Navigation Links
Antineoplastic agents associated with thyroid dysfunction
Date:10/18/2011

Antineoplastic agents such as immunotherapies and targeted therapies that specifically target signaling pathways in cancer cells are associated with thyroid dysfunction in 20%-50% of cancer patients taking them, which can adversely affect patients' quality of life, according to a study published Oct. 18 in the Journal of the National Cancer Institute.

Over the past two decades, novel antineoplastic agents have been introduced that inhibit specific cellular processes to limit cancer cell growth. Some of these agents cause thyroid dysfunction, which physicians often overlook because of the complexity of the clinical picture in cancer patients. The symptoms of thyroid dysfunction, such as fatigue, weakness, depression, memory loss, and cardiovascular effects can be wrongly attributed to the primary disease. If under-diagnosed, thyroid dysfunction can adversely affect a patient's quality of life.

To understand the thyroid-related side effects of antineoplastic agents, their frequency, and underlying mechanisms, Ole-Petter Riksfjord Hamnvik, M.D., of the Division of Endocrinology, Diabetes, and Hypertension at Brigham and Women's Hospital in Boston, and colleagues reviewed articles on thyroid dysfunction in cancer patients. The researchers found that there are no known strategies to prevent thyroid disease in patients receiving these new antineoplastic agents, and that possible preventative measures may be more toxic than the thyroid disease itself. They also say that screening for thyroid disease is likely beneficial, but note that there were no screening recommendations for asymptomatic patients in the literature they reviewed. However, in this review, the authors provide their own recommendations for patients based on the pattern of abnormalities with each agent, in addition to recommending the monitoring of thyroid function tests in clinical trials of antineoplastic agents.

The researchers also recommend several paths of res
'/>"/>

Contact: Zack Rathner
jncimedia@oxfordjournals.org
301-841-1286
Journal of the National Cancer Institute
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Professional Insurance Agents to Hold 2010 Federal Legislative Summit March 17-18
2. Long Term Care Insurance Leader Seeks 320 New Agents in 2010, Following Strong 2009 Growth
3. Professional Insurance Agents Name Rep. Charlie Melancon 2010 Legislator of the Year
4. Health Insurance Agents Work with Zane Benefits to Offer New Solutions amid Health Care Reform
5. Mayo-led research team develop agents that keep insulin working longer
6. Study provides molecular rationale for combining targeted agents to treat breast cancer
7. VCU Massey first to combine targeted agents to kill multiple myeloma cells
8. Improved protocols for contrast agents eliminates new cases of nephrogenic systemic fibrosis
9. Turning agents of disease into tools for health and better living
10. New anti-cancer agents show promise for treating aggressive breast cancers
11. Imaging agents offer new view of inflammation, cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/27/2015)... Mountain View, CA (PRWEB) May 27, 2015 ... Napa Valley will be able to reach for Organic Coconut ... 2015. Coco Libre will be available at VIP areas, artist ... will also be available at area hotels and on festival ... as a partner this year,” said Noa Elan, Director of ...
(Date:5/27/2015)... 27, 2015 Genius Monkey is pleased ... programmatic marketing technology, they have boosted sales for the ... a regional level for seven Utah-based dealers. , ... television and radio media. In 2014 the Utah Honda ... of Genius Monkey , shifted their marketing campaigns ...
(Date:5/27/2015)... May 27, 2015 With a prevalently ... poll conducted during the "ACA - Controlling the Chaos" ... 75% are currently in the process of researching ... were confidently prepared for the reporting mandates. , According ... the webinar, those who are currently vetting ACA reporting ...
(Date:5/27/2015)... Portland, Oregon (PRWEB) May 27, 2015 ... treatments in North America, is offering free design advice ... the outside environment. , “Light pollution caused by ... can cause a restless night’s sleep, said Kim Rush, ... residents of numerous cities across North America with recently ...
(Date:5/27/2015)... Louisville, KY (PRWEB) May 27, 2015 ... or worse because of lack of compliance documentation or ... a recycler in Miami, a propane gas company in ... doling out fines for incidents and accidents due to ... System (LMS) is proud to introduce the new ...
Breaking Medicine News(10 mins):Health News:Coco Libre Puts Organic Coconut Water on the Line-up at BottleRock Napa 2Health News:Genius Monkey Boosts Utah Honda Dealers Website Traffic 142% 2Health News:Employers are On Track for ACA Reporting According to Businessolver Poll 2Health News:Decorview Helps Homeowners Combat Light Pollution 2Health News:New Supervisor Feature Streamlines HR Compliance Reporting and Documentation 2Health News:New Supervisor Feature Streamlines HR Compliance Reporting and Documentation 3
... That Indicate Egg Quality and QuantityPRINCETON, N.J., April 6 ... buy at retail, a new test that can help ... pregnant. The First Response(R) Fertility Test for Women is ... stimulating hormone (FSH) levels to evaluate ovarian reserve - ...
... N.J., April 6 The following was released today by Dystonia ... Wicke d & the ... a Caus e - Anthony Galde of Wicke ... 2nd Annual Curtain Call for a Cause on behalf of dystonia, ...
... Rheumatoid arthritis (RA) is a systemic disease or an ... joints through the thin layer of cells called the synovium ... of RA are swollen joints and crippling stiffness, particularly of ... of appetite and also impedes mobility and quality of life. ...
... - a first-of-its-kind training program to help refractive & cataract surgeons ... boot camp session will be held on June 5th in Chicago ... ... April 6, 2009 -- Premium Lens Boot Camp™ - a first-of-its-kind ...
... inspired to start an internet weblog about health. Dr. Davon Jacobson, ... and truth on various health topics. , ... Greenwich, ... a general practitioner and establishing a private medical practice, Dr. Davon ...
... web-based delivery of clinical data enable community hospital staff ... April 5 Siemens ( ... its MedSeries4 Clinical Suite enterprise-wide solution, which ... access vital clinical data in three clicks or less. ...
Cached Medicine News:Health News:Video: New First Response(R) Fertility Test Helps Women Answer the Question: Am I Able to Get Pregnant? 2Health News:Video: New First Response(R) Fertility Test Helps Women Answer the Question: Am I Able to Get Pregnant? 3Health News:Video: New First Response(R) Fertility Test Helps Women Answer the Question: Am I Able to Get Pregnant? 4Health News:Broadway Comes to New Jersey 2Health News:Rheumatoid Arthritis Therapeutics in Thailand 2Health News:Rheumatoid Arthritis Therapeutics in Thailand 3Health News:Premium Lens Boot Camp™ Helps Refractive Surgeons Grow Their Premium IOL Practice 2Health News:Medical Doctor Enhances Health Awareness through Online Blogging 2Health News:Community Hospitals Remain Competitive with Latest Enhancement to Siemens' MedSeries4 Clinical Suite 2Health News:Community Hospitals Remain Competitive with Latest Enhancement to Siemens' MedSeries4 Clinical Suite 3Health News:Community Hospitals Remain Competitive with Latest Enhancement to Siemens' MedSeries4 Clinical Suite 4
(Date:5/27/2015)... 27, 2015  The 2015 LiftWalker, developed by ... Systems Corporation ball drive actuator to give the ... the industry,s largest selection of electromechanical linear actuators ... of industries, including medical devices. ... wheelchair-bound as well as people who just need ...
(Date:5/27/2015)... -- Medical Device Contract Manufacturing - new ... Where is the market for medical ... prospects for this market and medical device ... shows you potential revenues and other trends to 2025, ... page report provides 127 tables, charts, and graphs. Discover ...
(Date:5/27/2015)... , May 27, 2015 In a ... Canadian International Pharmacy Association (CIPA) found ... from licensed Canadian pharmacies. Approximately 64% of respondents purchase ... from a non-U.S. pharmacy due to costs of ... covered under their insurance plan.   Many ...
Breaking Medicine Technology:Innovative Technology Liberates the Wheelchair-Bound 2Medical Device Contract Manufacturing Market Forecast 2015-2025 2Medical Device Contract Manufacturing Market Forecast 2015-2025 3Medical Device Contract Manufacturing Market Forecast 2015-2025 4Medical Device Contract Manufacturing Market Forecast 2015-2025 5Medical Device Contract Manufacturing Market Forecast 2015-2025 6Medical Device Contract Manufacturing Market Forecast 2015-2025 7Canadian International Pharmacy Association (CIPA) Survey of Americans Finds 64% Purchase Medications from Canada Due to Affordability 2Canadian International Pharmacy Association (CIPA) Survey of Americans Finds 64% Purchase Medications from Canada Due to Affordability 3
... Sept. 17 Biodel Inc. (Nasdaq: BIOD ) ... board of directors.  Mr. Urciuoli is chairman of ArcherGroup, a ... to the board of the newly-formed Kroll Bond Rating Agency. ... former director of Kroll, Inc.  He spent 30 years at ...
... 16 Alere Inc. (NYSE: ALR ) announced ... of senior subordinated notes due 2018, it entered into a ... September 15, 2010.  The size of the offering was increased ... coupon of 8.625% and are being offered at 100.0% of ...
Cached Medicine Technology:Biodel Appoints Arthur Urciuoli to its Board of Directors 2Biodel Appoints Arthur Urciuoli to its Board of Directors 3Alere Inc. Announces Pricing of Senior Subordinated Notes Offering; Offering Size Increased to $400.0 Million 2
The VascoTip J 9/60 PU is a unipolar tined, J-preformed permanent pacing lead. Due to advanced technology, VascoTip J 9/60 PU M is compatible to all pacemaker-cavities with the size of IS-1 (3.2 mm),...
Steroid-eluting, screw-in pacing lead...
... one of the world's thinnest, ... a 7 F introducer, the ... designed to lower the incidence ... introduction in smaller, more tortuous ...
Tendril DX active-fixation leads allows for lower thresholds initially and during the lead maturation phase....
Medicine Products: