Navigation Links
Area Around Breast Tumor May Predict Cancer's Spread
Date:12/19/2007

Mutations in tumor-suppressing gene could point to lymph node involvement, study suggests

WEDNESDAY, Dec. 19 (HealthDay News) -- Supposedly "innocent" cells in the area surrounding cancerous tumors in the breast are definitely not always innocent and can predict whether or not the cancer spreads to the lymph nodes, new research suggests.

The finding of alterations in the tumor-suppressing p53 gene in the stroma -- the region surrounding the tumor -- have future implications, the researchers said.

"The stroma looks innocent under the microscope, but there's an evil seed in innocent soil," said study senior author Dr. Charis Eng, chair of the Cleveland Clinic Genomic Medicine Institute in Ohio.

"This could be a new type of [cancer] biomarker, p53 in the stroma," she added.

In addition, the findings may one day eliminate the need to remove and dissect the lymph nodes which, as Eng points out, is a "nuisance" to patients.

Even further down the line, the stroma might provide a new target for drug therapies.

"It's a significant study," said Steve A. Maxwell, an associate professor of molecular and cellular medicine at Texas A&M Health Science Center College of Medicine, in College Station. "Treatments targeting p53 in the stroma might lead to suppression of spread [of the cancer] or to prevention of recurrence. I don't see it as a cure, but it could contain future spread."

Further research is needed before any of these scenarios become reality, the researchers said.

The findings are published in the Dec. 20 issue of the New England Journal of Medicine.

"Communication" between a tumor and the stroma is increasingly a subject of research.

So is p53, a much-studied oncogene. P53 is involved in repairing DNA damage and other functions which prevent cells from turning malignant. This gene is mutated in 20 percent to 50 percent of breast ca
'/>"/>

Copyright©2007 ScoutNews,LLC.
All rights reserved  

Page: 1 2 3

Related medicine news :

1. Bicyclist to Stop in DC during 9,000 Mile Lap Around the U.S.
2. Health Organizations Join Forces Around Quit-Smoking Help
3. Bicyclist Will Conclude 9,000 Mile Lap Around the U.S. on Sunday in New York City
4. Children Around the Globe Walk Toward a Lifetime of Healthy Habits
5. Negative Publicity Around PFFS Sales Practices Not Getting Through to Seniors
6. Galderma Associates Itself to Cartiers Womens Initiative Awards to Recognize Female Entrepreneurs From Around the Globe
7. Take a Culinary Trip Around the World for a Good Cause: March of Dimes
8. Safe Crossing Week 2007 Teaches Kids How to Behave Safely Around Trains
9. New Poll Shows Catholics Around the World Believe Good Catholics Can Use Condoms
10. Researchers From Around the World Gather to Discuss Triple Negative Breast Cancer
11. Survival differences by race most apparent in advanced stages of breast cancer
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Area Around Breast Tumor May Predict Cancer's Spread
(Date:3/27/2015)... 27, 2015 Ticket Down is a reputable source ... 2015. After a phenomenal and highly successful live tour last ... going out on tour again in 2015 and they will be ... on April 29th in New York City at the cozy Beacon ... Theatre on May 10th. , Fans of the hit show can ...
(Date:3/27/2015)... 27, 2015 According to a recently ... the plate and screw market in Europe is in ... plate and screw segment. Price decreases are being seen ... almost 50% of the total European trauma device market, ... total market value, year after year. , “Such ...
(Date:3/27/2015)... March 27, 2015 The report “CountryFocus: ... essential source of information on and analysis of the ... population of the US in 2013 amounted to 316.1 ... (CAGR) of 0.8% from 2008. The country’s increasingly elderly ... diseases will help to boost the growth of the ...
(Date:3/27/2015)... Diego, CA (PRWEB) March 27, 2015 ... launch its Protect Our Children (POC) NOW! vitamin D ... the Medical University of South Carolina (MUSC), and will ... will be available at no cost to a minimum ... gestation who live within these two service areas. The ...
(Date:3/27/2015)... 27, 2015 Trail mix is the perfect, ... on weekend hikes and during the game! It’s portable, lightweight ... is proud to introduce a new line of specialty trail ... rich and flavorful selections packed with nutritious, 100% all natural ... and grains that add protein and fiber to your diet ...
Breaking Medicine News(10 mins):Health News:Nashville Live in Concert Tickets in New York, Boston, Washington, DC, Chicago, Minneapolis, San Francisco, Los Angeles and Phoenix Now On Sale at TicketDown.com 2Health News:Titanium Trauma Treatment Devices in Europe Becoming More Affordable, Decreasing Market Value: Group Purchasing Further Eroding Selling Prices 2Health News:Titanium Trauma Treatment Devices in Europe Becoming More Affordable, Decreasing Market Value: Group Purchasing Further Eroding Selling Prices 3Health News:US Pharmaceutical Market worth $548.4 billion by 2020 Says a New Report Available at RnRMarketResearch.com 2Health News:US Pharmaceutical Market worth $548.4 billion by 2020 Says a New Report Available at RnRMarketResearch.com 3Health News:US Pharmaceutical Market worth $548.4 billion by 2020 Says a New Report Available at RnRMarketResearch.com 4Health News:GrassrootsHealth Moves Vitamin D into Practice with Pregnant Women 2Health News:GrassrootsHealth Moves Vitamin D into Practice with Pregnant Women 3Health News:GrassrootsHealth Moves Vitamin D into Practice with Pregnant Women 4Health News:Aurora Product, Inc. Introduces New Line of Specialty Trail Mixes 2
... study in the September 27 issue of JAMA says that ... the risk of reinfections.// Trachoma is an infectious disease where ... reported that 15 percent of all blindness was caused by ... cataract., ,At that time, the WHO estimated that 146 ...
... a condom that plays music during sex, Korrespondent magazine ... control device as a novelty, and as an aid ... miniature loudspeaker and motion sensor implanted in the condom's ... sex. ,The condom's main limitation is primitive ...
... for infecting cornea cells that may also explain how it ... at the University of Illinois at Chicago College of Medicine. ... of the Journal of Cell Biology. ,Both strains ... cold sores on the mouth, and HSV-2, genital herpes -- ...
... the Johns Hopkins University and other institutions have developed ... Lynch syndrome// , which predisposes families to develop colorectal ... individual’s detailed family history of colorectal and endometrial cancer, ... themselves—in the form of tumors. It can assess a ...
... ?4 million cash boost to fight the spread of the deadly ... towards stemming Scotland's high rates of the infection as well as ... been estimated that about 20,000 people have been infected with Hepatitis ... among Scotland's drug users - in NHS Greater Glasgow and Clyde. ...
... proposed by the FDA for the anti-angiogenic colorectal-cancer drug ... posterior leukoencephalopathy syndrome in its warning.// ,Genentech, ... has been reported or confirmed in less than 0.1% ... ,The Adverse Reactions and Dosage and Administration ...
Cached Medicine News:Health News:Blindness And Trachoma 2Health News:Herpes Infects Cornea, Evades Immune Cells 2Health News:Model Predicts Colon Cancer Inheritable Genetic Defects 2Health News:Scotland’s Fight against Hepatitis C Boosted by ? 2Health News:Warning on Avastin Updated 2
(Date:3/27/2015)... -- Levi & Korsinsky announces it has commenced an ... concerning possible violations of federal securities laws. The investigation ... with its study of the drug OHR-102. To obtain ... Joseph E. Levi, Esq. either via email ... 363-7500, toll-free: (877) 363-5972. Levi & Korsinsky ...
(Date:3/27/2015)... , March 27, 2015  Holographic Optical Technologies of ... field of holographic medical imaging, is entering the world ... campaign. Launching on April 20 th , 2015, the ... Pro. The 8-inch and 22-inch displays will allow consumers ... the first time. In addition to the two displays, ...
(Date:3/27/2015)... -- A new report from Kalorama Information says that other ... Chile , Colombia and ... firms.  The healthcare research firm said that while ... Latin American continent with a population of over 200 million ... the country,s regional economic clout does not necessarily ensure its ...
Breaking Medicine Technology:Holographic Optical Technologies brings cutting-edge holograms to consumer market through upcoming Kickstarter campaign 2Holographic Optical Technologies brings cutting-edge holograms to consumer market through upcoming Kickstarter campaign 3Kalorama: Beyond Brazil, Latin American IVD Market Grows 2Kalorama: Beyond Brazil, Latin American IVD Market Grows 3Kalorama: Beyond Brazil, Latin American IVD Market Grows 4
... Calif., Feb. 2 InterMune, Inc.,(Nasdaq: ITMN ... its Phase 3,CAPACITY program of pirfenidone in idiopathic pulmonary ... InterMune will conduct a conference,call and webcast, with ... at 8:00 a.m. EST (5:00 a.m. PST) on Tuesday,February ...
... ability of human-animal hybrids to generate stem cells ... (OTC Pink Sheets: ACTC) and its collaborators reported today ... extensively reprogram adult human cells. The research, which appears ... and Stem Cells (Editor-in-Chief: Sir Ian Wilmut; published ...
Cached Medicine Technology:InterMune to Announce Results of Phase 3 CAPACITY Program of Pirfenidone in IPF Tomorrow, February 3 2Cloned Human Embryos Successfully Reprogrammed Using Human - But Not Animal - Eggs 2Cloned Human Embryos Successfully Reprogrammed Using Human - But Not Animal - Eggs 3Cloned Human Embryos Successfully Reprogrammed Using Human - But Not Animal - Eggs 4Cloned Human Embryos Successfully Reprogrammed Using Human - But Not Animal - Eggs 5
Lytec Medical 2004 practice management software is designed to help you more effectively manage your accounts receivable as well as track authorizations and inventory. Lytec Medical XE provides outst...
PremierEdge™ Stab Knives - 30°....
DCR Set, Angled....
... Leica CM3050 S Cryostat Family ... excellent safety standards for practically ... The Leica CM3050 S is ... all cryosectioning research applications and ...
Medicine Products: