Navigation Links
Apples and oranges: Tumor blood vessel cells are remarkably atypical
Date:9/8/2008

Contrary to a long-standing assumption that blood vessel cells in healthy tissues and those associated with tumors are similar, a new study unequivocally demonstrates that tumor blood vessel cells are far from normal. The research, published by Cell Press in the September issue of the journal Cancer Cell, identifies tumor-specific blood vessel cells that are atypically stem cell-like and have the potential to differentiate into cartilage- or bone-like tissues.

Although it has been known for some time that tumors can be eradicated in mice by targeting their blood supply, very little is known about the biology of the endothelial cells that line tumor blood vessels (TECs). "A primary assumption of antiangiogenesis therapy is that TECs are normal and derived from nearby, preexisting vessels," explains senior author Dr. Michael Klagsbrun from Children's Hospital Boston and Harvard Medical School. "However, we and other groups have shown that there are several key differences between normal and tumor endothelium."

Dr. Klagsbrun and lead author Dr. Andrew Dudley isolated TECs from mice that spontaneously develop prostate tumors very similar to human prostate cancers. The researchers found that the TECs were multipotent, meaning that they were not fully mature and had the potential to differentiate into multiple different types of cells. The isolated TECs differentiated to form cartilage- and bone-like tissues. "These results suggest that TECs possess a stem/progenitor cell property that distinguishes them from ECs throughout the normal vasculature and undergo atypical differentiation," explains Dr. Klagsbrun.

The researchers went on to demonstrate blood vessel calcification in human and mouse prostate tumor specimens. This bone-like calcification has also been described in diseased blood vessels and is likely to have clinical significance in prostate cancer. "It is possible that calcification of tumor blood vessels could impair blood
'/>"/>

Contact: Cathleen Genova
cgenova@cell.com
617-397-2802
Cell Press
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Physicians ask EPA, Antibiotics to cure sick apples, or sick children?
2. AUDIO from Medialink and Apple Products Research and Education Council: New Research -- Adults Who Eat Apples, Apple Juice Have Healthier Diets and Lower Risk for Metabolic Syndrome
3. Adults who eat apples, drink apple juice have lower risk for metabolic syndrome
4. Drug Re-Sensitizes Breast Tumors to Treatment
5. Drug/radiation combo may help shrink established tumors
6. Childhood brain tumor traced to normal stem cells gone bad
7. Leading Neurosurgical Center in Moscow Purchases CyberKnife System to Expand Ability to Treat Brain and Spinal Tumors
8. Vitamin C injections slow tumor growth in mice
9. Turned-off cannabinoid receptor turns on colorectal tumor growth
10. Nanoparticles + light = dead tumor cells
11. Erectile dysfunction drugs allowed more chemotherapy to reach brain tumors in laboratory study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/26/2014)... WA (PRWEB) December 26, 2014 “Many ... deal with personal injury claim issues and phone calls ... recently released an article featuring their free eBook ... exceptionally helpful eBook on pedestrian and bicycle auto accident ... attorney is fully capable of professionally handling their case ...
(Date:12/25/2014)... The microscopy market is estimated ... reach $5,756.0 million by 2019. Optical microscopy is ... electron microscopes product segment is expected to show ... Rising focus on nanotechnology, technological advancements, and increasing ... market. , Get Full Copy of Report @ ...
(Date:12/25/2014)... York, New York (PRWEB) December 25, 2014 ... the 2010 DePuy ASR hip recall ( http://www.consumerinjurylawyers.com/DePuy/ ) ... LLP reports. According to an Order issued in the ... 20th, the Court will convene an open conference on ... Building and United States Courthouse in West Palm Beach, ...
(Date:12/25/2014)... Recently, BellasDress has launched ... wedding dresses. BellasDress has chosen their best-selling lace wedding ... for the holiday season. , Now, BellasDress.com features ... gowns here at discount prices. The business hopes everyone ... website. , “All our elegant products are ...
(Date:12/25/2014)... By Dennis Thompson ... -- Very sick children with complex chronic illnesses can receive ... a "medical home," with easy access to a team of ... were less likely to become seriously ill and need either ... received treatment at an enhanced medical home clinic at the ...
Breaking Medicine News(10 mins):Health News:Guide to Handling Pedestrian and Bicycle Accidents Released By The Jones Firm, Featured in Recent Article 2Health News:Microscopy Market Hit to $5,756.0 Million by 2019 - New Research Report by MarketsandMarkets 2Health News:Microscopy Market Hit to $5,756.0 Million by 2019 - New Research Report by MarketsandMarkets 3Health News:Microscopy Market Hit to $5,756.0 Million by 2019 - New Research Report by MarketsandMarkets 4Health News:Federal Court Overseeing DePuy ASR Hip Lawsuit Set to Convene Conference in January, Bernstein Liebhard LLP Reports 2Health News:Federal Court Overseeing DePuy ASR Hip Lawsuit Set to Convene Conference in January, Bernstein Liebhard LLP Reports 3Health News:BellasDress.com’s Christmas Sale: Trendy Wedding Dresses With Big Discounts 2Health News:Coordinated Care Through 'Medical Home' Best for Chronically Ill Kids: Study 2Health News:Coordinated Care Through 'Medical Home' Best for Chronically Ill Kids: Study 3
... - No Referrals Needed , CHICAGO , Jan. ... (BCBSIL) is offering individual and family dental plans to its members with ... access to one of the largest networks of contracting dentists and are ... Dental PPO plan has one of the highest maximum benefit levels with ...
... , WASHINGTON , Jan. 14 For those ... having trouble dealing with the images of the Haiti ... managing distress from afar and tips for recovering from disasters on ... of lost lives, the wounded and the destruction of homes and ...
... to Reduce Air Pollution , HARRISBURG, Pa. , Jan. 14 ... partnerships have forecast an air quality action day for Friday, Jan. ... Allegheny County , which includes Clairton , Glassport , ... , The air quality forecast predicts Friday will be code ORANGE for ...
... in part to more than a decade of preclinical ... preparing to develop and market throughout Asia a drug ... In a deal worth $272 million plus royalties, the ... compound bardoxolone methylor CDDO-methyl ester (CDDO-Me), in the scientific ...
... of those responding to Oregon poll said they tried the ... many as 6 percent of Oregon eighth-graders have tried the ... new report. , Also known as the "blackout game," "pass-out ... activity involves intentionally trying to strangle oneself or another by ...
... , NATIONAL CANCER INSTITUTE DISCONTINUES CANCER ... Jan. 14 As a result of the ... Service (CIS) Partnership Program throughout the United States , ... Center (NCCC) will no longer coordinate the program in ...
Cached Medicine News:Health News:Blue Cross and Blue Shield of Illinois Offers BlueCare Dental Plan 2Health News:APA Offers Resources on Managing Traumatic Stress in Wake of Haiti Earthquake 2Health News:APA Offers Resources on Managing Traumatic Stress in Wake of Haiti Earthquake 3Health News:Air Quality Action Day Forecast on Jan. 15 for Liberty/Clairton Region 2Health News:Kidney-disease drug with Dartmouth origins licensed in Asia 2Health News:Deadly 'Choking Game' Still Common Among Kids 2Health News:Deadly 'Choking Game' Still Common Among Kids 3Health News:Statewide Outreach & Information Service Program Operated by Northern California Cancer Center to End 2Health News:Statewide Outreach & Information Service Program Operated by Northern California Cancer Center to End 3
(Date:12/24/2014)... Dec. 24, 2014  Commonwealth Cornerstone Group (CCG) today announced ... transaction on Tuesday to help fund the expansion and consolidation ... Sharon . PHN is ... Pennsylvania . It is the largest employer in ... 150 people on staff. Currently, PHN Sharon offers ...
(Date:12/24/2014)... 24, 2014 Kinex Pharmaceuticals announced today that ... Roswell Park Cancer Institute. KX2-361 (KX02), a ... has shown potent inhibitory activity against a broad panel ... resistant to Temozolomide (T98G), the most widely used chemotherapy ... brain tumor mouse model, KX2-361 consistently clears brain tumors ...
(Date:12/24/2014)... Trade Commission (ITC) issued its final decision in the case ... issued on December 23, the ITC ruled in favor of ... invalid. BMC President, James Xu called ... the ITC,s decision in this case. This victory for us ... beginning on the key patents in the case. ResMed chose ...
Breaking Medicine Technology:Commonwealth Cornerstone Group Announces $8 Million in Tax Credits to Expand and Consolidate Healthcare Services in Sharon 2Commonwealth Cornerstone Group Announces $8 Million in Tax Credits to Expand and Consolidate Healthcare Services in Sharon 3Kinex Pharmaceuticals Announces First Patient Dosed with KX2-361 in a Phase 1 Clinical Study 2Kinex Pharmaceuticals Announces First Patient Dosed with KX2-361 in a Phase 1 Clinical Study 3ITC Final Decision Goes Against ResMed (RMD) Monumental Win for 3B/BMC 2
Algerbrush II corneal rust ring remover battery powered...
... the most complex grinding formula ... trial lens, are specifically manufactured ... and precision as the lenses ... RT-300 refractor. Marco custom trial ...
Khosla Mini Non-Illuminated Trial Lens Set, With Lenses Mounted...
Minus cylinders only trial lens set....
Medicine Products: