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Ardea Biosciences Reports Progress of Clinical Development Programs; Provides 2008 Outlook; Announces 2007 Financial Results and Provides 2008 Financial Guidance
Date:3/24/2008

IV programs;

-- Presented preclinical data demonstrating potent activity and favorable

resistance profiles for our non-nucleoside reverse transcriptase

inhibitor (NNRTI) family of compounds against HIV at the 15th Annual

Conference on Retroviruses and Opportunistic Infections (CROI);

-- Presented favorable anti-tumor preclinical data on RDEA119 at the 2007

AACR-NCI-EORTC International Conference on Molecular Targets and

Cancer Therapeutics; and

-- Relocated our corporate headquarters and research laboratories to San

Diego's biotechnology corridor.

2008 Anticipated Key Program Milestones

In 2008, Ardea anticipates accomplishing the following milestones:

HIV

-- Initiate a Phase 2b trial of RDEA806 in patients with HIV in the

second quarter of 2008;

-- Complete a first-in-human micro-dosing study of our second generation

NNRTI, RDEA427, in the first quarter of 2008;

-- Initiate a Phase 1 trial of RDEA427 in the second half of 2008; and

-- Present the full results of our Phase 2a proof-of-concept study of

RDEA806 at a scientific conference in the second half of 2008.

Gout/Inflammation

-- Initiate a Phase 2 dose-finding trial for the treatment of gout in

the second quarter of 2008 with results expected in the second half

of 2008; and

-- Initiate a Phase 2a trial with RDEA119 for the treatment of

inflammatory disease in the second quarter of 2008.

Cancer

-- Complete and report data from the Phase 1 trial of RDEA119 in

patients with advanced cancer in the second half of 2008;

-- Initiate Phase 2 trials of RDEA119 in combination with other anti

cancer agents in the second half of 2008; and

-- Initiate a Phase 1 trial of our second generation MEK inhibitor in

the second half of 2008.

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SOURCE Ardea Biosciences, Inc.
Copyright©2008 PR Newswire.
All rights reserved

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