Navigation Links
Antifungal drug delays need for chemo in advanced prostate cancer
Date:6/2/2011

f worsening disease was measured by a 25 percent increase in their blood level of prostate specific antigen (PSA), a marker for prostate cancer.

Early in the trial, preliminary analysis of 17 men receiving low doses of itraconazole showed that only two of them (11.8 percent) had stable or declining PSA. Because of the limited response, no further men were given low doses of the drug.

However, 11 of 24 (48.4 percent) men taking high doses of itraconazole had stable or declining PSA levels lasting at least 24 weeks. In addition, nearly a third of men taking the high dose had PSA reductions of 30 percent or more. Metastatic prostate cancer patients receiving no treatment typically would worsen in eight to 12 weeks, according to Antonarakis.

The investigators also found that 12 of 14 men taking high doses of itraconazole had lower levels of circulating tumor cells present in their blood after therapy, compared with their baseline levels.

Seven patients experienced side effects, including low potassium, hypertension and fluid retention, but the problems were resolved with potassium replacement pills, anti-hypertension drugs, and diuretics.

"We also tested whether itraconazole acted as hormone therapy by tracking levels of testosterone and DHEA (a testosterone derivative) in the blood, and we found no reductions of either testosterone or DHEA," says Antonarakis. "This finding shows that itraconazole is not just another hormone therapy, and has a unique mechanism of action."

Antonarakis and colleagues next plan to examine blood and skin samples taken from study participants specifically to look for levels of proteins linked to tumor blood vessel formation and the Hedgehog pathway.

"With these results, we believe that high-dose itraconazole is worth studying in a larger group of men with advanced prostate cancer," adds Antonarakis.


'/>"/>

Contact: Vanessa Wasta
wasta@jhmi.edu
410-955-1287
Johns Hopkins Medical Institutions
Source:Eurekalert

Page: 1 2

Related medicine news :

1. New Research Uncovers Elusive Target of Antifungal Agent
2. Flat Head Syndrome Linked to Developmental Delays
3. New study reveals long delays and variability are losing the UK research and jobs
4. In brain-injured children, early gesturing predicts language delays
5. Drug that restricts blood supply to prostate tumors delays disease progression
6. Deaths From Heart Attack Rise With Delays in Care
7. Phase III study shows everolimus delays tumor progression in hard-to-treat neuroendocrine tumors
8. Bilingualism delays onset of Alzheimers symptoms
9. Delivery Even a Bit Early May Mean Developmental Delays
10. Heart Patients With Depression Often Find ER Delays
11. Blood Pressure Drug Delays Kidney Disease in Diabetics
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/3/2015)... Angeles, CA (PRWEB) , ... August 03, 2015 , ... According to an opinion ... calories out of person’s diet leads to one pound of weight loss may not be ... caloric reduction that translates to one pound of fat varies – based both on the ...
(Date:8/3/2015)... Princeton, NJ (PRWEB) , ... August 03, 2015 ... ... named a finalist in 2015 MarketingProfs Bright Bulb B2B Awards. , The MarketingProfs ... by and for B2B brands. BESLER Consulting's campaign for the launch of their ...
(Date:8/3/2015)... CA (PRWEB) , ... August 03, 2015 , ... ... Hispanic Health notes that while an overwhelming number of Hispanics believe people ... , The overwhelming 70 percent of participants queried said making diet changes was ...
(Date:8/3/2015)... ... August 03, 2015 , ... Social impact organization’s #HelpOneHelpMany ... 2015 – Since winning a South by Southwest® (SXSW®) Interactive Innovation Award in ... whose mission is to develop technology for the sake of humanity – continues ...
(Date:8/3/2015)... ... ... AxoGen, Inc. (NASDAQ: AXGN), a leader in developing and marketing innovative surgical solutions ... Wednesday, August 12, 2015 at 9:45am (ET) at Le Parker Meridien in New York, ... be accessed via the investor relations section of the Company’s website. , About AxoGen, ...
Breaking Medicine News(10 mins):Health News:Article Dispelling Weight Loss Myth Correctly Emphasizes the Complicated and Difficult Nature of Weight Loss, Says Dr. Michael Feiz 2Health News:Hispanics More Likely to Struggle with Misinformation About Diabetes 2Health News:Hispanics More Likely to Struggle with Misinformation About Diabetes 3Health News:Hispanics More Likely to Struggle with Misinformation About Diabetes 4Health News:Not Impossible Earns Top Awards for Technologies Benefiting Humanity 2Health News:Not Impossible Earns Top Awards for Technologies Benefiting Humanity 3Health News:Not Impossible Earns Top Awards for Technologies Benefiting Humanity 4Health News:AxoGen, Inc. to Present at the Wedbush Healthcare Conference 2
... Goal of 40 million doses by end of October won,t ... -- Production delays continue to hamper distribution of the H1N1 ... , The vaccine is growing more slowly in egg-based cultures ... this time, Dr. Thomas R. Frieden, director of the U.S. ...
... heart patients when ARB added to ACE inhibitor therapy, study ... angiotensin receptor blocker (ARB) drug to help control blood pressure ... are taking an ACE inhibitor, a new study finds. , ... therapy seems no better than ACE inhibitor therapy alone and ...
... lower-than-normal levels of a naturally-occurring fat hormone may increase ... the blood which claims thousands of lives each year. ... Hospital and the University of Toronto focused on adiponectin, ... organs. The findings were presented this week at the ...
... new Commonwealth Fund report analyzes the similarities, differences, potential ... five committees of jurisdiction in the United States Congress: ... Committees in the Senate and the U.S. House of ... and Commerce committees. The report, Provisions of Comprehensive ...
... research finds that mother,s drug use affects male offspring,s behavior ... monkeys exposed to cocaine in the womb have poor impulse ... research has found. , The male monkeys continued to have ... risk factor for drug abuse, said the researchers, who added ...
... More than half the people who take antidepressants for depression ... depression has been oversimplified and drugs designed to treat it ... the Northwestern University Feinberg School of Medicine. The medications are ... eye instead of the center. A study from ...
Cached Medicine News:Health News:Swine Flu Vaccine Still in Short Supply 2Health News:Swine Flu Vaccine Still in Short Supply 3Health News:Adding Drug Doesn't Help Control Blood Pressure 2Health News:Canadian scientists link fat hormone to death from potentially deadly blood infection 2Health News:Analysis of Congressional health reform bills highlights similarities, differences, costs 2Health News:Cocaine Use in Pregnancy Linked to Impulsivity in Sons 2Health News:Why antidepressants don't work for so many 2Health News:Why antidepressants don't work for so many 3
(Date:8/3/2015)... August 3, 2015 Global ... to reach USD 24.7 billion by 2022, according ... Inc. Growing prevalence of neurological and musculoskeletal disorders ... over the forecast period. The presence of efficient ... advancement in the technologies coupled with implementation of ...
(Date:8/3/2015)... RADNOR, Pa. , Aug. 3, 2015 ... of laboratory products, services and solutions, announces the redesign of ... its customers. When visiting the new site, ... site with bold colors and vivid images.  Each country site ... , an A to Z product menu; and , ...
(Date:8/3/2015)... 3, 2015  BioElectronics Corporation (OTC Pink: BIEL), maker ... that Andrew J. Whelan , President will be ... "On Business" at 9am EDT on Wednesday, August 5 ... to: http://tunein.com/radio/Money-Matters-Boston-1120-s27548/ ... acceptance the company,s flagship product, ActiPatch Therapy, is achieving ...
Breaking Medicine Technology:Physiotherapy Equipments Market Worth $24.7 Billion By 2022: Grand View Research, Inc. 2Physiotherapy Equipments Market Worth $24.7 Billion By 2022: Grand View Research, Inc. 3Physiotherapy Equipments Market Worth $24.7 Billion By 2022: Grand View Research, Inc. 4Physiotherapy Equipments Market Worth $24.7 Billion By 2022: Grand View Research, Inc. 5VWR's New Website Redesign Provides Improved Functionality for Customers 2UpTick News Wire Radio Show Will Interview BioElectronics' CEO Andrew Whelan 2
... Reportlinker.com announces that a new market research report ... Colorectal Cancer - France Drug Forecasts and Treatment ... Colorectal Cancer - France ... SummaryGlobalData, the industry analysis specialist, has ...
... West Booth# 19112 -- In anticipation of SupplySide West ... that it has entered into a strategic agreement with Mantrose-Haeuser ... distribution of its HIDROX® products, used in dietary supplement and ... "We are looking at the market for dietary supplements and ...
Cached Medicine Technology:Reportlinker Adds Colorectal Cancer - France Drug Forecasts and Treatment Analysis to 2020 2Reportlinker Adds Colorectal Cancer - France Drug Forecasts and Treatment Analysis to 2020 3Reportlinker Adds Colorectal Cancer - France Drug Forecasts and Treatment Analysis to 2020 4Reportlinker Adds Colorectal Cancer - France Drug Forecasts and Treatment Analysis to 2020 5Reportlinker Adds Colorectal Cancer - France Drug Forecasts and Treatment Analysis to 2020 6Reportlinker Adds Colorectal Cancer - France Drug Forecasts and Treatment Analysis to 2020 7Reportlinker Adds Colorectal Cancer - France Drug Forecasts and Treatment Analysis to 2020 8Reportlinker Adds Colorectal Cancer - France Drug Forecasts and Treatment Analysis to 2020 9Reportlinker Adds Colorectal Cancer - France Drug Forecasts and Treatment Analysis to 2020 10Reportlinker Adds Colorectal Cancer - France Drug Forecasts and Treatment Analysis to 2020 11Reportlinker Adds Colorectal Cancer - France Drug Forecasts and Treatment Analysis to 2020 12Reportlinker Adds Colorectal Cancer - France Drug Forecasts and Treatment Analysis to 2020 13Reportlinker Adds Colorectal Cancer - France Drug Forecasts and Treatment Analysis to 2020 14Reportlinker Adds Colorectal Cancer - France Drug Forecasts and Treatment Analysis to 2020 15CREAGRI Partners With Mantrose-Haeuser Co., Inc. for the Distribution of Its HIDROX® 2CREAGRI Partners With Mantrose-Haeuser Co., Inc. for the Distribution of Its HIDROX® 3
Bechert-McPherson tying forceps, angled, 10 mm tying platforms....
Shepard tying forceps, round curved platform 8 mm, 8.5 cm....
Girard curved tying forceps made of titanium has curved shafts with 8 mm tying platforms, width of shafts 0,25 mm, TCI platforms, round handle, diam. 6 mm, overall length 99 mm....
Girard straight tying forceps made of titanium has straight shafts with 6 mm tying platforms, width of shafts 0,25 mm, TCI platforms, round handle, diam. 6 mm, overall length 105 mm....
Medicine Products: