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Aplenzin(TM), the Only Single Tablet Once-Daily Treatment for Depression at All Doses, Now Available in the United States
Date:4/7/2009

ine, an SSRI. Bupropion also has low incidence of weight gain compared to placebo. Research suggests that MDD may be caused by an imbalance of brain chemicals called neurotransmitters. The mechanism of action of Aplenzin is unknown; however, it is believed that bupropion, the active ingredient of Aplenzin, may help restore the balance of neurotransmitters, by inhibiting the reuptake of norepinephrine and dopamine.

Aplenzin was approved by the U.S. Food and Drug Administration (FDA) in April 2008. Sanofi-aventis U.S., which licensed Aplenzin from Biovail Corporation in December 2008, markets the product in the United States and Puerto Rico.

About Major Depressive Disorder

In the United States, it is estimated that between 10 percent and 25 percent of women and five percent and 12 percent of men will experience a major depressive episode at some point in their lives. Unlike normal emotional experiences of sadness, loss or passing mood states, MDD is persistent (it may last, on average, up to 16 weeks) and is usually associated with substantial symptom severity and role impairment, contributing to reduced productivity. According to one study, people with MDD reported an average of 35 days in the past year when they were unable to work or carry out their normal activities. MDD is associated with comorbid anxiety and substance abuse, and evidence suggests it is a significant risk factor for stroke, hypertension, heart disease, and death due to heart attack. The costs associated with MDD are greater than those from hypertension and equivalent to those of heart disease, diabetes and back problems combined.

Research shows that only 57 percent of patients with MDD are treated for depression in the primary care setting each year, with only one in five of these patients receiving adequate treatment. The most common treatments for MDD are antidepressants and psychotherapy.

About Aplenzin
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