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Apidra(R) SoloSTAR(R), the Easy-to-Use Insulin Delivery Device from sanofi-aventis, Now Available in the United States
Date:4/20/2009

/b>(R) pen must not be shared.

OptiClik(R) is a reusable insulin delivery device for use with a 3-mL Apidra(R) cartridge (U-100). Needles, OptiClik(R) and cartridge systems must not be shared.

Apidra(R) may also be infused subcutaneously by external insulin infusion pumps.

Apidra(R) has a more rapid onset and shorter duration of action than regular human insulin. When used as a mealtime insulin, Apidra(R) should be given within 15 minutes before or within 20 minutes after starting a meal. Do not change your dose or the type of insulin you use without talking with your treating healthcare provider. Tell your doctor about all of your medical conditions, as well as other medicines and supplements you are taking. Check your blood sugar levels while on insulin therapy, such as Apidra(R).

The most common side effect of insulin therapy, including Apidra(R), is low blood sugar (hypoglycemia). Other possible side effects may include low blood potassium, injection site reactions, such as changes in fat tissue at the injection site, and allergic reactions, such as itching and rash. Less common, but potentially more serious or life-threatening, is generalized allergy to insulin, including anaphylactic reactions.

When used in a pump, do not mix Apidra(R) with any other insulin or liquid.

If the pump or infusion set does not work right, you may not receive the right amount of insulin. Hypoglycemia, hyperglycemia, or ketosis can happen. Problems should be identified and corrected as quickly as possible. Change the Apidra(R) in the pump reservoir every 48 hours.

For full prescribing information, please visit www.Apidra.com.

IMPORTANT SAFETY INFORMATION FOR LANTUS(R)

Prescription Lantus(R) is
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SOURCE sanofi-aventis U.S.
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