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Aplenzin(TM), the Only Single Tablet Once-Daily Treatment for Depression at All Doses, Now Available in the United States
Date:4/7/2009

BRIDGEWATER, N.J., April 7 /PRNewswire-FirstCall/ -- Sanofi-aventis U.S. announced today that Aplenzin(TM) (bupropion hydrobromide) extended-release tablets, an effective bupropion therapy for the treatment of major depressive disorder (MDD), is now available by prescription in the United States for adults ages 18 and older. Aplenzin differs from other generic and branded bupropion antidepressants because it provides a unique HBr salt extended-release formulation, offering prescribers and their patients the benefit of convenience with simple one tablet, once-daily dosing at all doses.

"For patients who show little clinical improvement on lower doses of bupropion, there is a need to take higher doses to treat major depressive disorder," said Prakash Masand, M.D., Consulting Professor of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC. "Aplenzin offers patients and physicians an alternative option which only requires one tablet, once a day at the highest bupropion dose. This provides a simple, convenient option for patients that currently need to take two to three tablets daily."

For those patients in whom no clinical improvement is noted after several weeks of treatment at the target dose of 348 mg per day, Aplenzin offers physicians and their patients the ability to titrate up to the 522 mg strength. The Aplenzin 522 mg dose is the only FDA-approved single-tablet, once daily treatment equivalent to 450 mg of bupropion HCl therapy, requiring two or three tablets daily.

"With major depressive disorder affecting about 14 million Americans, we are excited to offer patients an effective treatment option that hopefully addresses existing unmet needs," said Brent Ragans, Vice President and Head of the General Therapeutics Business Unit, sanofi-aventis.

Bupropion, the active ingredient in Aplenzin, offers comparable efficacy to fluoxet
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SOURCE sanofi-aventis
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