Navigation Links
Are dead cancer cells feeding cancer's spread?
Date:6/14/2010

BIRMINGHAM, Ala. Researchers with the University of Alabama at Birmingham (UAB) Comprehensive Cancer Center and UAB Department of Chemistry have won an $805,000 grant from the U.S. Department of Defense Breast Cancer Research Program to study whether dead cancer cells left over after treatment encourage cancer's spread to other parts of the body.

The research centers on examining inactivated or altered genetic material (DNA) left in the body after breast-cancer cells are exposed to chemotherapy. UAB researchers say the resulting altered DNA may be the factor that activates the spread of living cancer cells to distant locations in the body a deadly process called metastasis through a specific molecular pathway.

Learning more about this metastasis pathway could lead to major improvements in prevention, treatment and follow-up care for millions of cancer patients, says Katri Selander, M.D., Ph.D., an assistant professor in the UAB Division of Hematology and Oncology and co-principal researcher on the grant.

"What if by killing cancer cells with chemotherapy we inadvertently induce DNA structures that make surviving cancers cells more invasive? The idea is tough to stomach," Selander says. "Fundamentally this question must be answered to advance the knowledge base and to know all the risks and benefits of cancer treatment.

"This research has the potential to reach across numerous scientific disciplines, and may one day improve the lives of patients worldwide."

Metastasis is the No. 1 cause of cancer recurrence and treatment failure.

The new grant expands on a research partnership between Selander and her team of researchers and those working in the laboratory of David Graves, Ph.D., chair of the UAB Department of Chemistry. Graves and his team are characterizing the DNA structures and other factors that induce metastasis in surviving cancer cells.

The pathway activated by the dead cancer cells is med
'/>"/>

Contact: Troy Goodman
tdgoodman@uab.edu
205-934-8938
University of Alabama at Birmingham
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Targeted therapy prolongs life in patients with HER2-positive breast cancer
2. New Drugs, New Combinations Fight Breast Cancer
3. Study Finds Possible Explanation for the Link Between Infertility and Breast/Ovarian Cancer Risks
4. MDS Nordions TheraSphere(R) for Unresectable Liver Cancer (HCC) Now Covered by Two Large U.S. Insurers
5. National Oncologist Group Warns: Current Health Care Reform Legislation Woefully Short In Addressing Cancer Care Crisis
6. Panel calls for reducing colorectal cancer deaths by striking down barriers to screening
7. Lung Cancer: Large Impact, Little Funding
8. Inflammation marker related to obesity is elevated in patients with pancreatic cancer
9. Prolactin blocks oncogene associated with poor prognosis in breast cancer
10. Older female cancer survivors have added health issues compared to their counterparts
11. Definitive study confirms chemo benefit in postmenopausal breast cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... With the arrival of summer, VisitandCare.com today ... and hair transplant procedures, up 80 percent from July ... medical tourism destinations, the company is helping patients take ... achieve the look they have always desired. , ... in the medical tourism industry, VisitandCare.com is comprised of ...
(Date:7/11/2014)... Steven Reinberg HealthDay ... Stress, hostility and depression may increase the risk for stroke, ... seemed to raise the risk of a stroke or ... found that stress apparently raised stroke or TIA risk by ... A TIA is a mini-stroke caused by a temporary blockage ...
(Date:7/11/2014)... (PRWEB) July 11, 2014 Fadhits.com, the ... its elegant assortment of lace holiday dresses . ... products are now offered at discounted prices, up to ... website can enjoy this special offer. , Fadhits.com ... and special occasion dresses for the global clients. All ...
(Date:7/11/2014)... San Francisco shows that an "expressive therapy" group ... living with HIV disclose their health status and ... and quality of their relationships., "Medication alone is ... L. Machtinger, MD, director of the Women,s HIV ... patients are on effective antiretroviral therapy but far ...
(Date:7/11/2014)... CA (PRWEB) July 11, 2014 Bedros Keuilian ... expert; a title he’s earned by founding the fast-selling fitness ... on marketing their businesses. He works with successful boot camp ... blog post on the traits of the most successful boot ... share three important qualities. , “I’ve worked with and coached ...
Breaking Medicine News(10 mins):Health News:VisitandCare.com Reports Increase in Cosmetic and Hair Transplant Procedures for Men 2Health News:VisitandCare.com Reports Increase in Cosmetic and Hair Transplant Procedures for Men 3Health News:Stress, Depression May Boost Stroke Risk, Study Finds 2Health News:Stress, Depression May Boost Stroke Risk, Study Finds 3Health News:Elegant Lace Holiday Dresses Released by Fadhits.com 2Health News:'Expressive therapy" intervention assists women living with HIV 2Health News:Fitness Boot Camp Marketing Expert Bedros Keuilian Shares the Top Three Traits of Successful Boot Camp Owners 2Health News:Fitness Boot Camp Marketing Expert Bedros Keuilian Shares the Top Three Traits of Successful Boot Camp Owners 3
... a leader in the field of clinical supply chain management, announced today ... the MHS Board of Directors. www.mhsinc.com , ... Fairfield, Connecticut ... a leader in the field of clinical supply chain management, announced today ...
... A team of Slimband employees successfully competed in the 19th Annual Canada Life ... , ... ON (PRWEB) April 22, 2009-- A team of Slimband employees successfully ... took place on April 16th. The CN Tower Climb is a demanding ...
... Committee,s (SASC) report on detainee abuse, Physicians for Human Rights (PHR) ... for the Central Intelligence Agency (CIA) and Department of Defense (DoD), ... , ... (Vocus) April 21, 2009 -- In the wake ...
... Only two percent of hospitals nationwide receive Magnet ... Center (ANCC) has announced that Baylor University ... earned re-designation as a Magnet hospital, effective immediately. ... been designated at a Magnet hospital, and merely ...
... to Save Millions of Plastic Bags from LandfillsITASCA, Ill., ... drug retailer, is partnering with WFLD FOX Chicago this ... Reuse" challenge, an initiative aimed at increasing consumer use ... plastic bags from ending up in area landfills. The ...
... 21 Carl Icahn announced today that he had sent the following letter to Joseph C. Cook, ... AMLN ) concerning recent discussions between Mr. Icahn and Messrs. Cook and Wilson , , ... ... April 21, 2009, Joseph Cook, Jr., Chairman of ...
Cached Medicine News:Health News:Daniel C. Lubin Joins Management Health Solutions, Inc. Board of Directors 2Health News:Slimband™ Team Competes in CN Tower Climb and Helps Fight Against Global Warming 2Health News:PHR: After Senate Report, Psychologists Who Tortured Must Be Held to Account 2Health News:PHR: After Senate Report, Psychologists Who Tortured Must Be Held to Account 3Health News:PHR: After Senate Report, Psychologists Who Tortured Must Be Held to Account 4Health News:Baylor Dallas Nationally Recognized for Nursing Excellence 2Health News:JEWEL-OSCO & FOX Chicago Launch 'Choose to Reuse' Bag Program 2Health News:JEWEL-OSCO & FOX Chicago Launch 'Choose to Reuse' Bag Program 3Health News:Icahn Responds to Cook and Wilson 2Health News:Icahn Responds to Cook and Wilson 3Health News:Icahn Responds to Cook and Wilson 4
(Date:1/15/2014)... Jan. 15, 2014 Sono-Tek Corporation (OTC BB: SOTK) today ... 30, 2013, compared to sales of $2,202,000 for the prior ... this quarter has also shown growth over the preceding quarter,s ... of this fiscal year. Markets that experienced sales increases over ...
(Date:1/15/2014)... , Jan. 15, 2014  Research and Markets ( http://www.researchandmarkets.com/research/6k27gw/dental ... Consumables Market - Global Industry Analysis, Size, Share, Growth, ... their offering. (Logo: http://photos.prnewswire.com/prnh/20130307/600769 ... are used on patients in order to treat dental ...
(Date:1/15/2014)... Texas , Jan. 15, 2014  Novation, the leading ... awarded several new IT value-added reseller (VAR) national contracts ... IT goods and services at lower costs. These include ... services such as initiative assistance and ongoing IT consulting ...
Breaking Medicine Technology:Sono-Tek Announces Third Quarter Results 2Sono-Tek Announces Third Quarter Results 3Sono-Tek Announces Third Quarter Results 4Dental Consumables Market - Global Industry Analysis, Size, Share, Growth, Trends And Forecast, 2013 - 2018 2Dental Consumables Market - Global Industry Analysis, Size, Share, Growth, Trends And Forecast, 2013 - 2018 3New Novation Information Technology VAR Contracts Offer Significant Savings to Hospitals 2
... Niiki Pharma Inc. announced today that it has ... clinical trial of its lead product, NKP-1339. NKP-1339 is ... tumor survival and anti-apoptosis factor. The NKP-1339 ... in patients with advanced solid tumors resistant to multiple, ...
... 2012 ULURU Inc. (NYSE AMEX: ULU ... European license for Altrazeal® to include the Middle East and ... the territory, Helmut Kerschbaumer Chairman of Melmed Holdings AG, stated, ... marketing to the various sectors in these markets. We have ...
Cached Medicine Technology:Niiki Pharma Announces the Completion of Phase I Dose Escalation for First-in-Man Anti-Cancer Agent NKP-1339 2ULURU Inc. Extends the European Altrazeal® License to Include the Middle East and Africa 2
Easy-to-use system for displaced femoral neck fractures in the low demand patient....
The APR Hip System offers a complete line of stems to precisely match patients' anatomic needs and address surgeon preferences....
Dual offset femoral stems, hip stems that provide unique and competitive features....
The P.S.L. stem is manufactured from cobalt chrome and is available with or without porous coating to give the surgeon the option of utilizing either the cementless of cemented technique at his or he...
Medicine Products: