Navigation Links
Area Around Breast Tumor May Predict Cancer's Spread
Date:12/19/2007

Mutations in tumor-suppressing gene could point to lymph node involvement, study suggests

WEDNESDAY, Dec. 19 (HealthDay News) -- Supposedly "innocent" cells in the area surrounding cancerous tumors in the breast are definitely not always innocent and can predict whether or not the cancer spreads to the lymph nodes, new research suggests.

The finding of alterations in the tumor-suppressing p53 gene in the stroma -- the region surrounding the tumor -- have future implications, the researchers said.

"The stroma looks innocent under the microscope, but there's an evil seed in innocent soil," said study senior author Dr. Charis Eng, chair of the Cleveland Clinic Genomic Medicine Institute in Ohio.

"This could be a new type of [cancer] biomarker, p53 in the stroma," she added.

In addition, the findings may one day eliminate the need to remove and dissect the lymph nodes which, as Eng points out, is a "nuisance" to patients.

Even further down the line, the stroma might provide a new target for drug therapies.

"It's a significant study," said Steve A. Maxwell, an associate professor of molecular and cellular medicine at Texas A&M Health Science Center College of Medicine, in College Station. "Treatments targeting p53 in the stroma might lead to suppression of spread [of the cancer] or to prevention of recurrence. I don't see it as a cure, but it could contain future spread."

Further research is needed before any of these scenarios become reality, the researchers said.

The findings are published in the Dec. 20 issue of the New England Journal of Medicine.

"Communication" between a tumor and the stroma is increasingly a subject of research.

So is p53, a much-studied oncogene. P53 is involved in repairing DNA damage and other functions which prevent cells from turning malignant. This gene is mutated in 20 percent to 50 percent of breast cancers.

In 1999, Eng's group looked at seemingly harmless stromal cells and found that they had cancer-related mutations in the p53 gene.

For this study, the group looked at whether genetic alterations in the stroma had any impact on clinical outcomes, and if they could predict the spread of the cancer.

To this end, they analyzed tissue samples from 218 breast cancer patients: 43 with hereditary breast cancer and 175 with sporadic breast cancer.

A technique called laser-capture microdissection was used to take individual breast cancer cells and surrounding stromal cells.

Mutations in p53, in the stroma but not in the cancer, increased the chances that the cancer would spread to the lymph nodes, indicating a worse outcome for these patients.

But even when the p53 alteration was not present, changes in five other markers resulted in the same outcome.

In other words, changes in the microenvironment surrounding a tumor can impact how the cancer spreads, the research suggests.

A second study in the same issue of the journal found that mutations in the same p53 gene were associated with shorter survival after surgery in patients with squamous-cell carcinoma of the head and neck.

This type of cancer is one of the most common cancers in the world; more than 45,000 new cases are expected to be diagnosed in the United States in 2007.

P53 mutations in general and a specific p53 mutation were associated with poorer survival, reported a team led by Dr. Wayne Koch, of Johns Hopkins University, Baltimore.

More information

There's more on the p53 gene at the U.S. National Library of Medicine.



SOURCES: Charis Eng, M.D., Ph.D., chair, Cleveland Clinic Genomic Medicine Institute, Ohio; Steve A. Maxwell, Ph.D., associate professor, molecular and cellular medicine, Texas A&M Health Science Center College of Medicine, College Station; Dec. 20, 2007, New England Journal of Medicine


'/>"/>
Copyright©2007 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Bicyclist to Stop in DC during 9,000 Mile Lap Around the U.S.
2. Health Organizations Join Forces Around Quit-Smoking Help
3. Bicyclist Will Conclude 9,000 Mile Lap Around the U.S. on Sunday in New York City
4. Children Around the Globe Walk Toward a Lifetime of Healthy Habits
5. Negative Publicity Around PFFS Sales Practices Not Getting Through to Seniors
6. Galderma Associates Itself to Cartiers Womens Initiative Awards to Recognize Female Entrepreneurs From Around the Globe
7. Take a Culinary Trip Around the World for a Good Cause: March of Dimes
8. Safe Crossing Week 2007 Teaches Kids How to Behave Safely Around Trains
9. New Poll Shows Catholics Around the World Believe Good Catholics Can Use Condoms
10. Researchers From Around the World Gather to Discuss Triple Negative Breast Cancer
11. Survival differences by race most apparent in advanced stages of breast cancer
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Area Around Breast Tumor May Predict Cancer's Spread
(Date:6/27/2016)... ... June 27, 2016 , ... TherapySites, ... its affiliation with Tennessee Counseling Association. This new relationship allows TherapySites ... Tennessee Counseling Association, adding exclusive benefits and promotional offers. , "TCA is extremely ...
(Date:6/26/2016)... ... ... Quality metrics are proliferating in cancer care, and are derived from many of ... beholder, according to experts who offered insights and commentary in the current issue of ... full issue, click here . , For the American Society of Clinical Oncology ...
(Date:6/26/2016)... ... ... Brent Kasmer, a legally blind and certified personal trainer is helping to develop a weight ... app plans to fix the two major problems leading the fitness industry today:, ... program , They don’t eliminate all the reasons people quit their exercise program ...
(Date:6/25/2016)... ... ... Bruton Memorial Library on June 21 due to a possible lice infestation, as reported by ... lice: the parasite’s ability to live away from a human host, and to infest common ... the event that lice have simply gotten out of control. , As lice are a ...
(Date:6/25/2016)... Oklahoma City, Oklahoma (PRWEB) , ... June 25, ... ... to helping both athletes and non-athletes recover from injury. Recently, he has implemented ... for the Oklahoma City area —Johnson is one of the first doctors to ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... June 24, 2016  Arkis BioSciences, a leading ... and more durable cerebrospinal fluid treatments, today announced ... Series-A funding is led by Innova Memphis, followed ... other private investors.  Arkis, new financing will accelerate ... the market release of its in-licensed Endexo® technology. ...
(Date:6/23/2016)... BEVERLY HILLS, Calif. , June 23, 2016 ... faced the many challenges of the current process. Many of ... option because of the technical difficulties and high laboratory costs ... would have to offer it at such a high cost ... to afford it. Dr. Parsa Zadeh , ...
(Date:6/23/2016)... Roche (SIX: RO, ROG; OTCQX: RHHBY) announced that it ... (procalcitonin) assay as a dedicated testing solution for people ... Roche is the first IVD company in the U.S ... assessment and management. PCT is a sepsis-specific ... blood can aid clinicians in assessing the risk of ...
Breaking Medicine Technology: