Navigation Links
Antipsychotic Drug Boosts Risk of Heart Disease, Diabetes
Date:4/7/2008

French study in rats finds olanzapine changes metabolism in weeks

MONDAY, April 7 (HealthDay News) -- Use of the antipsychotic medication olanzapine may put a person at an increased risk for heart disease and type 2 diabetes, new findings show.

A team of French researchers studying the drug's effect on male rats found that, after consuming olanzapine over several weeks, the rodents' blood sugar levels rose significantly compared to rats not on the drug. This was especially noticeable after the rats ate meals with glucose in them. The rats consuming olanzapine did not gain weight or increase their food intake; however, the proportion of fat stored in their abdominal cavity was notably higher.

These changes are increased risk factors of metabolic syndrome, which puts an individual at greater risk of heart disease and type 2 diabetes.

"Based on these findings, we concluded that male rats treated with olanzapine experienced an early disruption of energy metabolism. This was a result of the fat tissue we observed and the impairment in blood sugar regulation which are both associated with metabolic syndrome and subsequent risk of diabetes," senior study author Dominique Hermier, of the Department of Human Nutrition, INRA, in Paris, said in a prepared statement.

The study was to be presented Monday at the Experimental Biology annual meeting, in San Diego.

Olanzapine is a part of the second generation of antipsychotics known as atypical antipsychotics being used to treat schizophrenia. These newer medicines have proven as effective as their predecessors in treating the delusions and hallucinations that accompany psychotic mental illness and even more effective in combating other symptoms, such as apathy. Side effects, though, include weight gain and a greater chance for developing metabolic syndrome. Physicians fear these side effects may cause their patients to stop taking their medicine.

"Atypical medications like olanzapine are of tremendous value in treating individuals with certain kinds of mental illness. Our hope is that through discoveries such as this one, such life-enhancing medicines can be further optimized," Hermier said.

More information

The American Heart Association has more about metabolic syndrome.



-- Kevin McKeever



SOURCE: American Physiological Society, news release, April 7, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Antipsychotic Drugs of Little Benefit to Alzheimers Patients
2. Comparison of antipsychotic treatments in adolescents with schizophrenia
3. Weight gain induced by antipsychotic drugs can be avoided
4. Some antipsychotic drugs may be missing their mark
5. Antidepressant as Good as Antipsychotics for Dementia
6. Investigational Agent Targeting Metabotropic Glutamate 2/3 Receptors Demonstrates Antipsychotic Activity in Humans, Study in Nature Medicine Finds
7. Green Tea Boosts Antibiotics for Superbugs
8. Abdominal Fat Boosts Dementia Risk
9. Artery Plaque Boosts Hispanics Odds for Stroke
10. Stopping a receptor called nogo boosts the synapses
11. New Method Boosts Cardiac Arrest Survival
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/20/2017)... ... September 20, 2017 , ... ... a voice for people who have kidney disease. The theme “Describe a positive ... their stories. Entrants needed to meet only one qualification— to have been ...
(Date:9/20/2017)... D.C. (PRWEB) , ... September 20, 2017 , ... ... join the roster of exhibitors at the East-coast edition of MarTech: The Marketing ... MarTech Boston will bring together more than 40 speakers — representing such ...
(Date:9/20/2017)... ... September 20, 2017 , ... Each year ... the National Athletic Trainers’ Association Annual Clinical Symposium and Expo. New research is ... also when Athletic Trainers are acknowledged by their peers with accolades and highly ...
(Date:9/20/2017)... ... ... The Centers for Medicare and Medicaid Services (CMS) stated in the Inpatient Prospective ... S-10 to distribute Disproportionate Share Hospital (DSH) Uncompensated Care Payments over the next two ... October 17, 2017 at 2 P.M. EST and uncover how you can prepare for ...
(Date:9/20/2017)... ... ... “The Trials I Face to Receive God’s Grace”: a mesmerizing take on ... to better one’s life through God. “The Trials I Face to Receive God’s Grace” ... places, found a love for writing. Green feels that expressing his feelings through prayer ...
Breaking Medicine News(10 mins):
(Date:9/9/2017)... Dealmed Medical Supplies, New York ... supplies, drugs, vaccines, and specialty medical products and services, ... to acquire Vantage Medical Supplies, a major distributor of ... New York . ... medical practices, will operate under the Dealmed name as ...
(Date:9/7/2017)... Caris Life Sciences, a leading innovator ... of precision medicine, today announced results from two ... molecular profiling approach in guiding therapeutic strategies in ... (CGP+) with Caris Molecular Intelligence ® to ... level, leading to more therapeutic options and improved ...
(Date:9/6/2017)... -- Robert G. Szewc, M.D., is recognized by Continental Who,s ... his contributions to the Medical field.      ... practice of Kidney and Hypertension Specialists, which specializes in ... He has worked in this position since 2002, and ... as expertise in kidneys, hypertension, chronic disease and anemia, ...
Breaking Medicine Technology: