Navigation Links
Are developing heart valves sensitive to environmental chemicals?
Date:1/23/2014

Baltimore, MDExposure to environmental endocrine disrupters, such as bisphenol A, which mimic estrogen, is associated with adverse health effects. Bisphenol A is commonly found in plastic bottles and plastic food containers. New research from a team including Carnegie's Daniel Gorelick and Marnie Halpern on the effects of these chemicals on zebrafish shows that embryonic heart valves could be particularly in danger. It is published by Environmental Health Perspectives.

Estrogen hormones are important in all stages of life. They work by binding to receptors inside a cell, which then travel to the nucleus and act on the DNA by turning select genes on and off. But some synthetic chemicals mimic these estrogen hormones by also binding to the receptors. Exposure to them during early development is associated with increased risk of cancers and abnormal formation of the reproductive tract. So detecting such chemicals and identifying their mechanisms of action is of great importance for developmental scientists.

Gorelick, the lead author, Halpern and Alice Hung of Carnegie, along with Luke Iwanowicz and Vicki Blazer of the Fish Health Branch of the U.S. Geological Survey, used genetically modified zebrafish that show estrogen receptor activity on a cell's DNA.

Their findings indicate that these specially developed zebrafish are great tools not only for detecting environmental endocrine disruptors from river water, but also for identifying which tissues are targeted by these endocrine disruptors

Unexpectedly, estrogen receptors in the developing heart valves were activated by some water samples, which had not been observed previously. This raises interesting questions about the role of estrogen in valve formation and whether environmental chemicals could contribute to valve abnormalities.


'/>"/>

Contact: Marnie Halpern
halpern@ciwemb.edu
410-246-3018
Carnegie Institution
Source:Eurekalert  

Page: 1

Related medicine news :

1. Patients with multiple sclerosis in Taiwan may be at increased risk of developing cancer
2. PhUSE Working Group Active in Developing Standard Analysis Scripts
3. Craig Stephens as a Marketing Specialist for Plastic Surgeons Offers a Decidedly Unique Approach to Surgeons for Developing Their Online Presence
4. ATA Developing Accreditation of Online Medical Services
5. Study identifies protein that helps developing germ cells wipe genes clean of past imprints
6. Obesity found to be major risk factor in developing basal-like breast cancer
7. CFAST Sparks Pathways for Developing New Therapeutics for Unmet Patient Needs
8. KidsCareEverywhere Brings the Latest Medical Information to Developing Countries
9. Mediaplanet to Release Call-To-Action Campaign Encouraging Americans to Invest in Disaster Relief in the Developing World
10. Bumps in the road to developing long-lasting, single-injection nerve blocks
11. Diet Doc Hormone Diets & Weight Loss Plans Offers New Choice for Reducing Body Fat Content and Lowering the Risk for Developing Cancer Symptoms
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Are developing heart valves sensitive to environmental chemicals?
(Date:2/5/2016)... ... , ... Stuart Bentkover, MD, FACS is thrilled to announce the ... effective tattoo removal today, Dr. Bentkover is the only doctor in Central Massachusetts to ... has been approved by the Food and Drug Administration (FDA) as a safe and ...
(Date:2/5/2016)... ... , ... In sleep, when the defenses of the day are at rest, ... with eating disorders is significant self-criticism, and consequently these patients experience this disease with ... maladaptive means for coping with this unease, but also leads to a reservoir of ...
(Date:2/5/2016)... ... February 05, 2016 , ... On June 9-10, ... a continuing medical education (CME) event presented by the Association for Comprehensive Care ... first for ACCORD, whose mission is to provide education, tools, and resources to ...
(Date:2/5/2016)... ... February 05, 2016 , ... –This week, Atascadero water heater ... having a tankless water heater. To view the report, click here or ... tankless. While each has their pros and cons, the type chosen is almost entirely ...
(Date:2/4/2016)... ... February 04, 2016 , ... Dr. Carol Francis and ... February 19-21, 2016, in Southern California . The International Hypnosis Federation 2016 Conference ... professional speakers, including Clinical Psychologist and Hypnotherapist Dr. Carol Francis (topics ...
Breaking Medicine News(10 mins):
(Date:2/5/2016)...  ivWatch, a medical devices company, is one of five ... Governor Terry McAuliffe,s office. ivWatch will be receiving ... an event to be held at the Science Museum of ... and business that have made significant contributions to science. ... http://photos.prnewswire.com/prnh/20160205/330117LOGO ...
(Date:2/5/2016)... 5, 2016 ... the "Global Musculoskeletal Partnering 2010-2016: Deal ... to their offering. --> ... the "Global Musculoskeletal Partnering 2010-2016: Deal ... to their offering. --> ...
(Date:2/5/2016)... BEIJING , Feb. 5, 2016 ... ("Dehaier Medical" or the "Company"), which develops, markets ... products in China and ... restructuring plan which aims to concentrate the Company,s ... wearable sleep respiratory business and to focus more ...
Breaking Medicine Technology: