Navigation Links
Antioxidants offer pain relief in patients with chronic pancreatitis
Date:12/31/2008

Bethesda, MD (Jan. 1, 2009) Antioxidant supplementation was found to be effective in relieving pain and reducing levels of oxidative stress in patients with chronic pancreatitis (CP), reports a new study in Gastroenterology. CP is a progressive inflammatory disease of the pancreas in which patients experience abdominal pain (in early stage) and diabetes and maldigestion (in late stage). Pain is the major problem in 90 percent of patients with CP and currently, there is no effective medical therapy for pain relief. Gastroenterology is the official journal of the American Gastroenterological Association (AGA) Institute.

In this placebo-controlled, double blind trial, 127 patients, ages 30.5+/-10.5, were assigned to placebo or antioxidant groups. After six months, the reduction in the number of painful days/month was significantly higher in the antioxidant group, compared with the placebo group (7.46.8 versus 3.24, respectively). The reduction in the number of analgesic tablets/month was also higher in the antioxidant group (10.511.8 versus 4.45.8, respectively). Furthermore, 32 percent and 13 percent of patients became pain free in the antioxidant and placebo groups, respectively; the beneficial effect of antioxidants on pain relief was noted early at three months.

"Abdominal pain, the predominant symptom in patients with CP, is difficult to treat. The main reason for a largely ineffective medical treatment is that the mechanism of pain in CP is not well understood," said Pramod Kumar Garg, MD, DM, of the All India Institute of Medical Sciences, New Delhi and lead author of the study. "We are encouraged by our findings, as significant improvement was noted with antioxidants in respect to all the parameters of pain in this study. In addition, reduction in pain resulted in fewer man-days lost, thus providing functional employment gain to the patients. The findings should spur further research in this exciting area."

There are two important implications of this study the fact that measures of oxidative stress were increased initially and decreased subsequently after supplementation with antioxidants suggests that there is a state of heightened free radical mediated injury in CP, and that injury is reversible. Second, with regard to pain management, this trial showed that antioxidant therapy is effective for pain relief in patients with CP. This assumes significance since no effective medical therapy exists for pain relief for such patients.

Pancreatitis is inflammation of the pancreas that usually begins as a sudden attack and is often caused by gallstones, alcohol abuse or genetic mutations. Symptoms of pancreatitis start with a gradual or sudden severe pain in the center part of the upper abdomen going through to the back. Treatment often focuses on the nutritional and metabolic needs of the patient and on relieving pain. Most people with chronic pancreatitis have a good prognosis if they follow their treatment regimen. "Aside from medication, abstaining from alcohol and smoking are most important and key to halt the progression of CP," added Dr. Garg.

Visit www.gastro.org/patient for more patient information about pancreatitis.


'/>"/>

Contact: Alissa J. Cruz
media@gastro.org
301-272-1603
American Gastroenterological Association
Source:Eurekalert

Related medicine news :

1. Antioxidants show no clear benefit against cardiovascular events, death in high-risk women
2. New research into plant colors sheds light on antioxidants
3. Antioxidants do not prevent degenerative eye disease
4. Citrus juice, vitamin C give staying power to green tea antioxidants
5. Natural Antioxidants Help Reduce Oxidative Stress in Diabetes Treatment
6. Citrus Juice Gives Boost to Green Tea Antioxidants
7. Alimera Sciences Signs Second Agreement With Emory University for Potential Treatments Using New Class of Antioxidants
8. Dr. William S. Gruss, M.D., Says That Medical Research Shows You Can Reduce Your Risk of Cancer By Up To 77% and Reverse the Effects of Aging in A CARDIOLOGISTS GUIDE TO ... ANTI-AGING, ANTIOXIDANTS & RESVERATROL
9. Cancer Patients Should Steer Clear of Antioxidants
10. Too Much Sun, Too Few Antioxidants Spell Eye Trouble
11. Coromega Unveils New Healthy Heart and CoQ10 Supplements : Revolutionary Omega-3 Supplement Company Introduces Two Fresh Takes on Heart Health and Antioxidants
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/6/2016)... ... December 06, 2016 , ... Of the variety of ingredients in ... hot dog. But contrary to common beliefs that hot dogs include “everything but the ... on the package. Ingredients combined with meat and poultry in a hot dog recipe ...
(Date:12/6/2016)... ... 06, 2016 , ... The NALA, a boutique marketing agency, is proud to ... (TBCF), a nonprofit 501(C)(3) organization providing financial and emotional support to families of children ... TBCF, the NALA recently hosted a Thanksgiving food drive that resulted in four boxes ...
(Date:12/6/2016)... , ... December 06, 2016 , ... ... Center with an Award of Distinction, recognizing the organization as a top behavioral ... excel in the areas of clinical quality, staff satisfaction and qualifications, and consumer ...
(Date:12/6/2016)... ... December 06, 2016 , ... ... in research and development, largely due to its potential for revolutionizing human disease ... (hMSCs) and human induced pluripotent stem cells (hiPSCs). , Both platforms have ...
(Date:12/6/2016)... ... 06, 2016 , ... METTLER TOLEDO has launched its online ... white papers, guides, handbooks, case studies, magazines, webinars, videos, catalogs, brochures, datasheets, user ... documents, webinars and videos available online, visit the METTLER TOLEDO Expertise Library ...
Breaking Medicine News(10 mins):
(Date:12/5/2016)... , Dec. 5, 2016   Mallinckrodt Pharmaceuticals ... specialty pharmaceutical company, today announced that it received a ... Equality Index (CEI), a national benchmarking survey and report ... bisexual and transgender (LGBT) workplace equality, administered by the ... of 517 major U.S. businesses which also earned top ...
(Date:12/5/2016)... INTRODUCTION Since the ... as a crucial class of pharmacological interventions responsible ... are also used for prophylactic purposes in patients ... patients undergoing chemotherapy). However, the inappropriate use of ... rapidly accelerated an evolutionary response of antibiotic drug ...
(Date:12/5/2016)... Special purpose needles are used in target specific drug deliveries ... organs or lumps and are available in the market with ... special purpose needles is showing a steady growth owing to ... special purpose needles market is projected to expand at a ... expected to be valued at US$ 17,261.5 million by the ...
Breaking Medicine Technology: