance Wellness Centre will ...
(Date:3/3/2015)... With a grant of more than $4.5 ... has been named a national coordinating center by the ... for Health: Improving Community Health Through Innovations in Financing ... health and reduce disparities through innovations in collaboration and ... of the center and up to 10 communities over ...
(Date:3/3/2015)... 03, 2015 The Calistoga Chamber of Commerce ... All Weekends,” taking place Friday, March 27, through Sunday, March ... Muddy 5K fun run, restaurant and bar crawl, lodging and ... to women, ages 14 and older. , A variety of ... in on the action by offering Mudder of All Weekends ...
(Date:3/3/2015)... (PRWEB) March 03, 2015 -- vRad ( ... radiology practice, today announced that Arlene Sussman, MD, a ... host a live webinar to explore how telemedicine best ... breast imaging services for women virtually anywhere. Click ... Imaging Service Line” on March 4, 2015 at 1:00 ...
Breaking Medicine News(10 mins):Health News:GeneSight Multi-Gene Combinatorial Pharmacogenomic (CPGx™) Test is More Predictive of Antidepressant Response than Single Gene Tests 2Health News:GeneSight Multi-Gene Combinatorial Pharmacogenomic (CPGx™) Test is More Predictive of Antidepressant Response than Single Gene Tests 3Health News:GeneSight Multi-Gene Combinatorial Pharmacogenomic (CPGx™) Test is More Predictive of Antidepressant Response than Single Gene Tests 4Health News:GeneSight Multi-Gene Combinatorial Pharmacogenomic (CPGx™) Test is More Predictive of Antidepressant Response than Single Gene Tests 5Health News:GeneSight Multi-Gene Combinatorial Pharmacogenomic (CPGx™) Test is More Predictive of Antidepressant Response than Single Gene Tests 6Health News:New Treatment Approach Helps Boost Chance of Pregnancy; Information Seminar at Olive Fertility Center 2Health News:New Treatment Approach Helps Boost Chance of Pregnancy; Information Seminar at Olive Fertility Center 3Health News:New Treatment Approach Helps Boost Chance of Pregnancy; Information Seminar at Olive Fertility Center 4Health News:Robert Wood Johnson Foundation Names Georgia Health Policy Center National Center for Bridging for Health Initiative 2Health News:Visit Calistoga Hosts Mudder of All Weekends Girlfriend Getaway Event 2Health News:Visit Calistoga Hosts Mudder of All Weekends Girlfriend Getaway Event 3Health News:Latest vRad Webinar: Building World-Class Breast Imaging Services Virtually Anywhere with Telemedicine Best Practices 2Health News:Latest vRad Webinar: Building World-Class Breast Imaging Services Virtually Anywhere with Telemedicine Best Practices 3Health News:Latest vRad Webinar: Building World-Class Breast Imaging Services Virtually Anywhere with Telemedicine Best Practices 4
... , WASHINGTON, Sept. 9 Former presidential ... care address said Tuesday that he would be listening for ... willing to make to show that his promises of bipartisan ... The chairman of the Campaign for Working Families made the ...
... , , , BOSTON and ... its causes, potential cures, current treatments and strategies for living well ... Macular Degeneration Symposium on September 17. A free public educational program, ... the Barnstable Senior Center, 825 Falmouth Road (Rt. 28) in Hyannis. ...
... FLEMINGTON, N.J., Sept. 9 HCD Research announced ... Barack Obama,s speech on health care reform tonight to obtain ... care reform. , , (Logo: ... HCD Research will conduct the study using its MediaCurves.com(R) website ...
... , , LAKE MARY, ... nation,s largest independent specialty pharmacy providers, was again chosen as ... is the fifth consecutive year that Axium has received this ... Business Journal recognizes the top 100 privately held companies in ...
... , , PRINCETON, N.J., Sept. 9 ... ) today announced the opening of new clinical development offices in Sao ... global footprint with a comprehensive range of services across Latin America. Earlier ... These new sites will support staff in these countries, Central America, and ...
... pandemic may have antiviral properties, scientists say, , WEDNESDAY, Sept. ... sap has components that show great efficacy in killing off ... plant, Ferula assa-foetida , grows throughout Iran, Afghanistan and ... due to its ill-smelling sap. But the researchers note that ...
Cached Medicine News:Health News:Bauer Calls for News of Concrete Compromise from President Obama 2Health News:First Cape Cod Macular Degeneration Symposium To Be Held on September 17 2Health News:First Cape Cod Macular Degeneration Symposium To Be Held on September 17 3Health News:Research Firm will Obtain Americans' Reactions to the President's Speech on Health Care Reform 2Health News:Axium Healthcare Pharmacy, Inc. Has Been Chosen as One of 'Central Florida's Golden 100 Companies' for the Fifth Year in a Row 2Health News:Covance Opens New Clinical Development Offices in Brazil and Mexico 2Health News:Covance Opens New Clinical Development Offices in Brazil and Mexico 3
(Date:3/3/2015)... YORK , March 3, 2015  PlasmaTech Biopharmaceuticals, ... advancing protein biologic therapies and oncology supportive care products, ... Annual ROTH Capital Partners Conference which is being ... Niguel in Dana Point, California.  PlasmaTech,s ... to present a corporate update on Wednesday, March 11, ...
(Date:3/3/2015)... DENVER , March 3, 2015  Tru-D ... at the Association for Perioperative Registered Nurses, Surgical ... Colorado , during Patient Safety Awareness Week ... with resources for safe clinical practice and professional ...   Photo - http://photos.prnewswire.com/prnh/20150302/178998LOGO   ...
(Date:3/3/2015)...  HeartIT is pleased to officially announce the ... Solution in the market which allows Viewing, Analysis, ... Precession™ combines zero footprint web technology along with ... This provides CMR professionals with a single solution ... a successful CMR program. Precession™ embraces ...
Breaking Medicine Technology:PlasmaTech Biopharmaceuticals To Present at 27th Annual ROTH Capital Partners Conference 2Tru-D SmartUVC to Exhibit Most Effective UV Disinfection Robot at AORN Surgical Conference and Expo 2015 2Tru-D SmartUVC to Exhibit Most Effective UV Disinfection Robot at AORN Surgical Conference and Expo 2015 3Precession Advances Medical Imaging by Delivering a Complete Cardiac Magnetic Resonance Platform in a Web Browser 2
... July 30 Zargis Medical Corp., a majority-owned subsidiary of ... Care System (VAPAHCS), a northern California based hospital group that ... hospitals, recently purchased 15 Zargis Cardioscan systems. , ... The VA Palo Alto Health Care System (VAPAHCS) consists ...
... 29 Sequenom, Inc. (Nasdaq: SQNM ), will report second quarter 2010 financial results after market close ... 1:30 pm Pacific Time ( 4:30 pm Eastern Time ) on the same day. , ... Information: , , , ... International callers: +1- 857-350-1603 , , ...
Cached Medicine Technology:Veterans Administration Health Care System Purchases 15 Zargis Cardioscan Systems 2Veterans Administration Health Care System Purchases 15 Zargis Cardioscan Systems 3Sequenom Announces Date of Second Quarter 2010 Financial Results and Conference Call 2
... Reference Series 2000 Pipette is a synonym ... compact and robust design, and superior operating ... to operate the measuring stroke and blow-out ... features:Eppendorf "pipette/tip" system ensures utmost accuracy and ...
... Pipette is a synonym for pipetting accuracy, ... design, and superior operating comfort. Its single, ... measuring stroke and blow-out as well as ... ensures utmost accuracy and precision. Ejection sleeve ...
... Finnpipette Focus from Thermo Labsystems ... ergonomics with uncompromising performance. ... offers a custom fit for ... shorter tip cones allow easier ...
... Testing System is the smallest blood glucose testing ... when you need it in your backpack ... simply in your purse or pocket.* Its small ... go. And, because it's so convenient it's easier ...
Medicine Products: