Navigation Links
Antiviral drugs may slow Alzheimer's progression
Date:10/17/2011

Antiviral drugs used to target the herpes virus could be effective at slowing the progression of Alzheimer's disease (AD), a new study shows.

The University of Manchester scientists have previously shown that the herpes simplex virus type 1 (HSV1) is a risk factor for Alzheimer's when it is present in the brains of people who have a specific genetic risk to the disease.

AD is an incurable neurodegenerative condition affecting about 18 million people worldwide. The causes of the disease or of the abnormal protein structures seen in AD brains amyloid plaques and neurofibrillary tangles are completely unknown.

The Manchester team has established that the herpes virus causes accumulation of two key AD proteins β-amyloid (Aβ) and abnormally phosphorylated tau (P-tau) known to be the main components of plaques and tangles respectively. Both proteins are thought by many scientists to be involved in the development of the disease.

"We have found that the viral DNA in AD brains is very specifically located within amyloid plaques," said Professor Ruth Itzhaki, who led the team in the University's Faculty of Life Sciences. "This, together with the production of amyloid that the virus induces, suggests that HSV1 is a cause of toxic amyloid products and of plaques.

"Our results suggest that HSV1, together with the host genetic factor, is a major risk for AD, and that antiviral agents might be used for treating patients to slow disease progression."

Currently available antiviral agents act by targeting replication of HSV1 DNA, and so the researchers considered that they might be successful in treating AD only if the accumulation of β-amyloid and P-tau accumulation caused by the virus occurs at or after the stage at which viral DNA replication occurs.

"If these proteins are produced independently of HSV1 replication, antivirals might not be effective," said Professor Itzhaki. "We investigated th
'/>"/>

Contact: Aeron Haworth
aeron.haworth@manchester.ac.uk
44-161-275-8383
University of Manchester
Source:Eurekalert

Page: 1 2

Related medicine news :

1. UC Irvine study points to new approach to influenzas antiviral resistance
2. Arrival of direct antiviral agent therapy for hepatitis C sparks debate of who to treat first
3. Lack of health insurance limits hepatitis C patients access to latest antiviral therapy
4. New antiviral drug shows promise for dramatic improvement in hepatitis C treatment
5. Longer Antiviral Therapy Reduces Lung Transplant Complications
6. Antiviral therapy during compensated cirrhosis most cost-effective approach
7. New Study: Improved Immune System with Gene-Eden, a Natural Antiviral Supplement that Targets Chronic Viruses
8. Tests to catch the makers of dangerous legal high designer drugs
9. $8.4 million grant supports health information exchange and research on Alzheimers drugs
10. Mushroom compound appears to improve effectiveness of cancer drugs
11. Study uncovers why anti-rejection drugs for transplant patients cause hypertension
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/22/2014)... Physicians in China are most eagerly awaiting a ... lymphoma (NHL), according to a new report from ... MabThera is the only biologic available to treat diffuse ... NHL. , According to Kantar Health’s report, “Biosimilars in ... in China has been growing and is expected to ...
(Date:12/22/2014)... Super Saturday, the last Saturday before ... the busiest day in the 2014 holiday shopping season. ... had a steady pre-Christmas stream of customers, ready to ... , “I definitely intend to take advantage…of the recreational ... who was enjoying The Grass Station’s holiday sale on ...
(Date:12/22/2014)... 22, 2014 Only weeks following the ... mid-western cities to have a battery manufacturer create 29 ... ( http://www.talklocal.com ) is launching in Henderson to ... , “A strong manufacturing sector is going to build ... Singh explained, “and TalkLocal works with small businesses that ...
(Date:12/22/2014)... In recognition of Veteran’s Day, Discount Labels ... a local organization that provides services to veterans and ... on a couple hundred acres in the hills of ... class fishing, hunting, hiking, horseback riding, 4-wheeling, skeet shooting, ... ago to support U.S. Service men and women, police ...
(Date:12/22/2014)... (PRWEB) December 22, 2014 Pasadena ... offering consultations for sleep apnea. Drowsy drivers are 15 ... drivers who are well-rested, and some experts believe that ... roads as intoxicated drivers. Unfortunately, millions of Americans may ... American Academy of Sleep Medicine, about 18 million Americans ...
Breaking Medicine News(10 mins):Health News:Physicians in China See Most Significant Demand for MabThera Biosimilar 2Health News:Physicians in China See Most Significant Demand for MabThera Biosimilar 3Health News:Customers at Colorado’s Grass Station Say They’re Enjoying the Experience of Legally Purchasing Marijuana this Year to Give as Christmas Presents to Friends and Family 2Health News:TalkLocal Launches in Henderson Weeks Following New Megafactory, New Jobs Announcement 2Health News:Discount Labels Donates Portion of November Sales to Hero Reward Program 2Health News:Pasadena Dentist, Dr. Marine Martirosyan, Now Offers Consultations for Sleep Apnea 2
... adolescents and young adults finds that an extensive set ... of asthma attacks in participants who both receive care ... This finding differs from previous reports suggesting that ... future asthma attacks. These earlier conclusions, however, were based ...
... of blocking the formation of specific protein clumps that ... been discovered by researchers at the University of Pennsylvania ... they have identified drug-like inhibitors of AD tau protein ... Co-authors Alex Crowe, Research Specialist; Kurt R. ...
... , , Campaign couples power ... , HARRISBURG, Pa., Aug. 10 /PRNewswire-USNewswire/ -- ... Health Action Now campaign with a multimillion-dollar national advertising and grassroots ... dependable, affordable health insurance. The Association,s paid advertising -- available ...
... , PITTSBURGH, Aug. 10 DynaVox Mayer-Johnson, ... for individuals with speech, language and learning disabilities, today ... standard for hand-held speech solutions by bringing together comprehensive ... of mainstream communication features. , , ...
... other contact sports, study finds , MONDAY, Aug. 10 (HealthDay ... about the same rate as in baseball and football, deaths ... common in lacrosse, new research shows. , Lacrosse has swept ... making it the fastest-growing youth sport in the country. The ...
... , , HUDSON, Mass., Aug. 10 ... provider of high performance interconnect solutions for the most ... series circular connectors were selected by SynCardia Systems, Inc. ... to provide critical interconnect reliability for their Freedom(TM) driver, ...
Cached Medicine News:Health News:NIAID media availability: Still searching for predictors of asthma attacks 2Health News:New class of compounds discovered for potential Alzheimer's disease drug 2Health News:New class of compounds discovered for potential Alzheimer's disease drug 3Health News:Multimillion-Dollar AARP Campaign Busts the Myths of the Health Care Debate 2Health News:Multimillion-Dollar AARP Campaign Busts the Myths of the Health Care Debate 3Health News:DynaVox Mayer-Johnson Announces the Xpress 2Health News:DynaVox Mayer-Johnson Announces the Xpress 3Health News:Blows to the Chest Up Death Risk for Lacrosse Players 2Health News:Blows to the Chest Up Death Risk for Lacrosse Players 3Health News:Hypertronics HyperGrip(R) and D Series Connectors Selected for SynCardia's Total Artificial Heart 2
(Date:12/22/2014)... VIEJO, Calif. , Dec. 22, 2014 ... into expanded corporate offices in Aliso Viejo ... announced that due to the tremendous growth and worldwide ... needed. Sales of patented SnoreRx, the anti snore cure ... offices. He said, "We are now in 23 ...
(Date:12/22/2014)... a privately-held medical products and technologies company, today announced ... Officer of the company, effective December 22, 2014. ... Board of Directors of ConvaTec thanks Mr. Berger for ... years," said Magnus Lundberg , the Chairman of ... company is well positioned for the future."  The company ...
(Date:12/22/2014)... 2014  Mark Farrah Associates (MFA), www.markfarrah.com ... of the 2015 marketplace exchange projections and insights ... According to a recent ASPE (Office of ... of Health and Human Services) report, an estimated ... plans through the Marketplace as of October 2014 ...
Breaking Medicine Technology:ConvaTec Names Paul Moraviec Interim CEO Effective December 22, 2014 2Insights into the Marketplace and Individual Market Growth 2
... importance of dedicated information management systems for radiation ... most recent version of its MOSAIQ® Oncology Information ... Systems Society,s 2012 conference (HIMSS12), Feb. 20-24, in ... comprehensive OIS that centralizes traditional radiation oncology, particle ...
... Feb. 16, 2012  Cardium Therapeutics (NYSE Amex: ... previously announced sale of 17,857,143 shares of its common ... of approximately $5.0 million, before deducting placement agent,s fees ... investors participating in the offering purchased the shares at ...
Cached Medicine Technology:Elekta Highlights Latest Version of MOSAIQ Oncology Information System at HIMSS12 Meeting 2Cardium Announces Closing of $5.0 Million Equity Financing 2Cardium Announces Closing of $5.0 Million Equity Financing 3
Research Series 2100 Adjustable-volume Pipette,100-1,000 l, single-channel with adjustable-volume setting...
... first Sysmex hematology analyzer designed for a ... its small footprint, closed tube sampling, and ... of whole blood sample, you have a ... the emergency room, surgical suite, or small ...
... The Integrity family of pacemakers ... and truly automatic devices in today's ... combination of automated features and diagnostic ... popular and proven Affinity pacemakers platform. ...
... PT System is an in vitro diagnostic ... results, expressed in seconds and INR units. ... It is intended for use by health ... to monitor patients who are on warfarin-type ...
Medicine Products: