Navigation Links
Antioxidants show no clear benefit against cardiovascular events, death in high-risk women
Date:8/13/2007

Vitamins C and E and beta carotene, either individually or in combination, do not appear to reduce the risk of cardiovascular events or death among women at high risk for heart disease, according to a report in the August 13/27 issue of Archives of Internal Medicine, one of the JAMA/Archives journals.

Oxidative damageharm to cells caused by exposure to oxygenmay contribute to the development of cardiovascular disease, according to background information in the article. In addition, compounds known as free radicals may damage artery linings, encourage blood clots and alter the function of blood vessels. Antioxidants scavenge free radicals and limit the damage they can cause, the authors write. Diets high in fruit and vegetable intake, and thus rich in such antioxidants, have been associated with reduced rates of coronary heart disease and stroke. Vitamins C and E and beta carotene are potential mediators of the apparent protective effect of a plant-based diet on cardiovascular disease.

Nancy R. Cook, Sc.D., of Brigham & Womens Hospital and Harvard Medical School, Boston, and colleagues tested the effects of these compounds in the Womens Antioxidant Cardiovascular Study, which followed 8,171 women 40 years or older (average age 60.6) beginning in 1995 to 1996. The women, who either had a history of cardiovascular disease or three or more risk factors, were randomly assigned to take 500 milligrams of ascorbic acid (vitamin C) or placebo every day; 600 international units of vitamin E or placebo every other day; and 50 milligrams of beta carotene or placebo every other day. Participants were followed up for the occurrence of heart events (including stroke, heart attack and bypass surgery) or death through 2005.

During the average study period of 9.4 years, 1,450 women had one or more cardiovascular events, including 274 heart attacks, 298 strokes, 889 coronary revascularization procedures (bypass surgery or angioplasty) and 395 cardiovascular deaths (out of a total 995 deaths). There was no overall effect of ascorbic acid, vitamin E or beta carotene on the primary combined end point or on the individual secondary outcomes of myocardial infarction, stroke, coronary revascularization or cardiovascular disease death, the authors write. There were no significant interactions between agents for the primary end point, but those randomized to both active ascorbic acid and vitamin E experienced fewer strokes.

No additional adverse effects were observed for those taking active pills vs. placebo, with the exception of a small increase in reports of upset stomach among those taking active beta carotene.

Overall, we found no benefit on the primary combined end point for any of the antioxidant agents tested, alone or in combination, the authors conclude. We also found no evidence for harm. While additional research into combinations of agents, particularly for stroke, may be of interest, widespread use of these individual agents for cardiovascular protection does not appear warranted.
'/>"/>

Contact: Lori J. Shanks
617-534-1600
JAMA and Archives Journals
Source:Eurekalert

Related medicine news :

1. Antioxidants protect health tissue in people undergoing radiation therapy.
2. Antioxidants found in chocolates
3. Antioxidants used for longevity
4. Antioxidants found in chocolates
5. Herbs: rich soure of antioxidants
6. Herbs: rich soure of antioxidants
7. Sweet corn releases antioxidants on cooking
8. The Use Of Antioxidants To Diminish Effects of Alcohol During Pregnancy Questioned
9. Commercial grape juices and vinegars found rich in antioxidants
10. Antioxidants in the body protects the airways from diesel exhaust effect
11. Fruit And Vegetable Peels Are Rich Source Of Potent Antioxidants
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/3/2016)... Los Angeles, CA (PRWEB) , ... May 03, 2016 , ... ... Massage Chair with its user friendly Samsung tablet and exclusive Smart Application. The ... truly unbeatable massage. Starting each massage with a customized user profile and specialized massage ...
(Date:5/3/2016)... ... 03, 2016 , ... Intrigma, the leading provider of vital ... expanding its use of Intrigma’s cloud-based physician scheduling solution, Efficient Scheduler (a part ... The Portland, Oregon based health system conducted a one-year pilot of the Efficient ...
(Date:5/3/2016)... ... May 03, 2016 , ... Octo ... solutions and digital consulting services to the federal government, has been awarded a ... / Indefinite Quantity (ID/IQ) contract in support of the U.S. Army Program Executive ...
(Date:5/3/2016)... CA (PRWEB) , ... May 03, 2016 , ... ... a special type of surgical procedure that can be used to diagnose and treat ... instruments can be inserted. These instruments include a special lighting system and lens that ...
(Date:5/3/2016)... ... 2016 , ... Branches, Inc. is proud to have been selected as a ... in South Miami. Macy’s is a wonderful community partner and has helped to support ... mentoring, enrichment and academic support to elementary students 5 days a week. Summer Shade, ...
Breaking Medicine News(10 mins):
(Date:5/2/2016)... May 2, 2016  Deerfield announced today it ... Graybug Vision, Inc. Graybug Vision is an early ... may transform care for ocular diseases including wet ... technology was first developed at Johns Hopkins University ... venture. Graybug Vision is developing ...
(Date:5/2/2016)... , May 2, 2016 ... to reach USD 11.1 billion by 2024, according ... Research, Inc. Major drivers of the sonography market ... areas and government recommendations for periodic ultrasound screenings ...      (Logo: http://photos.prnewswire.com/prnh/20150105/723757 ) ...
(Date:4/29/2016)... New Jersey , April 29, 2016 /PRNewswire/ ... Software Suite for Life Sciences, Product Development Capabilities ... Global Life Science Customer Base . ... solutions provider, today announced the acquisition of Skura ... a global leader in adaptive sales enablement technology ...
Breaking Medicine Technology: