Navigation Links
Antioxidant supplements may lessen benefit of radiation and chemotherapy
Date:5/27/2008

Cancer patients should avoid the routine use of antioxidant supplements during radiation and chemotherapy because the supplements may reduce the anticancer benefits of therapy, researchers concluded in a commentary published online May 27 in the Journal of the National Cancer Institute.

Radiation and many chemotherapy agents work to kill cells by inducing free radicals that damage DNA and proteins. Therefore, there is a possibility that taking antioxidant supplements, such as vitamin E or -carotene, may interfere with the therapies and reduce their anticancer activity. On the other hand, some investigators hypothesize that antioxidant supplementation may protect healthy tissues and reduce the side effects of treatment. Despite two decades of research into this question, no clear answer has appeared.

To evaluate the potential harms or benefits of antioxidant supplementation, Brian D. Lawenda, M.D., of the Naval Medical Center San Diego and colleagues reviewed all of the randomized trials they could identify that tested the effect of antioxidant supplements on radiation therapy or chemotherapy.

In the case of radiotherapy, they identified nine studies that addressed the question, including two meta-analyses. However, only three studies were randomized controlled trials designed to look at the clinical effect of antioxidant therapy on radiation. In the largest of the randomized trials, antioxidant supplementation was associated with a reduction in overall survival. One antioxidant agent, amifostine, which is already approved by the U.S. Food and Drug Administration to increase radioresistance in healthy salivary gland tissues, may protect normal tissues without increasing tumor radioresistance. Lawenda and colleagues caution that the question needs to be studied further before a solid conclusion can be made.

The authors identified 16 randomized controlled trials that examined the impact of antioxidant supplementation on chemotherapy. Six of the trials were placebo-controlled.

Of the studies that included information on response rates, none reported a decrease in response in the antioxidant arm of the trial compared with the control arm. However, Lawenda and colleagues caution that none of the trials was large enough to reliably detect such differences.

Despite some intriguing studies that have suggested the benefit of adjunctive antioxidant treatments in cancer patients, the totality of the available evidence is equivocal at best and leaves us with serious concerns about the potential for harm, the authors write.


'/>"/>

Contact: Liz Savage
jncimedia@oxfordjournals.org
301-841-1287
Journal of the National Cancer Institute
Source:Eurekalert

Related medicine news :

1. Antioxidants show no clear benefit against cardiovascular events, death in high-risk women
2. Antioxidant Supplements May Raise Womens Skin Cancer Risk
3. New research into plant colors sheds light on antioxidants
4. Antioxidants do not prevent degenerative eye disease
5. Major ORAC Differences Among Top Antioxidant Beverages
6. Grape Consumption Improves Antioxidant Capacity in Humans
7. Snapples New Antioxidant Water and LYTeWater Take Hydration to the Next Level
8. Citrus juice, vitamin C give staying power to green tea antioxidants
9. Natural Antioxidants Help Reduce Oxidative Stress in Diabetes Treatment
10. New Research Confirms Wild Blueberry Antioxidant Power
11. Citrus Juice Gives Boost to Green Tea Antioxidants
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/23/2017)... ... June 24, 2017 , ... Studies show evidence that ... the risk of visual loss in these patients. , But how often do ophthalmologists ... smoking cessation to patients at risk of or with early symptoms of AMD? A ...
(Date:6/23/2017)... ... June 23, 2017 , ... Everybody has their own personal preference when it ... it, and some people don't like it at all. FindaTopDoc took a look at ... Erotic literature can give readers a taste of their deepest, darkest fantasies and has ...
(Date:6/23/2017)... , ... June 23, 2017 , ... ... Cancer Conference from Sept. 18 to 20. , The two-day conference is focused ... with the goal of improving patients’ lives and eliminating racial breast cancer-related disparities. ...
(Date:6/23/2017)... ... June 23, 2017 , ... Ross Insurance Agency ( ... Federal Emergency Management Agency’s (FEMA) recent update of flood zones, more people than ... Biggert-Waters Act was enacted to reflect the actual risk in flood zone areas ...
(Date:6/23/2017)... ... June 23, 2017 , ... Jusino Insurance Services, a ... in the greater Chicago metropolitan area, is embarking on a charity drive in ... Chicago. , Founded in 1897, Hephzibah Children’s Association is one of the oldest ...
Breaking Medicine News(10 mins):
(Date:6/1/2017)... BELL, Pa. , June 1, 2017 ... (PRN) and Veterinarian Recommended Solutions (VRS), and KD Pharma ... investment in Nutriceutical Holdings by KD Pharma Group. KD ... Holdings with the option to acquire the entire company. ... partner in KD. They are committed to growing the ...
(Date:5/29/2017)... May 29, 2017  Cellect Biotechnology Ltd. (NASDAQ: ... which enables the functional selection of stem cells, today ... the first quarter ended March 31 st , 2017. ... accomplishments in the first quarter of 2017," said Dr. ... we announced the treatment of the first blood cancer ...
(Date:5/23/2017)... , May 23, 2017  Leaf Healthcare, recognized ... medical devices for pressure ulcer prevention, will unveil ... Association of Critical Care Nurses, National Teaching Institute ... The Leaf Patient Monitoring System is ... the hospital environment.  The system seamlessly tracks patient ...
Breaking Medicine Technology: