Navigation Links
Applying Parallel Pressure Improves Vascular Grafting
Date:6/8/2008

Finding could speed new tissue-engineered stem cell bypass procedures, study says

SUNDAY, June 8 (HealthDay News) -- Adding a little shear stress along a vascular bypass graft during the procedure may help hold it together better in the long run, according to a new study.

Researchers report that gradually adding parallel pressure -- as opposed to normal perpendicular pressure -- to adult stem cells used in a graft helps then bind to the surfaces of the vessel.

The finding, expected to be presented during the annual meeting of the Society for Vascular Surgery being held in San Diego, could help development of a new tissue-engineered stem cell vascular bypass graft.

Integrins, molecules important for cell attachment on the surface of the stem cells, appear to be stimulated by shear force, according to the study. This helps these cells to remain attached to the inside of blood vessels.

"Firm attachment of the stem cells to the vascular graft would allow for the formation of a confluent monolayer of cells in the hopes of improving graft function," lead researcher Dr. Paul J. Dimuzio, a vascular surgeon at Thomas Jefferson University in Philadelphia, said in a prepared statement.

During the study, the researchers exposed human adipose-derived stem cells (ASC) differentiated toward endothelial-like cells to physiological levels of shear stress. Measurements of integrin activity and cell attachment were taken on sample culture plates precoated with collagen I, fibronectin or gelatin -- all vascular basement membrane components.

Future experiments will evaluate how well the stem cell grafts function as a bypass for occluded arteries, according to one researcher.

More information

The U.S. National Heart, Lung, and Blood Institute has more about coronary artery bypass grafting.



-- Kevin McKeever



SOURCE: Society for Vascular Surgery, news release, June 7, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Parallel Software Announces Integrated Credit Card Processing for MacPractice MD, DDS, DC and 20/20
2. AARP: Under Heavy Economic Pressure, Hispanics 45+ Look To Workplace, Families
3. MultiVu Video Feed: Study in the New England Journal of Medicine Shows High Blood Pressure Drug Tekturna(R) Reduces Key Marker of Kidney Disease
4. Smith & Nephew Negative Pressure Wound Therapy Products To Be Available To Patients Through the Medicare Part B Competitive Bidding Process
5. Can SonicMood Help to Significantly Lower High Blood Pressure? The Latest Research Answers With a Resounding YES!
6. Brisk Walking Lowers Blood Pressure, Increases Fitness in Obese
7. Medlines Pressure Ulcer Prevention Program Addresses New CMS Deadline of October 1, 2008
8. NeoStem, Inc. Comments on Recent Selling Pressure
9. Home Blood-Pressure Monitoring Recommended
10. How does CO2 insufflation pressure affect proliferation and improve apoptosis?
11. Study: Doctors Not Always Sure When to Treat Blood Pressure in People With Diabetes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/27/2017)... ... 2017 , ... According to the American Cancer Society , the average ... 95%. Once the cancer spreads to other organs, bones, or lymph nodes, however, the ... avoid this latter group, tune in to Lifestyle Magazine on April 9, ...
(Date:3/27/2017)... ... March 27, 2017 , ... ... agreement to resolve the pending litigation between itself and 1800 Vending DBA Healthy ... Utah). , “I am thrilled to announce that we have now reached a ...
(Date:3/27/2017)... ... March 27, 2017 , ... Harris Communications, Inc., a leading provider of ... products to the Deaf Seniors of America Conference, April 4-7 at the Hotel Westin ... knowledgeable ASL friendly staff from Harris Communications and to try out the newest assistive ...
(Date:3/24/2017)... Hatboro, Pennsylvania (PRWEB) , ... March 24, 2017 ... ... and recycling solutions for contaminated soil, dredged material, and hazardous and non-hazardous materials ... headquartered in Allentown, Pennsylvania. This acquisition will add four additional processing facilities ...
(Date:3/24/2017)... ... , ... Digital Scientists, a software innovation lab specializing in web design and ... South Carolina location. The lab has set up shop at the renowned NEXT ... South Carolina clients for years from our office here in Atlanta,” explains Digital Scientists’ ...
Breaking Medicine News(10 mins):
(Date:3/24/2017)... 24, 2017  GenomeDx Biosciences today announced that six ... Decipher® Prostate Cancer Classifier tests will be presented at ... (EAU) Congress held March 24 to 28, 2017 in ... Congress is Europe,s largest urological ... the urological field. The abstract titled "Muscle ...
(Date:3/24/2017)... DALLAS , March 23, 2017  HealthMine surveys ... January 2017 revealed that health plan members want help ... reason to stay engaged in their health, 2) help ... an integrated platform for health and 5) relevant, real-time ... outcomes and lowering healthcare costs. ...
(Date:3/24/2017)... 2017  Provectus Biopharmaceuticals, Inc. (OTCQB: PVCT, ... oncology and dermatology biopharmaceutical company, today disclosed terms ... Sheet (the "Definitive Financing") it entered into on ... stockholders, who are referred to in the Definitive ... filed with the Securities and Exchange Commission.   ...
Breaking Medicine Technology: