Navigation Links
Antioxidant may prevent alcohol-induced liver disease
Date:5/2/2011

BIRMINGHAM, Ala. An antioxidant may prevent damage to the liver caused by excessive alcohol, according to new research from the University of Alabama at Birmingham. The findings, published online April 21, 2011, in the journal Hepatology, may point the way to treatments to reverse steatosis, or fatty deposits in the liver that can lead to cirrhosis and cancer.

The research team, led by Victor Darley-Usmar, Ph.D., professor of pathology at UAB, introduced an antioxidant called mitochondria-targeted ubiquinone, or MitoQ, to the mitochondria of rats that were given alcohol every day for five to six weeks in an amount sufficient to mirror excessive intake in a human.

Chronic alcoholics, those who drink to excess every day, experience a buildup of fat in the liver cells. When alcohol is metabolized in the liver, it creates free radicals that damage mitochondria in the liver cells and prevent them from using sufficient amounts of oxygen to produce energy. Moreover, the low-oxygen condition called hypoxia worsens mitochondrial damage and promotes the formation of the fatty deposits that can progress to cirrhosis.

Darley-Usmar and his collaborators say that the antioxidant MitoQ is able to intercept and neutralize free radicals before they can damage the mitochondria, preventing the cascade of effects that ultimately leads to steatosis.

"There has not been a promising pharmaceutical approach to preventing or reversing the long-term damage associated with fatty deposits in the liver that result from excessive consumption of alcohol," said Darley-Usmar. "Our findings suggest that MitoQ might be a useful agent for treating the liver damage caused by prolonged, habitual alcohol use."

"Previous studies have shown that MitoQ can be safely administered long-term to humans," said Balu Chacko, Ph.D., a research associate and co-author of the study. "As it has been shown to decrease liver damage in hepatitis C patients, it ma
'/>"/>

Contact: Bob Shepard
bshep@uab.edu
205-934-8934
University of Alabama at Birmingham
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Antioxidants in pecans may contribute to heart health and disease prevention
2. Weizmann Institute scientists discover: Antioxidants cause fertility problems in females
3. Organic onions, carrots and potatoes do not have higher levels of healthful antioxidants
4. Antioxidants may help prevent malaria complicaton that leads to learning impairment
5. New Mario Badescu Skin Care Product Combines Moisture, Sun Protection, and Antioxidants
6. High doses of antioxidant supplements induce stem cell genetic abnormalities
7. Cloves are the best natural antioxidant
8. COPPERTONE(R) Solar Research Center Unveils Studies on Efficacy of Topical Antioxidants in Sunscreens at 2010 Annual Meeting of The American Academy of Dermatology
9. ENERCA clinical recommendations for sickle cell disease management and prevention in children
10. Parents have role in smoking prevention
11. Aspirins Clot-Prevention Ability Blunted by Dietary Fat: Study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/22/2014)... Angeles, CA (PRWEB) December 22, 2014 ... reputable PALS, BLS and ACLS online certification provider, are ... http://www.acls-pals-bls.com . The updated site now features a ... easier than ever to use. , As a ... peoples’ information is now consolidated into a single page ...
(Date:12/22/2014)... U.S. and state health officials are investigating a listeria ... least four people and sickened 28 others in 10 ... prepackaged caramel apples until more information becomes available, the ... a news release. As of Dec. 18, a ... outbreak strains of the bacteria Listeria monocytogenes . ...
(Date:12/22/2014)... 22, 2014 Super Saturday, the last ... year as the busiest day in the 2014 holiday ... Grass Station had a steady pre-Christmas stream of customers, ... past Saturday. , “I definitely intend to take advantage…of ... Denver resident who was enjoying The Grass Station’s holiday ...
(Date:12/22/2014)... recognition of Veteran’s Day, Discount Labels contributed a portion ... that provides services to veterans and their families, free ... hundred acres in the hills of Southern Indiana, the ... hiking, horseback riding, 4-wheeling, skeet shooting, and much more. ... U.S. Service men and women, police officers, fire fighters ...
(Date:12/22/2014)... (PRWEB) December 22, 2014 7,178 small ... bustle of Black Friday shopping and opted instead to ... marketing education company, for their 5th annual “Black Friday ... charged just $7 to attend the 5 hour online ... they promptly donated to support two Central Texas based ...
Breaking Medicine News(10 mins):Health News:ACLS Online Certification Website ACLS-PALS-BLS.com Now Features a New and User-Friendly Layout 2Health News:CDC Warns of Listeria Danger From Caramel Apples 2Health News:Customers at Colorado’s Grass Station Say They’re Enjoying the Experience of Legally Purchasing Marijuana this Year to Give as Christmas Presents to Friends and Family 2Health News:Discount Labels Donates Portion of November Sales to Hero Reward Program 2Health News:Austin Company Digital Marketer Raises 100K to Fight Childhood Cancer 2Health News:Austin Company Digital Marketer Raises 100K to Fight Childhood Cancer 3
... , The partnership will bridge diabetes ... ORLANDO, Fla., Aug. 17 Florida Hospital and Burnham ... giant step in advancing Orlando as a hub for medical ... together to announce the appointment of Dr. Steven R. Smith, ...
... , MILWAUKEE, Aug. 17 ... the top performing health system in the country in a national ... initiative. This is the second consecutive year that Aurora has ... Demonstration project that involves 250 hospitals from across the country. , ...
... study finds small stature not a problem , , MONDAY, ... their short child will be psychologically damaged from merciless teasing, ... no lasting effects from any exposure to short jokes. , ... Pediatrics , found that short children reported being teased only ...
... , , , ... the incidence of skin cancer at a time when melanoma rates ... the Women,s Dermatologic Society (WDS ) will offer free skin ... ages at the world-class LPGA Solheim Cup and the PING Junior ...
... It’s not ... hold. Dr. Jack P. Gunter and his elite team of cosmetic specialists are giving patients ... best for that particular patient after cosmetic enhancement procedures before they even set foot inside ... (Vocus) ...
... ... ... one of the nation,s largest providers of specialty products and services for the workers, compensation market, ... , , ,"We are excited to have Lori join PMSI in this critical role. She is ...
Cached Medicine News:Health News:Florida Hospital and Burnham Institute Announce New Executive Director and Facility for Clinical Research Institute 2Health News:Florida Hospital and Burnham Institute Announce New Executive Director and Facility for Clinical Research Institute 3Health News:Aurora Health Care Top Performing Health System in National Quality Initiative 2Health News:Aurora Health Care Top Performing Health System in National Quality Initiative 3Health News:Aurora Health Care Top Performing Health System in National Quality Initiative 4Health News:For Short Kids, No Lack of Self-Esteem 2Health News:For Short Kids, No Lack of Self-Esteem 3Health News:Illinois Dermatologists Tee Up for Sun Safety at Two World-Class Golf Championships 2Health News:Dr. Jack P. Gunter Offers 3D Imaging for Dallas, Texas Plastic Surgery Patients 2Health News:Dr. Jack P. Gunter Offers 3D Imaging for Dallas, Texas Plastic Surgery Patients 3Health News:Dr. Jack P. Gunter Offers 3D Imaging for Dallas, Texas Plastic Surgery Patients 4Health News:PMSI Appoints Lori Daugherty as President of Pharmacy Division 2
(Date:12/19/2014)... --Research and Markets ( http://www.researchandmarkets.com/research/942kh3/micro_market ) ... Market Monitor: North American Dermatology Diagnostic Devices Market" ... http://photos.prnewswire.com/prnh/20130307/600769 Cosmetic surgeries ... resulted in fueling the overall demand of the ... these dermatology devices is to assist in identifying ...
(Date:12/19/2014)... -- Capnia, Inc. (NASDAQ: CAPN ), ... on its proprietary Sensalyze™ Technology Platform for precision ... for the third quarter and nine months ended ... of our initial public offering (IPO), we are ... CoSense® commercial launch," said Anish Bhatnagar, M.D., Chief ...
(Date:12/19/2014)... Since last month,s FBI shutdown of online drug marketplace ... online black market for illegal drugs - Evolution Marketplace ... drugs and other illegal items.  New numbers from the ... lowering the numbers of drugs and illegal items available ... But some new sites that have emerged as potentially ...
Breaking Medicine Technology:Micro Market Monitor: North American Dermatology Diagnostic Devices Market 2Micro Market Monitor: North American Dermatology Diagnostic Devices Market 3Capnia Reports Third Quarter 2014 Financial Results 2Capnia Reports Third Quarter 2014 Financial Results 3Capnia Reports Third Quarter 2014 Financial Results 4Capnia Reports Third Quarter 2014 Financial Results 5Capnia Reports Third Quarter 2014 Financial Results 6Capnia Reports Third Quarter 2014 Financial Results 7Capnia Reports Third Quarter 2014 Financial Results 8Post Silk Road - Another Online Drug Den Now Dominates the DarkNet 2Post Silk Road - Another Online Drug Den Now Dominates the DarkNet 3
Pediatric size. Loops retract lids. Polished finish....
Open ring design with shaft angled at 45 degrees. Blunt teeth. Round knurled handle with dull finish....
Fixation ring with atraumatic teeth provides excellent stabilization and pressure on globe. Round knurled handle with dull finish....
... Designed to fixate the eye ... two-sided ring can easily be ... or smooth side on the ... to the eye to increase ...
Medicine Products: