Navigation Links
Are living liver donors at risk from life-threatening 'near-miss' events?
Date:4/25/2013

A study published in Liver Transplantation, a journal of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, reports that donor mortality is about 1 in 500 donors with living donor liver transplantation (LDLT). Research of transplant centers around the world found that those with more experience conducting live donor procedures had lower rates of aborted surgery and life-threatening "near-miss" events.

For patients with end-stage liver disease, liver transplantation is their only option to prolong life. However, more than 16,000 Americans are currently on the waiting list for a liver according to the Organ Procurement and Transplantation Network (OPTN). The critical shortage of deceased donor organs has increased LDLTa procedure that uses a healthy portion of the liver from a living donor for transplant. Although prior research shows that LDLT is an effective treatment, a 2007 study by de Villa et al. found that LDLT accounts for less than five percent of liver transplants in the U.S. and Europe.

"Donors who decide to provide a portion of their liver to a loved one in need are making an extremely difficult decision to save the life of another," explains lead author Dr. Elizabeth Pomfret, Professor of Surgery at Tufts University and Chair of the Department of Transplantation and Hepatobiliary Diseases at Lahey Hospital & Medical Center in Burlington, Mass. "It is our responsibility as transplant specialists to provide donors with comprehensive information and education relating to LDLT, including any risks, so they may make informed decisions about donation."

To extend understanding of potential risks for liver lobe donors, the team conducted a web-based survey of 148 transplant centers around the world that perform LDLTs. Center representatives were asked to provide donor demographics; morbidity and mortality incidence; "near-miss" event data, and number of aborted procedures. Potentially life-threatening "near-miss" events included severe intraoperative bleeding, reoperation for bleeding, biliary reconstruction and pulmonary embolism.

A total of 71 centers (48%) responded to the survey, representing 21 countries, and performing 11,553 LDLTs procedures. Analysis shows that donor morbidity was 24% including five donors who required liver transplantation. Donor mortality was 0.2% (23/11,553), with the majority of deaths occurring within 60 days post-transplant and 19 deaths were a direct result of transplant surgery. Researchers reported that "near-miss" event and aborted surgery incidence was 1.1% and 1.2%, respectively.

Dr. Pomfret concludes, "It appears that the 0.2% donor mortality rate was consistent and independent of the center's experience performing LDLTs. However, increased experiencecenters performing more than 50 total LDLTsis associated with lower rates of aborted procedures and "near-miss" events. These potentially life-threatening complications must be discussed as part of the informed consent with any potential liver donor."

In a related editorial, Dr. Daniela Ladner, Assistant Professor of Surgery at Northwestern University Feinberg School of Medicine in Chicago, IL agrees, "Living liver donation is arguably the most invasive operation we as surgeons perform in willing patients with no demonstrable medical benefit, allowing them to donate a portion of their liver to save the life of someone with end-stage liver disease. As Dr. Pomfret and colleagues suggest, transplant surgeons are obligated to fully disclose all potential risk to donors." Dr. Ladner also suggests that all complications as well as near-miss events that did not reach the patient should be captured and systematically examined to identify areas of improvement with LDLT procedures and reduce life-threatening events for living donors.


'/>"/>

Contact: Dawn Peters
sciencenewsroom@wiley.com
781-388-8408
Wiley
Source:Eurekalert

Related medicine news :

1. BMA Affordable Assisted Living to Host "Meet & Greet" with U.S. Rep. John Shimkus
2. Living in Stroke Belt as Teen May Raise Future Risk
3. “Mentally Retarded” Autistic Mute Breaks Her Silence, Joins Forces with Her Psychologist and Friend to Write Life Affirming Memoir on Living with Autism
4. The Learning Curve of Living With Aspergers
5. Cellulite Factor: Review Examining Dr. Charles Livingston’s Immediate Download Program Released By CelluliteFactorReviews.org
6. San Luis Obispo-Assisted Living Facility The Manse On Marsh Launches New Online Virtual Tour To Showcase Its Interior Details
7. Novel Drug Treatment Quickly Reverses Alzheimer’s Disease Resulting in a Significant Reduction in Assisted Living Expenses
8. Spencer Institute’s Mind Body Fitness Certification Integrates Best of Mental and Physical Training to Promote Healthy Living
9. Living Well Assisted Living at Home Hosts Ongoing Support Group for Patients with Early Onset Alzheimer’s
10. Arizona Assisted Living Placement Service Above and Beyond Is Offering New Promotion for Clients
11. Blood Drive at Crimson Pointe Assisted Living Facility with Rock River Valley Blood Center
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... 2017 , ... Apple Rehab Shelton Lakes , which specializes in the ... facility as part of a disaster drill on October 3rd. , Apple Rehab participated ... Emergency Manager, as well as the Connecticut Long Term Care Mutual Aid Plan ...
(Date:10/13/2017)... ... 13, 2017 , ... Yisrayl Hawkins, Pastor and Overseer at The House of ... popular and least understood books in the Holy Scriptures, Revelation. The Book of Revelation ... scholars for centuries. Many have tossed it off as mere rubbish, but Yisrayl Hawkins ...
(Date:10/12/2017)... ... October 12, 2017 , ... First Healthcare Compliance (FHC), ... will showcase a range of technology and learning solutions at the 68th Annual ... Expo to be held October 14–18, 2017 at the Mandalay Bay Resort in ...
(Date:10/12/2017)... ... October 12, 2017 , ... The American College of ... Carol Friedman, PhD, FACMI, during the Opening Session of AMIA’s Annual Symposium in Washington, ... In honor of Morris F. Collen, a pioneer in the field of medical informatics, ...
(Date:10/12/2017)... ... October 12, 2017 , ... Leading pediatric oncology experts at ... for the 49th Congress of the International Society of Paediatric Oncology (SIOP) ... Center for Cancer and Blood Disorders at Children’s National, and Stephen P. ...
Breaking Medicine News(10 mins):
(Date:10/4/2017)... 4, 2017  South Korean-based healthcare product Development Company ... "cprCUBE" on Kickstarter. The device will educate the user ... with better efficiency compared to the dated and pricey ... on efficacy of the compression for a more informed ... goal to raise $5,000. ...
(Date:10/2/2017)... , Oct. 2, 2017 Diplomat Pharmacy, Inc. ... Day Software and Consulting, LLC , and named its ... Software, based in Tennessee , will ... Day expands EnvoyHealth,s service offerings for health care partners ... "In an interoperable world, ...
(Date:10/2/2017)... , Oct. 2, 2017 Halo Labs announces the European ... system called the HORIZON at MIBio 2017 in Cambridge, ... and visible particulate matter in biopharmaceutical samples with unprecedented speed and ... the novel technique Backgrounded Membrane Imaging. ... The HORIZON subvisible particle analysis system ...
Breaking Medicine Technology: