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Antipodean Pharmaceuticals Announces Results of Phase 2 Study of Lead Compound MitoQ(R)
Date:4/24/2008

the progression of NAFLD through to NASH, leading to fibrosis or cirrhosis.

About Non-alcoholic Fatty Liver Disease (NAFLD)

Symptoms of NAFLD include inflammation of the liver, often associated with alcoholic livers, but occurring in nonalcoholic patients, fat in the liver and liver damage. As with Hepatitis C, oxidative stress is involved in disease progression in NAFLD, which affects approximately 20% of the world's population.

There are no satisfactory treatment options currently available for NAFLD, and the incidence is growing rapidly as obesity rates rise. MitoQ(R) is a potent, targeted antioxidant that limits oxidative stress and cell degeneration by protecting the mitochondria from oxidative damage, and the Company believes it offers the potential to treat the oxidative stress observed in NAFLD patients.

About Antipodean

Antipodean is a clinical-stage pharmaceutical company developing targeted molecules that prevent oxidative damage to endothelial, epithelial and liver cells leading to apoptosis and fibrosis. The Company is developing a mitochondria-targeted antioxidant, MitoQ (mitoquinone mesylate), for the treatment of hepatic inflammatory disorders caused by oxidative stress such as nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH). The Company's business plan is to develop drugs to the point of proof of principle and then partner further development. Antipodean has research collaborations with pre-clinical and clinical investigators in Cambridge, UK, Auckland, New Zealand, and several centers in the US to identify and develop lead compounds through to clinical proof-of-principle. Currently the Company's lead compounds target liver and skin diseases. Antipodean is located in San Francisco, California. Further information is available at http://www.antipodeanpharma.com


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SOURCE Antipodean Pharmaceuticals, Inc.
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