Navigation Links
Antiplatelets: 1 person, 1 dose?
Date:4/14/2011

Montreal, April 14, 2011 An international consortium of scientists, including major contributions from the Montreal Heart Institute, demonstrates that the "one-size fits all" strategy of uniformly doubling the dose of an antiplatelet drug, clopidogrel, for patients with high on-treatment platelet reactivity does not reduce the incidence on death, heart attacks and stent thrombosis after percutaneous coronary intervention (PCI). The results of the GRAVITAS trial conducted to determine whether high-dose clopidogrel is superior to standard-dose therapy for the prevention of cardiovascular events after percutaneous coronary intervention in patients with high on-treatment reactivity, have been published recently in the Journal of the American Medical Association.

The GRAVITAS (Gauging Responsiveness with A VerifyNow assay Impact on Thrombosis And Safety) study showed no benefit of double-dose compared with standard-dose clopidogrel and the results refute the strategy of uniformly doubling the dose of clopidogrel over six months for patients with high on-treatment platelet reactivity after PCI with drug-eluting stent. In the multicenter, randomized, double-blind, active-control trial, the use of high-dose compared with standard-dose clopidogrel did not reduce the incidence of adverse cardiac events such as death, nonfatal myocardial infarction or stent thrombosis.

"The results of GRAVITAS are surprising because they do not support a uniform treatment strategy of high-dose clopidogrel in patients with high on-treatment reactivity." said Dr. Jean-Franois Tanguay, interventional cardiologist at the Montreal Heart Institute, professor of medicine at the Universit de Montral and lead investigator in Canada. "Personalized medicine merits further investigation. We need to assess alternative treatment strategies incorporating platelet function testing as opposed to prescribe a fixed, higher dose."

Between July 2008 and April 2010, 2214 patients from 83 sites in North America had high on-treatment reactivity after being screened with platelet function testing 12 to 24 hours after PCI. They were randomly assigned to either higher (double-dose) or standard-dose clopidogrel for six months after drug-eluting stent implantation. An additional 586 patients without high on-treatment reactivity were selected at random and assigned to treatment with standard-dose clopidogrel. Clopidogrel exposure prior to enrollment was similar across all 3 treatment groups.

At six months, the rate of death from cardiovascular causes, nonfatal myocardial infarction or stent thrombosis was not different with high-dose (25 of 1109 patients) compared with standard-dose (25 of 1105 patients) clopidogrel in patients with high on-treatment reactivity. ''These low event rates reflect the excellent results we can obtain with drug-eluting stents'' said Dr. Tanguay.


'/>"/>

Contact: Julie Chevrette
julie.chevrette@icm-mhi.org
514-376-3330 x2641
Montreal Heart Institute
Source:Eurekalert

Related medicine news :

1. Drug addicts get hooked via prescriptions, keep using to feel like a better person, research shows
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/2/2016)... ... May 02, 2016 , ... “Engineering Bubbles,” an oil painting submitted by Canadian ... Forum held recently at the Annual Meeting in Los Angeles. The first annual art ... members and Annual Meeting attendees. , “Through art I hope to educate people ...
(Date:5/2/2016)... ... May 02, 2016 , ... WestHarbor Growth Partners, ... today the release of Grow Healthy Vending’s newly revamped brand campaign. Grow ... growing healthy vending providers in North America with locations across the United States ...
(Date:5/2/2016)... ... 2016 , ... East Los Angeles dentist , Dr. Ramin Assili, is ... to receive any dental extraction treatment for $40 off the regular price. This promotion ... the lower price, patients can more easily afford extractions to eliminate teeth that are ...
(Date:5/2/2016)... , ... May 02, 2016 , ... Further establishing itself ... announce that the new WHIMZEES Variety Value Boxes were selected from over 1,000 entrants ... Showcase Award. , WHIMZEES natural dental chews for dogs are a favorite product ...
(Date:5/2/2016)... , ... May 02, 2016 , ... ... itself around major organs, such as the kidneys, liver and pancreas. If not ... M.D ., a board-certified physician in Internal Medicine, Medical Oncology and Palliative Care, ...
Breaking Medicine News(10 mins):
(Date:5/2/2016)... MARLBOROUGH, Mass. , May 2, 2016  While ... effects that osteoporosis can have on their health, only ... 1   according to the results of a new ... ). To mark the start of National Osteoporosis Month, ... women,s health, which affects nearly 56 million Americans. ...
(Date:5/2/2016)... , May 2, 2016 ... to reach USD 11.1 billion by 2024, according ... Research, Inc. Major drivers of the sonography market ... areas and government recommendations for periodic ultrasound screenings ...      (Logo: http://photos.prnewswire.com/prnh/20150105/723757 ) ...
(Date:4/29/2016)... April 29, 2016 ReportsnReports.com ... 2016" market research report that provides an overview ... analysis at various stages, therapeutics assessment by drug ... (RoA) and molecule type, along with latest updates, ... reviews key players involved in the therapeutic development ...
Breaking Medicine Technology: