Navigation Links
Are developing heart valves sensitive to environmental chemicals?
Date:1/23/2014

Baltimore, MDExposure to environmental endocrine disrupters, such as bisphenol A, which mimic estrogen, is associated with adverse health effects. Bisphenol A is commonly found in plastic bottles and plastic food containers. New research from a team including Carnegie's Daniel Gorelick and Marnie Halpern on the effects of these chemicals on zebrafish shows that embryonic heart valves could be particularly in danger. It is published by Environmental Health Perspectives.

Estrogen hormones are important in all stages of life. They work by binding to receptors inside a cell, which then travel to the nucleus and act on the DNA by turning select genes on and off. But some synthetic chemicals mimic these estrogen hormones by also binding to the receptors. Exposure to them during early development is associated with increased risk of cancers and abnormal formation of the reproductive tract. So detecting such chemicals and identifying their mechanisms of action is of great importance for developmental scientists.

Gorelick, the lead author, Halpern and Alice Hung of Carnegie, along with Luke Iwanowicz and Vicki Blazer of the Fish Health Branch of the U.S. Geological Survey, used genetically modified zebrafish that show estrogen receptor activity on a cell's DNA.

Their findings indicate that these specially developed zebrafish are great tools not only for detecting environmental endocrine disruptors from river water, but also for identifying which tissues are targeted by these endocrine disruptors

Unexpectedly, estrogen receptors in the developing heart valves were activated by some water samples, which had not been observed previously. This raises interesting questions about the role of estrogen in valve formation and whether environmental chemicals could contribute to valve abnormalities.


'/>"/>

Contact: Marnie Halpern
halpern@ciwemb.edu
410-246-3018
Carnegie Institution
Source:Eurekalert  

Page: 1

Related medicine news :

1. Patients with multiple sclerosis in Taiwan may be at increased risk of developing cancer
2. PhUSE Working Group Active in Developing Standard Analysis Scripts
3. Craig Stephens as a Marketing Specialist for Plastic Surgeons Offers a Decidedly Unique Approach to Surgeons for Developing Their Online Presence
4. ATA Developing Accreditation of Online Medical Services
5. Study identifies protein that helps developing germ cells wipe genes clean of past imprints
6. Obesity found to be major risk factor in developing basal-like breast cancer
7. CFAST Sparks Pathways for Developing New Therapeutics for Unmet Patient Needs
8. KidsCareEverywhere Brings the Latest Medical Information to Developing Countries
9. Mediaplanet to Release Call-To-Action Campaign Encouraging Americans to Invest in Disaster Relief in the Developing World
10. Bumps in the road to developing long-lasting, single-injection nerve blocks
11. Diet Doc Hormone Diets & Weight Loss Plans Offers New Choice for Reducing Body Fat Content and Lowering the Risk for Developing Cancer Symptoms
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Are developing heart valves sensitive to environmental chemicals?
(Date:3/23/2017)... ... March 23, 2017 , ... The physicians of KSF Orthopaedic Center PA ... Area. The new location is located at 2255 E. Mossy Oaks Rd., Suite 440, ... newest location will provide patients living in the north Houston area (The Woodlands, Conroe, ...
(Date:3/23/2017)... , ... March 23, 2017 , ... The IoT (Internet ... WiFi connectivity are making a huge impact on businesses and individual consumers alike. ... the IoT will have a value anywhere from $4 trillion to $11 trillion dollars ...
(Date:3/23/2017)... ... March 23, 2017 , ... March is National Kidney Month – the perfect ... comes to maintaining good health. Every day, two kidneys filter about 120 to 150 ... of your blood, eliminating waste, regulating fluid levels and blood pressure, supporting bone health ...
(Date:3/23/2017)... Malvern, PA (PRWEB) , ... March 23, 2017 ... ... a comprehensive educational training program owned and organized by HMP Communications Holdings, LLC, ... training program for physicians within its nationwide network of wound centers interested in ...
(Date:3/23/2017)... ... March 23, 2017 , ... After raising more than $1.135 ... the most-funded travel pillow in crowdfunding history, has established a U.S. Headquarters ... popular travel innovation to Americans. , “We’re excited to be operating on U.S. shores, ...
Breaking Medicine News(10 mins):
(Date:3/23/2017)... , March 23, 2017  Ethicon* today announced ... Inc., a privately held medical device company that ... for the surgical treatment of Gastroesophageal Reflux Disease ... of expanding its portfolio of minimally invasive options ... conditions. Financial terms of the transaction have not ...
(Date:3/23/2017)... YORK , March 23, 2017 ... sample preparation market is expected to reach USD 7.2 billion ... of 7.1%. Sample preparation is a procedure in which a ... crucial step in most analytical procedures since the methods are ... preparation is one of the most shared procedures in the ...
(Date:3/23/2017)... 23, 2017  Drug diversion is a significant ... deadly overdoses. A new oral fluid monitoring test, ... , reports more detailed and actionable information to ... improve therapy adherence, patient safety, and help to ... Oral fluid Rx Evaluation (CORE) system is the ...
Breaking Medicine Technology: