Navigation Links
Apples Help Keep Muscles Strong, Mouse Study Finds
Date:6/9/2011

THURSDAY, June 9 (HealthDay News) -- A natural compound found in apples may help prevent muscle wasting that can result from aging and illness, according to the results of a study in mice.

The benefit appears to come from a compound in apple skin called ursolic acid, according to Dr. Christopher Adams, of the University of Iowa in Iowa City, and colleagues.

Adams and colleagues first identified 63 genes that change in response to fasting in both people and mice, and another 29 that change their expression in the muscles of both people who are fasting and those with spinal cord injuries. They then looked at 1,300 small molecules and zeroed in on ursolic acid as a compound that might counteract muscle atrophy.

In the next phase, the researchers found that ursolic acid could protect against muscle wasting in mice that were deprived of food. They also found that adding ursolic acid to the food of normal mice for a number of weeks prompted muscle growth.

In addition, mice that received ursolic acid became leaner and had lower blood levels of glucose, cholesterol and triglycerides, the investigators found.

The health benefits noted in the mice were due to enhanced insulin signaling in muscle and to corrections in gene signatures associated with muscle atrophy, the researchers explained.

"Ursolic acid is an interesting natural compound," Adams said in a journal news release. "It's part of a normal diet as a component of apple peels. They always say that an apple a day keeps the doctor away....People who eat junk food don't get this."

It is not clear whether the findings in mice will be confirmed in human trials, however, and whether the amount of ursolic acid consumed as part of a normal diet would protect against the ravages of muscle wasting.

The findings, published in the June issue of the journal Cell Metabolism, might lead to the development of new drugs if confirmed in humans, the study authors suggested.

"Muscle wasting is a frequent companion of illness and aging," Adams said. "It prolongs hospitalization, delays recovery and in some cases prevents people from going back home. It isn't well understood and there is no medicine for it."

More information

The U.S. National Library of Medicine has more about muscle atrophy.

-- Robert Preidt

SOURCE: Cell Metabolism, news release, June 7, 2011


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Apples for me, Doritos for you: Consumers buy healthier foods for themselves
2. Apples Are the New Superfruit
3. Agency Pioneer SVH Tours & Travel Launches AppleSpecials.com, New Travel Booking Web Site that Showcases First-Hand Videos and Last Minute Specials
4. Surgery to repair torn shoulder muscles in the elderly can reduce pain and improve function
5. Brain stimulation can help partially paralyzed stroke patients regain use of their muscles
6. Clenching Muscles May Boost Willpower
7. Teens Breast-fed as Infants Have Stronger Leg Muscles
8. Penguins continue diving long after muscles run out of oxygen
9. Elevated protein levels in cardiac muscles could predict mortality following angioplasty
10. Protein drinks after exercise help maintain aging muscles
11. Tweens Can Take Charge of Their Health with New Book "Be Fit, Be Strong, Be You"
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Apples Help Keep Muscles Strong, Mouse Study Finds
(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... ... agency serving communities in the greater Dallas, Miami, and Raleigh regions, is organizing ... fighting to overcome a rare and deadly chromosome abnormality. , After struggling since ...
(Date:10/13/2017)... ... October 13, 2017 , ... The International ... promote standards of excellence for the field of eating disorders, announces the opening ... 25, 2018 in Orlando, Florida at the Omni Resort at ChampionsGate. ...
(Date:10/13/2017)... ... , ... Many families have long-term insurance that covers care for a family ... for care if the client has a cognitive impairment diagnosis. , “What this ... often waived, so the benefits from their insurance start immediately,” said Mechell Vieira, owner ...
(Date:10/13/2017)... ... October 13, 2017 , ... ... giving viewers the lowdown on sciatica in a new episode of "Success Files," ... on current events and innovation and investigates each subject in-depth with passion and ...
(Date:10/12/2017)... ... October 12, 2017 , ... CitiDent and San Francisco dentists, ... cutting-edge Oventus O2Vent technology. As many as 18 million Americans are estimated to ... breathing. Oral appliances can offer significant relief to about 75 percent of people ...
Breaking Medicine News(10 mins):
(Date:10/10/2017)... --  West Pharmaceutical Services, Inc. (NYSE: WST), a ... today shared the results of a study highlighting the ... administration of polio vaccines. The study results were presented ... by Dr. Ondrej Mach , Clinical Trials and ... and recently published in the journal Vaccine. i ...
(Date:10/4/2017)... SEOUL, South Korea , Oct. 4, 2017 /PRNewswire/ ... launched its next-generation CPR training aide "cprCUBE" on Kickstarter. ... of chest compression during cardiac arrests with better efficiency ... patient-mannequins. It also offers real-time feedback on efficacy of ... The crowdfunding campaign has a goal to raise ...
(Date:10/2/2017)... 2, 2017 Diplomat Pharmacy, Inc. (NYSE: ... and Consulting, LLC , and named its founder as ... in Tennessee , will operate under ... EnvoyHealth,s service offerings for health care partners to include ... "In an interoperable world, technology delivers ...
Breaking Medicine Technology: