Navigation Links
Are dead cancer cells feeding cancer's spread?
Date:6/14/2010

BIRMINGHAM, Ala. Researchers with the University of Alabama at Birmingham (UAB) Comprehensive Cancer Center and UAB Department of Chemistry have won an $805,000 grant from the U.S. Department of Defense Breast Cancer Research Program to study whether dead cancer cells left over after treatment encourage cancer's spread to other parts of the body.

The research centers on examining inactivated or altered genetic material (DNA) left in the body after breast-cancer cells are exposed to chemotherapy. UAB researchers say the resulting altered DNA may be the factor that activates the spread of living cancer cells to distant locations in the body a deadly process called metastasis through a specific molecular pathway.

Learning more about this metastasis pathway could lead to major improvements in prevention, treatment and follow-up care for millions of cancer patients, says Katri Selander, M.D., Ph.D., an assistant professor in the UAB Division of Hematology and Oncology and co-principal researcher on the grant.

"What if by killing cancer cells with chemotherapy we inadvertently induce DNA structures that make surviving cancers cells more invasive? The idea is tough to stomach," Selander says. "Fundamentally this question must be answered to advance the knowledge base and to know all the risks and benefits of cancer treatment.

"This research has the potential to reach across numerous scientific disciplines, and may one day improve the lives of patients worldwide."

Metastasis is the No. 1 cause of cancer recurrence and treatment failure.

The new grant expands on a research partnership between Selander and her team of researchers and those working in the laboratory of David Graves, Ph.D., chair of the UAB Department of Chemistry. Graves and his team are characterizing the DNA structures and other factors that induce metastasis in surviving cancer cells.

The pathway activated by the dead cancer cells is mediated in the body as a protein called toll-like receptor 9, or TLR9. This protein is present in the immune system and in many types of cancer. If TLR9 boosts metastasis, then researchers will work on finding targeted therapies that block or regulate this molecular pathway, Selander says.

UAB's grant from the Department of Defense Breast Cancer Research Program is designed to reward innovative research projects that could lead to major scientific and health advances.


'/>"/>

Contact: Troy Goodman
tdgoodman@uab.edu
205-934-8938
University of Alabama at Birmingham
Source:Eurekalert

Related medicine news :

1. Targeted therapy prolongs life in patients with HER2-positive breast cancer
2. New Drugs, New Combinations Fight Breast Cancer
3. Study Finds Possible Explanation for the Link Between Infertility and Breast/Ovarian Cancer Risks
4. MDS Nordions TheraSphere(R) for Unresectable Liver Cancer (HCC) Now Covered by Two Large U.S. Insurers
5. National Oncologist Group Warns: Current Health Care Reform Legislation Woefully Short In Addressing Cancer Care Crisis
6. Panel calls for reducing colorectal cancer deaths by striking down barriers to screening
7. Lung Cancer: Large Impact, Little Funding
8. Inflammation marker related to obesity is elevated in patients with pancreatic cancer
9. Prolactin blocks oncogene associated with poor prognosis in breast cancer
10. Older female cancer survivors have added health issues compared to their counterparts
11. Definitive study confirms chemo benefit in postmenopausal breast cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/22/2017)... ... February 22, 2017 , ... The ... today, as organizations, advocates, and individuals join together to increase recognition about the ... ultimately save lives. , “Today we mark a nationwide movement to raise awareness ...
(Date:2/22/2017)... ... February 22, 2017 , ... A product of digesting a ... derive a heart-protective benefit from eating soy foods, while others do not, a University ... are able to produce equol—a substance made by some types of “good” gut bacteria ...
(Date:2/22/2017)... (PRWEB) , ... February 22, 2017 , ... Pet obesity ... and 54% of dogs, according to the Association for Pet Obesity Prevention (APOP). During ... key pet food issues such as the benefits of corn and grains, value of ...
(Date:2/22/2017)... ... 22, 2017 , ... In a recent article ... context (age, illness and life choices) should be dissociated from medical errors and ... In addition, all too often, studies regarding health system performance in other countries, ...
(Date:2/21/2017)... , ... February 21, 2017 , ... ... Nation Regional Medical Clinic in Durant, Oklahoma, on Feb. 21. , The celebration ... tours for community members, clinic employees, the construction team and tribal leadership. ...
Breaking Medicine News(10 mins):
(Date:2/22/2017)... , Feb 22, 2017 Research and ... Market Analysis & Trends - Industry Forecast to 2025" report to ... The Global ... around 5.2% over the next decade to reach approximately $2.1 billion by ... and forecasts for all the given segments on global as well as ...
(Date:2/22/2017)... Calif. , Feb. 22, 2017  Applied Silver, the ... Barnes to the company,s advisory board. Ms. Barnes is ... joining business, advertising, engineering, legal, and healthcare experts Scott ... John Goodrich , J. Tress Ritter , and ... BSN, CIC, FAPIC brings more than three decades of nationally ...
(Date:2/22/2017)... 2017 Oncternal Therapeutics, Inc., a clinical-stage ... and common malignancies, today announced the closing of ... intends to use the proceeds to further clinical ... advance preclinical development of a new ROR1-targeted antibody-drug ... first-in-class anti-ROR1 monoclonal antibody being developed to treat ...
Breaking Medicine Technology: