Navigation Links
Are there gender differences in anti-HIV drug efficacy?
Date:8/9/2012

New Rochelle, NY, August 9, 2012Women comprise nearly half of the HIV-infected population worldwide, but these 15.5 million women tend to be under-represented in clinical trials of anti-HIV drug therapies. The U.S. Food and Drug Administration (FDA) has created a database from 40 clinical studies to assess gender differences in the efficacy of antiretroviral treatments. The results of this study are presented in an article in AIDS Patient Care and STDs, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers. The article is available free on the AIDS Patient Care and STDs website at http://www.liebertpub.com/apc.

Guoxing Soon and coauthors from the FDA and University of Texas Southwestern Medical Center, Dallas, TX, found that women represented only about 20% of the subjects in randomized clinical trials submitted to the FDA between 2000 and 2008. The article "Meta-Analysis of Gender Differences in Efficacy Outcomes for HIV-Positive Subjects in Randomized Controlled Clinical Trials of Antiretroviral Therapy (2000-2008)" compares the effectiveness of anti-HIV drug regimens reported for women versus men overall and among various subgroups.

The authors found no statistically or clinical significant differences between women and men in outcomes with regard to viral load after 48 weeks. However, they did report significant gender differences favoring males based on subgroup analyses.

"This is a critical area of research in terms of developing new HIV therapies," says Editor-in-Chief Jeffrey Laurence, MD, Director of the Laboratory for AIDS Virus Research at Weill Medical College of Cornell University, New York, NY. "Mounting evidence indicates that metabolism of certain drugs varies in men vs. women, and side effects that interfere with adherence to these medications may also be manifest differently."


'/>"/>
Contact: Vicki Cohn
vcohn@liebertpub.com
914-740-2100
Mary Ann Liebert, Inc./Genetic Engineering News
Source:Eurekalert  

Page: 1

Related medicine news :

1. New findings by GW researcher break tanning misconceptions: There is no such thing as a safe tan
2. Dr. Carol Francis Radio Talk Show Discusses Sexual Abuse as Related to "Coach" Jerry Sandusky; Interview With Abuse Survivor Teresa Joyce, Author of "There's A Fine Line"
3. Love Knows No Gender Difference
4. Report Calls for Counseling Guidelines for Treating Transgender People
5. APA task force recommends treatment guidelines and position statements on transgender persons
6. Health-care law gender gap
7. Mayo Clinic study links healthy muscle mass to healthy bones, finds differences by gender
8. Racial differences in diabetes diagnostic thresholds
9. Study finds significant skull differences between closely linked groups
10. Hair samples from infants show exposure to anti-HIV drugs in the womb and during breast-feeding
11. Taking Anti-HIV Meds Prior to Exposure May Help Prevent Infection
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Are there gender differences in anti-HIV drug efficacy?
(Date:5/22/2017)... ST. PAUL, Minn. (PRWEB) , ... May 22, 2017 , ... ... one young man’s experience learning to live with Bipolar 1. Donald Rodriguez takes readers ... icy mountain in Alaska in the dead of winter and to a dark place ...
(Date:5/21/2017)... , ... May 19, 2017 , ... Chris Cornell, 52, was found dead on the ... one of the most respected lead singers in the rock industry would take his own ... mental illness. FindaTopDoc investigates how mental illness played a role in the death of ...
(Date:5/21/2017)... ... May 21, 2017 , ... ... together a cross-disciplinary group of scholars, policymakers, and activists wanting to address equity ... Equity is the third book from a recent series of from this ...
(Date:5/19/2017)... Delaware (PRWEB) , ... May 19, 2017 , ... In ... home, PlushBeds , a luxury online mattress company that specializes in natural and ... (the nation’s leading grassroots autism organization) for every unique share their recent viral ...
(Date:5/19/2017)... ... May 19, 2017 , ... The Hill Agencies, a family managed ... throughout the California Central Valley, is announcing a joint charity initiative with the Boys ... a local kid’s camp event. , The Boys and Girls Club of Kern County ...
Breaking Medicine News(10 mins):
(Date:5/10/2017)... 10, 2017 Hologic, Inc. (Nasdaq: ... the fiscal second quarter ended April 1, 2017 . ... increased 666.7% compared to the prior year period as ... a significant gain, while non-GAAP diluted EPS of $0.50 ... 3.8% in constant currency terms.  Excluding the effects of ...
(Date:5/9/2017)... May 9, 2017 Zimmer Biomet Holdings, Inc. ... healthcare, today announced it has earned a spot on ... list. The Company was ranked among 500 U.S. employers ... and Healthcare Equipment and Services. The annual ... an anonymous, independent survey of over 30,000 employees across ...
(Date:5/8/2017)... , May 8, 2017  Diplomat Pharmacy, Inc. ... Communications, Inc. ("WRB"), a health care service center ... WRB specializes in relationship management programs for ... WRB will join ... commercialization support services for manufacturers, biotech firms, and other ...
Breaking Medicine Technology: