Navigation Links
Are developing heart valves sensitive to environmental chemicals?
Date:1/23/2014

Baltimore, MDExposure to environmental endocrine disrupters, such as bisphenol A, which mimic estrogen, is associated with adverse health effects. Bisphenol A is commonly found in plastic bottles and plastic food containers. New research from a team including Carnegie's Daniel Gorelick and Marnie Halpern on the effects of these chemicals on zebrafish shows that embryonic heart valves could be particularly in danger. It is published by Environmental Health Perspectives.

Estrogen hormones are important in all stages of life. They work by binding to receptors inside a cell, which then travel to the nucleus and act on the DNA by turning select genes on and off. But some synthetic chemicals mimic these estrogen hormones by also binding to the receptors. Exposure to them during early development is associated with increased risk of cancers and abnormal formation of the reproductive tract. So detecting such chemicals and identifying their mechanisms of action is of great importance for developmental scientists.

Gorelick, the lead author, Halpern and Alice Hung of Carnegie, along with Luke Iwanowicz and Vicki Blazer of the Fish Health Branch of the U.S. Geological Survey, used genetically modified zebrafish that show estrogen receptor activity on a cell's DNA.

Their findings indicate that these specially developed zebrafish are great tools not only for detecting environmental endocrine disruptors from river water, but also for identifying which tissues are targeted by these endocrine disruptors

Unexpectedly, estrogen receptors in the developing heart valves were activated by some water samples, which had not been observed previously. This raises interesting questions about the role of estrogen in valve formation and whether environmental chemicals could contribute to valve abnormalities.


'/>"/>

Contact: Marnie Halpern
halpern@ciwemb.edu
410-246-3018
Carnegie Institution
Source:Eurekalert  

Page: 1

Related medicine news :

1. Patients with multiple sclerosis in Taiwan may be at increased risk of developing cancer
2. PhUSE Working Group Active in Developing Standard Analysis Scripts
3. Craig Stephens as a Marketing Specialist for Plastic Surgeons Offers a Decidedly Unique Approach to Surgeons for Developing Their Online Presence
4. ATA Developing Accreditation of Online Medical Services
5. Study identifies protein that helps developing germ cells wipe genes clean of past imprints
6. Obesity found to be major risk factor in developing basal-like breast cancer
7. CFAST Sparks Pathways for Developing New Therapeutics for Unmet Patient Needs
8. KidsCareEverywhere Brings the Latest Medical Information to Developing Countries
9. Mediaplanet to Release Call-To-Action Campaign Encouraging Americans to Invest in Disaster Relief in the Developing World
10. Bumps in the road to developing long-lasting, single-injection nerve blocks
11. Diet Doc Hormone Diets & Weight Loss Plans Offers New Choice for Reducing Body Fat Content and Lowering the Risk for Developing Cancer Symptoms
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Are developing heart valves sensitive to environmental chemicals?
(Date:6/27/2016)... ... June 27, 2016 , ... TherapySites, ... today its affiliation with Tennessee Counseling Association. This new relationship allows ... the Tennessee Counseling Association, adding exclusive benefits and promotional offers. , "TCA is ...
(Date:6/26/2016)... N.J. (PRWEB) , ... June 27, 2016 , ... Quality ... sources, yet in many ways they remain in the eye of the beholder, according ... (EBO), a publication of The American Journal of Managed Care. For the full issue, ...
(Date:6/26/2016)... ... 26, 2016 , ... Brent Kasmer, a legally blind and certified personal trainer is helping to ... app. The fitness app plans to fix the two major problems leading the fitness industry ... fits all type program , They don’t eliminate all the reasons people quit ...
(Date:6/25/2016)... (PRWEB) , ... June 25, 2016 , ... The temporary closing of Bruton Memorial Library ... City Observer , brings up a new, often overlooked aspect of head lice: the parasite’s ... for fumigation is not a common occurrence, but a necessary one in the event that ...
(Date:6/25/2016)... ... June 25, 2016 , ... Dr. Calvin Johnson ... Recently, he has implemented orthobiologic procedures as a method for treating his patients. ... the first doctors to perform the treatment. Orthobiologics are substances that orthopaedic surgeons ...
Breaking Medicine News(10 mins):
(Date:6/26/2016)... LAS VEGAS , June 26, 2016 ... movement to value-based care operating models within the health ... that enable greater financial efficiency , Deloitte offers ... address the key business issues impacting efficient cost optimization: ... alignment , These services facilitate better outcomes and ...
(Date:6/24/2016)... 24, 2016   Bay Area Lyme Foundation ... Dean Center for Tick Borne Illness , Harvard ... MIT Hacking Medicine, University of California, Berkeley, and ... the five finalists of Lyme Innovation , ... than 100 scientists, clinicians, researchers, entrepreneurs, and investors ...
(Date:6/24/2016)... -- Dehaier Medical Systems Ltd. (NASDAQ: DHRM ... sells medical devices and wearable sleep respiratory products in ... agreement with Hongyuan Supply Chain Management Co., Ltd. (hereinafter ... 2016, to develop Dehaier,s new Internet medical technology business. ... leverage Hongyuan Supply Chain,s sales platform to reach Dehaier,s ...
Breaking Medicine Technology: