Navigation Links
Applied nanobiomedicine: Exploiting nanoparticles to hunt for hidden cancer cells
Date:6/7/2012

The German Federal Ministry of Education and Research provides over 300,000 for the next three years to fund a new research project at the Mainz University Medical Center. The project aims to detect dispersed tumor cells in cancer patients. Latest reports indicate that such detached cancer cells could play an important role for the early detection of cancer. Also, they may provide important information whether patients are indeed responding to therapy. To overcome the current limitations precluding the routine detection of these rare cells, the research network seeks to exploit a novel combination of nanotechnology combined with principles underlying hard drive technology. The research team headed by Professor Dr. Roland Stauber of the Department of Otolaryngology, Head, and Neck Surgery at the Mainz University Medical Center is embedded in the recently initiated "Magnetic Flow Cytometry" (MRCyte) project.

Almost all forms of cancer occur much more frequently in older patients than in younger people. Demographic changes and the general increase in life expectancy mean that individuals are at increased risk of developing cancer. According to the Cancer Information Service (KID) of the German Cancer Research Center, it is expected that some 486,000 new cases of cancer will be reported in Germany in 2012. Despite innovative treatments and the fact that more and more people survive their illness, cancer is still one of the most common causes of death in Germany due to its increased prevalence.

In addition to the development of novel cancer treatment strategies, early disease detection and the monitoring of patient response is highly effective in reducing mortality. "Latest findings seem to indicate that dispersed tumor cells are actually an early warning signal not only of cancer development but also of relapse following therapy," explains project manager Professor Roland Stauber. The detection of such tumor cells in the blood of cancer patients is thus of particular interest in terms of both diagnosis and prognosis. However, before this knowledge can be exploited routinely in the clinics, the development of reliable and easy-to-use detection systems is a must. Such devices need to ensure that isolated tumor cells can be reliable and dynamically detected without the need for complex prior sample preparation. Hence, during the new research project, the researchers in Mainz and their collaborative partners from industry and academia are aiming at the development of a method that allows the concentration of rare cells in patients' blood by a novel combination of nanoparticle-based magnetic flow cytometry combined with hard drive read head detection technology. "Early detection is still the crucial factor in the fight against cancer. The strategy adopted in the MRCyte joint project is tremendously innovative and could well open up new dimensions for future treatment concepts," explains the Scientific Director of the Mainz University Medical Center, Professor Dr. Dr. Reinhard Urban.

Still, one of the main challenges prior to applying the research results from "bench to bedside" is based on the fact that cancer cells can vastly differ in terms of appearance, size, and composition compared to their healthy "sister" cells. This makes it even more difficult to reliably detect detached tumor cells. "Clearly, before our approach can be used on patients, extensive laboratory research is required," emphasizes Stauber. "Fortunately, our experience and developed technologies obtained during a previous project supported by the Rhineland-Palatinate Trust for Innovation will help us to rationally address these caveats in order to further improve patients' care procedures," Professor Roland Stauber is confidently looking ahead. The funding will therefore provide a decisive impetus for the implementation of innovative projects with a high practical relevance.


'/>"/>
Contact: Professor Dr. Roland H. Stauber
roland.stauber@unimedizin-mainz.de
49-613-117-7002
Johannes Gutenberg Universitaet Mainz
Source:Eurekalert

Related medicine news :

1. Applied Optics focus issue: Digital holography and 3-D imaging
2. Black Box Drug Warning Labels Applied Inconsistently: Study
3. Trauma surgeon leads call to action for pediatric applied trauma research network
4. Applied nuclear physics for biomedicine, nuclear security and basic science
5. Verdict Search recognizes Applied Forensics in Top 25 New York Verdicts of 2009
6. Evidence-based medicine theory can be applied to frequent flying says US professor
7. HOGGAN Ergo to Debut New Software and Sensor at the 2010 Applied Ergonomics Conference
8. Exploiting the architecture of cancers may lead to their destruction
9. Nanoparticles may enhance cancer therapy
10. Children may have highest exposure to titanium dioxide nanoparticles
11. UC Davis researchers refine nanoparticles for more accurate delivery of cancer drugs
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/21/2017)... ... ... PracticeMatch, a company that provides online resources , job boards ... like nurse practitioners and physician assistants , will conduct its first ... The online career fairs will allow job seekers to connect with healthcare employers from ...
(Date:8/21/2017)... (PRWEB) , ... August 21, 2017 , ... FCPX LUT ... Editors can quickly and easily add washed color grades to footage. A LUT ... LUT changes every pixel’s color to the corresponding color indicated by the table. This ...
(Date:8/21/2017)... (PRWEB) , ... August 21, 2017 , ... ... widely recognized community involvement program serving the people of Michigan. The new initiative ... almost 120 years at the very forefront of animal protection and welfare by ...
(Date:8/21/2017)... ... August 21, 2017 , ... San Diego physician and surgeon Dr. James Veltmeyer, ... announced his candidacy for the 52nd Congressional District currently held by Representative Scott Peters. ... to this country at age eleven after suffering homelessness and hardship in a distant ...
(Date:8/20/2017)... ... August 20, 2017 , ... HIPAA Solutions, ... System has assisted multiple clients in successfully passing audits such as Office ... Level 2 (AICPA SOC Level 2), and State Data Use Agreement Audits. ...
Breaking Medicine News(10 mins):
(Date:8/15/2017)... Aug. 15, 2017  AOTI Inc. announced today that its fully ... has recently opened a New York City Office in ... its unique Topical Wound Oxygen (TWO 2 ) homecare therapy. This ... Commission for Health Care (ACHC) under the company,s DMEPOS accreditation for ... ...
(Date:8/8/2017)... -- BioLineRx Ltd. (NASDAQ/TASE: BLRX), a clinical-stage biopharmaceutical company focused ... for the second quarter ended June 30, 2017. ... and to date: ... Company,s lead project, BL-8040: Announced plans ... novel stem cell mobilization treatment for autologous bone-marrow transplantation ...
(Date:8/7/2017)... , Aug. 7, 2017 Diplomat Pharmacy, Inc. (NYSE: ... Joel Saban as president, effective Aug. 7, 2017. ... has decided to pursue other interests and will serve as ... tenure, Paul has served us in multiple leadership roles since ... in Jun. 2015 and has provided decisive, strategic leadership which ...
Breaking Medicine Technology: