Navigation Links
Applying Parallel Pressure Improves Vascular Grafting
Date:6/8/2008

Finding could speed new tissue-engineered stem cell bypass procedures, study says

SUNDAY, June 8 (HealthDay News) -- Adding a little shear stress along a vascular bypass graft during the procedure may help hold it together better in the long run, according to a new study.

Researchers report that gradually adding parallel pressure -- as opposed to normal perpendicular pressure -- to adult stem cells used in a graft helps then bind to the surfaces of the vessel.

The finding, expected to be presented during the annual meeting of the Society for Vascular Surgery being held in San Diego, could help development of a new tissue-engineered stem cell vascular bypass graft.

Integrins, molecules important for cell attachment on the surface of the stem cells, appear to be stimulated by shear force, according to the study. This helps these cells to remain attached to the inside of blood vessels.

"Firm attachment of the stem cells to the vascular graft would allow for the formation of a confluent monolayer of cells in the hopes of improving graft function," lead researcher Dr. Paul J. Dimuzio, a vascular surgeon at Thomas Jefferson University in Philadelphia, said in a prepared statement.

During the study, the researchers exposed human adipose-derived stem cells (ASC) differentiated toward endothelial-like cells to physiological levels of shear stress. Measurements of integrin activity and cell attachment were taken on sample culture plates precoated with collagen I, fibronectin or gelatin -- all vascular basement membrane components.

Future experiments will evaluate how well the stem cell grafts function as a bypass for occluded arteries, according to one researcher.

More information

The U.S. National Heart, Lung, and Blood Institute has more about coronary artery bypass grafting.



-- Kevin McKeever



SOURCE: Society for Vascular Surgery, news release, June 7, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Parallel Software Announces Integrated Credit Card Processing for MacPractice MD, DDS, DC and 20/20
2. AARP: Under Heavy Economic Pressure, Hispanics 45+ Look To Workplace, Families
3. MultiVu Video Feed: Study in the New England Journal of Medicine Shows High Blood Pressure Drug Tekturna(R) Reduces Key Marker of Kidney Disease
4. Smith & Nephew Negative Pressure Wound Therapy Products To Be Available To Patients Through the Medicare Part B Competitive Bidding Process
5. Can SonicMood Help to Significantly Lower High Blood Pressure? The Latest Research Answers With a Resounding YES!
6. Brisk Walking Lowers Blood Pressure, Increases Fitness in Obese
7. Medlines Pressure Ulcer Prevention Program Addresses New CMS Deadline of October 1, 2008
8. NeoStem, Inc. Comments on Recent Selling Pressure
9. Home Blood-Pressure Monitoring Recommended
10. How does CO2 insufflation pressure affect proliferation and improve apoptosis?
11. Study: Doctors Not Always Sure When to Treat Blood Pressure in People With Diabetes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/24/2016)... ... June 24, 2016 , ... Those who have experienced ... feelings, many turn to unhealthy avenues, such as drug or alcohol abuse, as a ... has released tools for healthy coping following a traumatic event. , Trauma sufferers tend ...
(Date:6/24/2016)... ... ... Marcy was in a crisis. Her son James, eight, was out of control. Prone to ... , “When something upset him, he couldn’t control his emotions,” remembers Marcy. “If there ... my other children and say he was going to kill them. If we were ...
(Date:6/24/2016)... ... June 24, 2016 , ... Global law firm Greenberg Traurig, P.A. announced ... attorneys chosen by their peers for this recognition are considered among the top 2 ... received special honors as members of this year’s Legal Elite Hall of Fame: ...
(Date:6/24/2016)... CA (PRWEB) , ... June 24, 2016 , ... Comfort ... the American Cancer Society and the Road To Recovery® program to drive cancer patients ... seniors and other adults to ensure the highest quality of life and ongoing independence. ...
(Date:6/24/2016)... Plano, TX (PRWEB) , ... June 24, 2016 , ... ... taking part in Genome magazine’s Code Talker Award, an essay contest in which patients ... for an award to be presented at the 2016 National Society of Genetic Counselors ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... RIDGE, Ill. and INDIANAPOLIS ... of students receiving a Lilly Diabetes Tomorrow,s Leaders Scholarship ... The 2016 scholarship winners, announced today online at ... to let type 1 diabetes stand in the way ... Diabetes has supported the Foundation,s scholarship program since 2012, ...
(Date:6/23/2016)... Revolutionary technology includes multi-speaker listening to conquer ... in advanced audiology and hearing aid technology, has today ... world,s first internet connected hearing aid that opens up ...      (Photo: http://photos.prnewswire.com/prnh/20160622/382240 ) , ... , TwinLink™ - the first dual communication ...
(Date:6/23/2016)... -- The vast majority of dialysis patients currently receive ... usually 3 times a week, with treatment times averaging ... equipment preparation and wait time.  This regimen can be ... who are elderly and frail.  Many elderly dialysis patients ... for some duration of time. Residents in ...
Breaking Medicine Technology: