Navigation Links
Aortic aneurysm treatable with asthma drugs
Date:11/16/2010

A new study from the Swedish medical university Karolinska Institutet shows that asthma drugs are a potential treatment for aortic aneurysm. These drugs, which block cysteinyl-leukotrienes, could reduce the break down of vessel wall tissue and the dilation of the aortic wall, and thus the risk of its rupturing. This could both save lives and reduce the need for complicated and risky surgery. The results are presented in the scientific journal PNAS.

Aortic aneurism is a life-threatening disease caused by the weakening of a section of the wall of the aorta, which then dilates and, in advanced cases, risks rupturing. If the condition is discovered in time, surgery is a possible course of action, but often the disease develops unnoticed, causing death by sudden and massive internal haemorrhage when the aneurysm bursts.

Aortic aneurysms are more common in the 65-plus age group, and amongst men. One of the causes of the disease is a chronic inflammatory, multi-signal molecule process which activates enzymes that slowly break down proteins and the various components of the vessel wall tissue. This promotes the development of the disease and the eventual rupture of the aorta.

Researchers at Karolinska Institutet have now discovered that the wall of an aortic aneurysm contains increased levels of enzymes able to form what scientists call cysteinyl-leukotrienes. As these biologically potent substances trigger the contraction of smooth muscle and a swelling of the airways they can cause asthma, and therefore asthma patients are often treated with drugs that block cysteinyl-leukotrienes.

"We've also found that cysteinyl-leukotrienes can stimulate the release of protein-digesting enzymes called metalloproteases, which can contribute to the weakening of the aortic wall and the development of an aneurysm," says Professor Jesper Haeggstrm, who led the study.

The researchers found that the introduction of an asthma drug blocked the cysteinyl-leukotrienes and thus impeded the release of the harmful metalloproteases. Their results suggest that this type of asthma drugs could be used to reduce aortic dilation and hence the danger of a ruptured aneurysm.

"These asthma drugs are both efficacious and safe, and we should soon be able to test any positive effect they might have on aortic aneurysm," says Professor Jesper Haeggstrm.


'/>"/>

Contact: Katarina Sternudd
katarina.sternudd@ki.se
46-852-483-895
Karolinska Institutet
Source:Eurekalert

Related medicine news :

1. Clinical trial establishes catheter-based aortic valve replacement as new standard of care
2. New treatment for severe aortic stenosis shown to save lives, Stanford researchers say
3. New Procedure for Aortic Valve Replacement Looks Promising
4. Amphetamine use increases risk of aortic tears in young adults, UT Southwestern researchers report
5. Regional protocols improve quality of care for aortic dissection patients
6. Less Invasive Fix for Abdominal Aortic Aneurysm Works
7. Research team documents benefits of endovascular stent repair for traumatic aortic injury
8. Scott & White Memorial Hospital uses device to revolutionize treatment of traumatic aortic injury
9. Oral contraceptives and hormone replacement therapy may protect women against brain aneurysms
10. Early Detection Makes a Difference in the Treatment of Brain Aneurysms
11. Cedars-Sinai study examines regional use of minimally invasive repair of aneurysms
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/29/2016)... ... April 29, 2016 , ... Intellitec Solutions is ... of Microsoft Dynamics GP for one their long-term care clients. Working together with ... GP with key clinical management systems, and delivered a fully integrated accounting and ...
(Date:4/29/2016)... ... April 29, 2016 , ... Pro3rd Grunge is a package of 30 grunge-themed ... to introduce people, characters, and locations without having to set a single keyframe. Choose ... many more design components. Simply select a preset and drag it into the ...
(Date:4/29/2016)... ... April 29, 2016 , ... In its efforts of bringing quality ... its successful franchise development and expansion as it welcomes Ferdie Vasquez of the new ... experience in his 32 years of working in various industries. He had been ...
(Date:4/28/2016)... St. Petersburg, FL (PRWEB) , ... April 29, 2016 , ... Sublime Beauty® is offering ... of the same product) for 50% off. The discount is applied to the product with ... box is given to those who purchase $250 or more in products. , "So many ...
(Date:4/28/2016)... ... 28, 2016 , ... ProText Layouts is a set of 30 self-animating kinetic ... With ProText Layouts, video editors can create an energetic typography video with incredible ease. ... texts. Creating text-based videos have never been easier. , ProText Layouts includes 30 ...
Breaking Medicine News(10 mins):
(Date:4/28/2016)... 28, 2016 , Net Sales of $1.90 ... over the prior year period, and an increase of 1.2% ... Diluted EPS for the first quarter were $0.52 reported, a ... adjusted, an increase of 29.9% over the prior year period ... earnings guidance for 2016 Zimmer Biomet Holdings, Inc. ...
(Date:4/28/2016)... Calif. , April 28, 2016 /PRNewswire/ ... Validation Lifecycle Management Solutions (VLMS) today announced ... and services for sufferers of chronic kidney ... System to manage their corporate validation process. ... seeking a software solution to manage their ...
(Date:4/27/2016)... , Schweiz, April 27, 2016 ... Sachs CEO Forums in Zürich gab Strekin ... führenden Wirkstoffkandidaten STR001 zur Erhaltung des Resthörvermögens ... wurde, bekannt. Für die umfassende Phase-II-Doppelblindstudie mit ... Frankreich angeworben. STR001 wird während der Operation ...
Breaking Medicine Technology: