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Archimedes Pharma Announces Major Fund Raising of GBP65 Million
Date:3/2/2010

PecFent

Archimedes' transformational product is PecFent, an innovative and highly differentiated fentanyl citrate nasal spray, for the rapid relief of breakthrough cancer pain, based on Archimedes' PecSys(TM) technology. Phase III data illustrates that PecFent has a potential best-in-class profile among fentanyl products for breakthrough cancer pain and is the first product to demonstrate onset of pain relief within five minutes of dosing.

PecFent is an aqueous fentanyl citrate solution utilising Archimedes' proprietary PecSys(TM) technology. The PecFent solution has a low viscosity and is easily delivered in a low volume of 100mcl using a nasal spray pump. The pump produces a fine mist of similarly sized spray droplets which are deposited into the front of the nostril. The calcium ions present on the nasal mucosa cause the pectin to form a thin gel layer, which allows fentanyl to be retained on the nasal mucosa, allowing a rapid but controlled absorption into the systemic circulation. The PecSys(TM) technology avoids problems associated with simple solutions used in nasal sprays, such as excessive levels of drug and dripping or swallowing of the drug solution.

Archimedes' technologies - ChiSys(R), PecSys(TM) and T
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