Antidepressants that are more efficient ...(he UPV/EHU and is currently carrying out...),Health
he UPV/EHU and is currently carrying out research in the pharmacological laboratory at the University.
Greater braking effect than normal
What this study proposes is, on the one hand, to make advances in our knowledge about a highly prevalent illness depression - which is still largely of unknown etiology and, on the other, to develop treatment strategies that are more efficacious than the current ones.
Depression is mainly related to disorders with or deficiencies of the neurotransmitters, noradrenaline and serotonine. In the process of depression, the levels of noradrenaline and serotonine in a number of cerebral areas are altered. The task of anti-depressive drugs is to balance, as it were, these levels. However, the biggest drawback in the current treatment of this illness is that only 60-70% of patients respond to treatment. Moreover, when a person starts to be treated, they normally require at least between two and four weeks before symptoms begin to improve and, on not observing any type of short-term improvement, many stop taking the medication.
Due to this, the aim of this PhD was to study the action mechanisms of these drugs in order to, on the one hand, identify treatments that act from the start and, on the other, try to improve the situation for patients who in principle do not respond to this treatment.
To this end, the usual treatments are combined with new targets the antagonist pharmaceutical drugs of the adrenoceptors α2 that help to boost or increase neurotransmission existing in the brain. Given that it has been observed that in post-mortem brains of patients previously diagnosed with depression and who had committed suicide, these adrenoceptors were found to be altered, their function increased and there was a greater braking effect than normal. This braking impeded the neurotransmission systems from functioning correctly. If we stop this greater braking effect in those persons suffering depr
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