Navigation Links
Aortic aneurysm treatable with asthma drugs
Date:11/16/2010

A new study from the Swedish medical university Karolinska Institutet shows that asthma drugs are a potential treatment for aortic aneurysm. These drugs, which block cysteinyl-leukotrienes, could reduce the break down of vessel wall tissue and the dilation of the aortic wall, and thus the risk of its rupturing. This could both save lives and reduce the need for complicated and risky surgery. The results are presented in the scientific journal PNAS.

Aortic aneurism is a life-threatening disease caused by the weakening of a section of the wall of the aorta, which then dilates and, in advanced cases, risks rupturing. If the condition is discovered in time, surgery is a possible course of action, but often the disease develops unnoticed, causing death by sudden and massive internal haemorrhage when the aneurysm bursts.

Aortic aneurysms are more common in the 65-plus age group, and amongst men. One of the causes of the disease is a chronic inflammatory, multi-signal molecule process which activates enzymes that slowly break down proteins and the various components of the vessel wall tissue. This promotes the development of the disease and the eventual rupture of the aorta.

Researchers at Karolinska Institutet have now discovered that the wall of an aortic aneurysm contains increased levels of enzymes able to form what scientists call cysteinyl-leukotrienes. As these biologically potent substances trigger the contraction of smooth muscle and a swelling of the airways they can cause asthma, and therefore asthma patients are often treated with drugs that block cysteinyl-leukotrienes.

"We've also found that cysteinyl-leukotrienes can stimulate the release of protein-digesting enzymes called metalloproteases, which can contribute to the weakening of the aortic wall and the development of an aneurysm," says Professor Jesper Haeggstrm, who led the study.

The researchers found that the introduction of an asthma drug blocked the cysteinyl-leukotrienes and thus impeded the release of the harmful metalloproteases. Their results suggest that this type of asthma drugs could be used to reduce aortic dilation and hence the danger of a ruptured aneurysm.

"These asthma drugs are both efficacious and safe, and we should soon be able to test any positive effect they might have on aortic aneurysm," says Professor Jesper Haeggstrm.


'/>"/>

Contact: Katarina Sternudd
katarina.sternudd@ki.se
46-852-483-895
Karolinska Institutet
Source:Eurekalert

Related medicine news :

1. Clinical trial establishes catheter-based aortic valve replacement as new standard of care
2. New treatment for severe aortic stenosis shown to save lives, Stanford researchers say
3. New Procedure for Aortic Valve Replacement Looks Promising
4. Amphetamine use increases risk of aortic tears in young adults, UT Southwestern researchers report
5. Regional protocols improve quality of care for aortic dissection patients
6. Less Invasive Fix for Abdominal Aortic Aneurysm Works
7. Research team documents benefits of endovascular stent repair for traumatic aortic injury
8. Scott & White Memorial Hospital uses device to revolutionize treatment of traumatic aortic injury
9. Oral contraceptives and hormone replacement therapy may protect women against brain aneurysms
10. Early Detection Makes a Difference in the Treatment of Brain Aneurysms
11. Cedars-Sinai study examines regional use of minimally invasive repair of aneurysms
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/9/2016)... ... December 09, 2016 , ... Flottman ... and outserts. As a means of expanding capabilities Flottman has added a ... to individually code professional inserts (PIs) and patient package inserts (PPIs) that will ...
(Date:12/9/2016)... , ... December 09, 2016 , ... An inventor from ... to safely ride all types of amusement park rides. , The patent-pending SAFETY STRAP ... is easy to use and could be set up in a matter of minutes, ...
(Date:12/9/2016)... ... December 09, 2016 , ... "I had a terrible time trying ... Va. "I thought that if the nebulizer had a more child-friendly design, then children ... , He developed the patent-pending NEBY to avoid the need to deliver medication via ...
(Date:12/8/2016)... MA (PRWEB) , ... December 08, 2016 , ... ... Workers Compensation Research Institute (WCRI) officially opened registration today for its 33rd ... Hotel in Boston, MA . , The theme of the conference is “Persistent ...
(Date:12/8/2016)... , ... December 08, 2016 , ... ... offering Medication Therapy Management (MTM), adherence, and other pharmacist-delivered patient care services, has ... general counsel and Eric Hoessel to vice president of sales. , Litsinger ...
Breaking Medicine News(10 mins):
(Date:12/9/2016)... , Dec 9, 2016 Research ... Screening Market - Forecast to 2021" report to their ... ... of open innovative models in the pharmaceutical and biotechnology industry ... and rising government funding. Emerging markets and growing research activities ...
(Date:12/9/2016)...  RxWiki Inc., a digital health company that powers ... thousands of pharmacies through its Digital Pharmacist SaaS platform, ... "50 on Fire" Award in the Health and Life ... the award as one of Austin,s fastest growing companies," ... RxWiki. "Our platform gives independent retail pharmacies the digital ...
(Date:12/9/2016)... , Dec. 9, 2016  Forge Therapeutics, ... AG (Frankfurt Stock Exchange: EVT, TecDAX, ISIN: DE0005664809) ... ,LpxC, for the treatment of bacterial infections including ... been recognized as an attractive antibacterial target for ... lack of suitable chemical starting points has hampered ...
Breaking Medicine Technology: