Navigation Links
Antiviral therapy during compensated cirrhosis most cost-effective approach
Date:5/27/2010

reated only after development of decompensated liver disease. In the third treatment strategy, patients were treated only after development of histological evidence of advanced fibrosis due to HCV recurrence post-transplantation based on annual protocol graft biopsies. The duration of therapy was deemed to be 48 weeks. Response to treatment was classified as sustained viral response (SVR) or no SVR.

The UCLA researchers conclude that the model proves treatment of patients with compensated cirrhosis is the most cost-effective strategy, resulting in improved survival and decreased cost when compared with the other strategies. Treatment of patients with decompensated cirrhosis, or those with advanced graft fibrosis due to HCV recurrence, were also found to be cost-effective, but these patients derived less survival benefit at greater cost when compared to patients treated during compensated cirrhosis.

"This study provides pharmacoeconomic evidence in support of treating HCV in patients with compensated cirrhosis before progression to more advanced liver disease, said study leader Sammy Saab, M.D. "Given the results of this study we strongly recommend expeditious administration of antiviral therapy to patients with compensated cirrhosis before their disease advances."

In an editorial in this month's issue, Marina Berenguer, M.D., while agreeing with the recommendation by Saab and colleagues, identifies flaws with the study methodology, stating, "There are clear limitations in the use of these models, mostly due to the assumptions in which they are based. The lack of subgroup analysis, the use of some unproven assumptions, and the lack of multivariate sensitivity analysis are important limitations of the model in this very complex scenario where so many variables may play an important role. Physicians must decide whether the most cost-effective approach is the most appropriate one in each individual."


'/>"/>

Contact: Dawn Peters
medicalnews@wiley.com
781-388-8408
Wiley-Blackwell
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Researchers find broad spectrum antiviral that fights multitude of viruses
2. Vaccination, antivirals and social distancing may blunt impact of H1N1 influenza
3. New Study: Improved Immune System with Gene-Eden, a Natural Antiviral Supplement that Targets Chronic Viruses
4. Targeted therapy prolongs life in patients with HER2-positive breast cancer
5. PharmMD Secures Investments to Fund New Opportunities in Medication Therapy Management
6. More smokers kick the habit with extended nicotine patch therapy, Penn research shows
7. Experts Issue Warning on Prostate Hormone Therapy
8. ASGCT: Gene Therapy Shows Promise for Patients with Pompe Disease
9. AAPM statement on quality radiation therapy
10. Congress Urged to Take Immediate Action to Ensure Frail Patients Continue to Receive Critical Therapy Services
11. Intensive Insulin Therapy Wont Boost Septic Shock Survival
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/13/2014)... Recently, 2014QuinceaneraDresses.com, the distinguished special ... new range of gorgeous Quinceanera dresses . ... for elegant Quinceanera outfits is huge. Therefore, 2014QuinceaneraDresses.com ... the company’s newly released dresses are made according ... elegant and vivid. , It is worthy ...
(Date:7/13/2014)... imaging device developed at Cedars-Sinai can provide early ... brain and are a classic sign of Alzheimer,s ... a clinical trial in Australia. , The researchers ... oral presentation at the Alzheimer,s Association International Conference ... by conference organizers to participate in a "breaking ...
(Date:7/13/2014)... 2014 Celebrity fitness trainer and former ... promotional partnership with Aqua Health Labs for their flagship ... supplement . The collaboration was recently announced live on ... trainer , actor, model, and a two time World ... celebrities, he has prepared stars including Demi Moore, Hilary ...
(Date:7/13/2014)... Seattle, Wa (PRWEB) July 13, 2014 ... updated by Vkool.com, this is a comprehensive guide that ... to deal with KP (keratosis pilaris). This ...     Chapter 1: What Is Keratosis Pilaris? ,     Chapter ... Do I Know If I Have KP? , ...
(Date:7/12/2014)... July 12, 2014 The Chicken ... the past five years, buoyed by stable demand for ... management system. “Eggs are a relatively affordable staple for ... egg consumption generally grows in line with the size ... McKitterick. Furthermore, demand for new specialty egg products with ...
Breaking Medicine News(10 mins):Health News:2014QuinceaneraDresses.com Releases Its New Quinceanera Dresses 2Health News:Study of noninvasive retinal imaging device presented at Alzheimer's conference 2Health News:Study of noninvasive retinal imaging device presented at Alzheimer's conference 3Health News:Celebrity Fitness Expert Supports Revolutionary New Health Supplement 2Health News:Living With KP Book Review Exposes Jennifer Richards' Keratosis Pilaris Guide – Vkool.com 2Health News:Living With KP Book Review Exposes Jennifer Richards' Keratosis Pilaris Guide – Vkool.com 3Health News:Chicken Egg Production in Canada Industry Market Research Report Now Available from IBISWorld 2Health News:Chicken Egg Production in Canada Industry Market Research Report Now Available from IBISWorld 3
... acoustic guitars to wounded guitar-playing service members as part of a ... in San Antonio, TX. , ... Pasadena, CA (PRWEB) ... will present over twenty new acoustic guitars to wounded guitar-playing service ...
... siRNA drug delivered systemically, FREMONT, Calif., June ... U.S. Food and Drug Administration (FDA) has,approved the ... drug candidate, DGFi, in kidney transplantation. The Company ... Delayed Graft,Function (DGF) in kidney transplant patients to ...
... at the Silicom Ventures Summit on June 29th-30th in Tel Aviv. ... ... Mind Ltd (SoM) was selected to present its concept and system for ... in Tel Aviv, Israel. The developed system, called SoM-ToUR, is based on ...
... condition a public health priority , , THURSDAY, June 26 ... kidney disease (CKD) is increasing, and the fact it raises ... public health priority, say Taiwanese researchers. , They analyzed data ... part in a standard medical screening program in 1994. The ...
... in the United States in recent years even though the ... by researchers at the Johns Hopkins Bloomberg School of Public ... percent among black men ages 25 to 44 and 12 ... is published in Online First edition of the Journal ...
... June 26 "The only way to flatten ... was the overriding,sentiment at last week,s I3 (insight, ... This statement made by keynote speaker,Wally Gomaa, president ... hospitals and employers must begin (or continue) working,together ...
Cached Medicine News:Health News:Freedom Celebration - Gibson Guitar to Provide Instruments for the Wounded 2Health News:Freedom Celebration - Gibson Guitar to Provide Instruments for the Wounded 3Health News:Quark Pharmaceuticals Receives FDA Approval of IND for Kidney Transplant siRNA Drug DGFi 2Health News:Quark Pharmaceuticals Receives FDA Approval of IND for Kidney Transplant siRNA Drug DGFi 3Health News:Step of Mind Ltd Will Present its Concept at the Silicom Ventures Summit 2Health News:Chronic Kidney Disease Growing Globally 2Health News:Researchers study hidden homicide trend 2Health News:Aegis Health Group Revealed Next Generation of Employer-Based Health-Improvement Strategies at Nashville Conference 2
(Date:7/10/2014)... 10, 2014   Ventana Medical Systems, Inc.  (Ventana), ... has entered into an agreement with Merck KGaA, Darmstadt, ... Serono in the United States ... Merck KGaA,s biopharmaceutical division on the development and commercialization ... using Ventana,s proprietary diagnostic assays. In alignment with Merck ...
(Date:7/10/2014)... Decision Resources Group finds that over half ... and Drug Administration,s (FDA) approval of Vifor Fresenius Medical ... approved by the FDA in November 2013 for the ... on dialysis. Other key findings from the ... : , Bundling: ...
(Date:1/15/2014)... Markets ( http://www.researchandmarkets.com/research/6k27gw/dental ) has announced the addition of ... Size, Share, Growth, Trends And Forecast, 2013 - 2018" ... http://photos.prnewswire.com/prnh/20130307/600769 ) Dental consumables ... to treat dental impairments, for tooth restoration and in ...
Breaking Medicine Technology:Ventana Medical Systems, Inc. and Merck KGaA, Darmstadt, Germany to develop companion diagnostic test for cancer treatment 2Ventana Medical Systems, Inc. and Merck KGaA, Darmstadt, Germany to develop companion diagnostic test for cancer treatment 3Half of Surveyed Nephrologists Report Moderate Familiarity with Velphoro, Which Received FDA Approval Late Last Year for the Treatment of Hyperphosphatemia in Dialysis 2Half of Surveyed Nephrologists Report Moderate Familiarity with Velphoro, Which Received FDA Approval Late Last Year for the Treatment of Hyperphosphatemia in Dialysis 3Dental Consumables Market - Global Industry Analysis, Size, Share, Growth, Trends And Forecast, 2013 - 2018 2Dental Consumables Market - Global Industry Analysis, Size, Share, Growth, Trends And Forecast, 2013 - 2018 3
... schools across the country, teachers are directed to send students ... have a vision issue.  This could be due to the ... the blackboard, poor performance in class or disruptive behavior. The ... difficult and that student could end up in the principal,s ...
... largest professional network for physicians, announced today ... power their medical expert searches. These firms are the ... million in honoraria to physicians last year. Using Doximity,s ... of over 30,000 physician experts. For physicians,  ...
Cached Medicine Technology:Disruptive Students May Not Be Able to See Their Problem 2Disruptive Students May Not Be Able to See Their Problem 3Disruptive Students May Not Be Able to See Their Problem 4Doximity Launches ExpertFinder to Match Clinical Need with Clinical Experts 2
... The PRIMATOM System is a multifunctional ... PRIMUS Linear Accelerator and a SOMATOM ... technology brings image guidance to radiation ... target localization within the treatment room. ...
... SOMATOM Sensation is the highly respected ... coronary branches to visualizing plaque. With its ... industrys fastest rotation time of 0.33s, virtually ... z-Sharp Technology, the system delivers unprecedented diagnostic ...
... The DGH Technology, Inc. Pachmate (DGH 55) ... 6.9 inches long and 3.6 ounces in weight. ... accurate reliable corneal thickness measurements. The Pachmate ... shirt pocket. The Pachmate is rugged in ...
... integrated system that will perform venous occlusion ... You no longer need to manually control ... with and without reactive hyperemia are included. ... for measurements and the frequency with which ...
Medicine Products: