Navigation Links
Antineoplastic agents associated with thyroid dysfunction
Date:10/18/2011

Antineoplastic agents such as immunotherapies and targeted therapies that specifically target signaling pathways in cancer cells are associated with thyroid dysfunction in 20%-50% of cancer patients taking them, which can adversely affect patients' quality of life, according to a study published Oct. 18 in the Journal of the National Cancer Institute.

Over the past two decades, novel antineoplastic agents have been introduced that inhibit specific cellular processes to limit cancer cell growth. Some of these agents cause thyroid dysfunction, which physicians often overlook because of the complexity of the clinical picture in cancer patients. The symptoms of thyroid dysfunction, such as fatigue, weakness, depression, memory loss, and cardiovascular effects can be wrongly attributed to the primary disease. If under-diagnosed, thyroid dysfunction can adversely affect a patient's quality of life.

To understand the thyroid-related side effects of antineoplastic agents, their frequency, and underlying mechanisms, Ole-Petter Riksfjord Hamnvik, M.D., of the Division of Endocrinology, Diabetes, and Hypertension at Brigham and Women's Hospital in Boston, and colleagues reviewed articles on thyroid dysfunction in cancer patients. The researchers found that there are no known strategies to prevent thyroid disease in patients receiving these new antineoplastic agents, and that possible preventative measures may be more toxic than the thyroid disease itself. They also say that screening for thyroid disease is likely beneficial, but note that there were no screening recommendations for asymptomatic patients in the literature they reviewed. However, in this review, the authors provide their own recommendations for patients based on the pattern of abnormalities with each agent, in addition to recommending the monitoring of thyroid function tests in clinical trials of antineoplastic agents.

The researchers also recommend several paths of res
'/>"/>

Contact: Zack Rathner
jncimedia@oxfordjournals.org
301-841-1286
Journal of the National Cancer Institute
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Professional Insurance Agents to Hold 2010 Federal Legislative Summit March 17-18
2. Long Term Care Insurance Leader Seeks 320 New Agents in 2010, Following Strong 2009 Growth
3. Professional Insurance Agents Name Rep. Charlie Melancon 2010 Legislator of the Year
4. Health Insurance Agents Work with Zane Benefits to Offer New Solutions amid Health Care Reform
5. Mayo-led research team develop agents that keep insulin working longer
6. Study provides molecular rationale for combining targeted agents to treat breast cancer
7. VCU Massey first to combine targeted agents to kill multiple myeloma cells
8. Improved protocols for contrast agents eliminates new cases of nephrogenic systemic fibrosis
9. Turning agents of disease into tools for health and better living
10. New anti-cancer agents show promise for treating aggressive breast cancers
11. Imaging agents offer new view of inflammation, cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... (PRWEB) January 22, 2015 Carinsurancesavings.biz has released ... accidental death and dismemberment insurance . , Purchasing an ... can be very advantageous. This type of rider provides benefits ... dismemberment can be considered a lesser form of life insurance. ...
(Date:1/22/2015)... January 22, 2015 A study ... Medicine flagship journal Medicine & Science in Sports ... exercise may help reduce gastrointestinal (GI) problems associated ... , Participants in the double-blind, placebo-controlled study took ...
(Date:1/22/2015)... (PRWEB) January 23, 2015 Recently, Weddingshe.com has ... catalog, and has announced its highest annual revenues in the ... on its popular glamorous wedding dresses. , According to the ... important wedding dress promotions for them in 2015. This point ...
(Date:1/22/2015)... 22, 2015 Four years since the release of ... coincided with the marriage of Avasa & Matthew Love – the ... is scheduled for release through White Swan Records on February 24, ... is a sacred path available to all of us to walk ...
(Date:1/22/2015)... EBSCO Information Services (EBSCO) and the ... in an effort to further promote visibility and adoption of ... long made AMA journals available via its subscription services, EBSCO ... Network. , Long known as both a subscription ...
Breaking Medicine News(10 mins):Health News:Accidental Death and Dismemberment Insurance Can Be Purchased at Low Prices Online 2Health News:Study Shows Kyowa Hakko’s L-Citrulline May Help Reduce Gastrointestinal Injury During Strenuous Exercise 2Health News:Study Shows Kyowa Hakko’s L-Citrulline May Help Reduce Gastrointestinal Injury During Strenuous Exercise 3Health News:Weddingshe Announces A Special Offer On Its Popular Glamorous Wedding Dresses 2Health News:THE ROAD by Avasa & Matthew Love -- A New Album 2Health News:THE ROAD by Avasa & Matthew Love -- A New Album 3Health News:THE ROAD by Avasa & Matthew Love -- A New Album 4Health News:EBSCO Expands Partnership with the American Medical Association 2Health News:EBSCO Expands Partnership with the American Medical Association 3Health News:EBSCO Expands Partnership with the American Medical Association 4
... compound that gives curry powder its yellow/orange color, may inhibit ... neck cancer who continue to smoke. In a paper ... and Neck Surgery Foundation (AAO-HNSF) Annual Meeting & OTO EXPO ... head and neck squamous cell carcinoma (HNSCC) growths. The study ...
... CA Patients who suffer from chronic rhinosinusitis (CRS) ... asthma, hypertension, and arthritis. In a paper ... Head and Neck Surgery Foundation (AAO-HNSF) Annual Meeting & ... records of 1,970,695 patients to determine whether there was ...
... million babies are born preterm, almost 10 percent of total ... estimated 13 million infants worldwide are born premature each year ... first month of life, according to a report released Sunday. ... and for 28 percent of newborn deaths, the data ...
... ... Day , ... Africa (Vocus) October 4, 2009 -- Four-year-old Celine was born with congenital cataracts in both ... afford the $180 (US) for surgery for each eye, plus the money required for hospital ...
... Oct. 3 Mercedes-Benz donates an R320 BlueTEC clean ... Hope & Healing in Lewiston, Maine during the inaugural ... in the safety and comfort of transporting those receiving ... , The Patrick Dempsey Center for Cancer Hope & ...
... O,Brien, president of Catholics for Choice, issued the following statement ... Conference of Catholic Bishops holds its annual Respect Life Sunday. ... bishops to also respect the truth. A recent publication by ... recent polls on healthcare reform prove that the bishops, desire ...
Cached Medicine News:Health News:1 Million 'Preemie' Babies Die Each Year: Report 2Health News:1 Million 'Preemie' Babies Die Each Year: Report 3Health News:Mercy Ships Surgeon Addresses Blindness Through Sutureless Technique 2Health News:Mercy Ships Surgeon Addresses Blindness Through Sutureless Technique 3Health News:Mercy Ships Surgeon Addresses Blindness Through Sutureless Technique 4Health News:Mercedes-Benz Gives to a McDreamy Cause 2Health News:Mercedes-Benz Gives to a McDreamy Cause 3Health News:Mercedes-Benz Gives to a McDreamy Cause 4Health News:Respect Life and the Truth on Respect Life Sunday 2Health News:Respect Life and the Truth on Respect Life Sunday 3
(Date:1/23/2015)... , January 23, 2015 Heptares Therapeutics, ... delighted to announce that the Malcolm Campbell Memorial ... (Vice President of Chemistry), Fiona Marshall (Chief ... Executive Officer and co-founder) for the seminal contributions to GPCR ...
(Date:1/22/2015)... UPI ), a medical device company that ... voiding dysfunctions, today reported financial results for the fiscal ... revenue for the Company,s Urgent ®  PC Neuromodulation System ... record, as compared to $3.9 million in the third ...
(Date:1/22/2015)...  Bio-Techne Corporation (NASDAQ: TECH ) announced today ... the new Simple Plex platform through its Proteins Platform ... re-branding of the previously acquired CyPlex instrument platform from ... transformative immunoassay technology which integrates an innovatively designed microfluidic ...
Breaking Medicine Technology:Heptares Scientists to Receive the Malcolm Campbell Memorial Prize for 2015 in Recognition of Their Outstanding Contribution to GPCR Drug Discovery 2Heptares Scientists to Receive the Malcolm Campbell Memorial Prize for 2015 in Recognition of Their Outstanding Contribution to GPCR Drug Discovery 3Heptares Scientists to Receive the Malcolm Campbell Memorial Prize for 2015 in Recognition of Their Outstanding Contribution to GPCR Drug Discovery 4Uroplasty Reports Record Revenue in Fiscal Third Quarter 2Uroplasty Reports Record Revenue in Fiscal Third Quarter 3Uroplasty Reports Record Revenue in Fiscal Third Quarter 4Uroplasty Reports Record Revenue in Fiscal Third Quarter 5Uroplasty Reports Record Revenue in Fiscal Third Quarter 6Uroplasty Reports Record Revenue in Fiscal Third Quarter 7Uroplasty Reports Record Revenue in Fiscal Third Quarter 8Uroplasty Reports Record Revenue in Fiscal Third Quarter 9Uroplasty Reports Record Revenue in Fiscal Third Quarter 10Uroplasty Reports Record Revenue in Fiscal Third Quarter 11Uroplasty Reports Record Revenue in Fiscal Third Quarter 12Uroplasty Reports Record Revenue in Fiscal Third Quarter 13Uroplasty Reports Record Revenue in Fiscal Third Quarter 14Uroplasty Reports Record Revenue in Fiscal Third Quarter 15Uroplasty Reports Record Revenue in Fiscal Third Quarter 16Uroplasty Reports Record Revenue in Fiscal Third Quarter 17Uroplasty Reports Record Revenue in Fiscal Third Quarter 18Bio-Techne Launches Simple Plex Platform 2Bio-Techne Launches Simple Plex Platform 3
... growing medical-surgical supply costs as reimbursements shrink and healthcare ... spending immediately—and GHX is providing a list of what ... it. The healthcare technology company released its list at ... focus on documented opportunities for cutting what has become ...
... June 27, 2011 Auxogyn, Inc., a privately held ... announced that the U.S. Patent and Trademark Office (USPTO) ... the assessment of embryo viability during in vitro ... viability assessment (Eeva™) System. "This patent ...
Cached Medicine Technology:Top 10 Ways to Cut Medical-Surgical Supply Spending Now 2Top 10 Ways to Cut Medical-Surgical Supply Spending Now 3Auxogyn Announces Issuance of Key Patent Covering Predictive Embryo Assessment Parameters for In Vitro Fertilization 2
... is a rapid and accurate bedside test for ... the diagnosis and assessment of patients with suspected ... speed and accuracy profit from a test ... = 12 minutes. In emergency departments Point of ...
Intermittent catheter...
... dimension in vitreoretinal surgery. ,By using ... purified perfluoro-n-octane, you can greatly expand ... for managing retinal detachments complicated by ... trauma. , ,Certified to be >99.9 ...
Disease diagnosis and treatment reference sourced from Griffith's 5-Minute Clinical Consult. Save time diagnosing and treating more than 1,200 diseases and conditions....
Medicine Products: