Navigation Links
Antidepressants that are more efficient and faster
Date:2/4/2008

In the PhD defended by the pharmacologist and biochemist Jorge Emilio Ortega Calvo at the University of the Basque Country, a new anti-depressant treatment strategy is proposed that is capable of improving on the current one with its drawbacks.

Depression is a chronic and recurrent illness that can affect at least 20% of the population at some period in their lifetime, according to a number of studies carried out. Moreover, according to the WHO, by 2020 emotional state disorders could be the foremost or second cause for sick leave from work in the developed countries. Current ant-depressive therapies, nevertheless, are far from optimum.

This was the theme of the PhD presented by the pharmacologist and biochemist from the Basque province of Gipuzkoa, Jorge Emilio Ortega Calvo, undertaken at the Faculty of Medicine and Odontology of the University of the Basque Country (UPV/EHU). Basically it was a study in which an analysis was undertaken of the action mechanisms of current antidepressant pharmacological drugs and new antidepressant treatment strategies put forward and that could be useful in the near future in order to address the failings in the current ones.

The PhD entitled, Nuevas estrategias de potenciacin antidepresiva basadas en la interaccin entre los sistemas noradrenrgico y serotonrgico centrales. Estudio mediante microdilisis cerebral in vivo (New strategies of antidepressive boosting based on the interaction between the central noradrenergic and serotonergic systems. A study using in vivo cerebral microdialysis) was directed by Professor of Pharmacology, Jos Javier Meana Martnez and lecturer in Pharmacology, Luis Felipe Callado Hernando, and which obtained excellent cum laude. While carrying out the PhD, Mr Ortega had the opportunity to spend time at a pharmaceutical multinational in the United States, concretely at the Eli Lilly Laboratories.

Jorge Emilio Ortega Calvo graduated in Pharmacy and Biochemistry from the UPV/EHU and is currently carrying out research in the pharmacological laboratory at the University.

Greater braking effect than normal

What this study proposes is, on the one hand, to make advances in our knowledge about a highly prevalent illness depression - which is still largely of unknown etiology and, on the other, to develop treatment strategies that are more efficacious than the current ones.

Depression is mainly related to disorders with or deficiencies of the neurotransmitters, noradrenaline and serotonine. In the process of depression, the levels of noradrenaline and serotonine in a number of cerebral areas are altered. The task of anti-depressive drugs is to balance, as it were, these levels. However, the biggest drawback in the current treatment of this illness is that only 60-70% of patients respond to treatment. Moreover, when a person starts to be treated, they normally require at least between two and four weeks before symptoms begin to improve and, on not observing any type of short-term improvement, many stop taking the medication.

Due to this, the aim of this PhD was to study the action mechanisms of these drugs in order to, on the one hand, identify treatments that act from the start and, on the other, try to improve the situation for patients who in principle do not respond to this treatment.

To this end, the usual treatments are combined with new targets the antagonist pharmaceutical drugs of the adrenoceptors α2 that help to boost or increase neurotransmission existing in the brain. Given that it has been observed that in post-mortem brains of patients previously diagnosed with depression and who had committed suicide, these adrenoceptors were found to be altered, their function increased and there was a greater braking effect than normal. This braking impeded the neurotransmission systems from functioning correctly. If we stop this greater braking effect in those persons suffering depression, it could be that the anti-depressive pharmacological drug might start to act, he added.

The approach to this study involved animals using the technique of in vivo cerebral microdialysis; that is, using surgery we introduce probes in certain cerebral zones, and we collected and measured the amount of neurotransmitters in these areas, in order to subsequently see how they are modified on administering different pharmaceutical drugs.

The results of the thesis point to the fact that the new strategies proposed are able, on the one hand, of improving the percentage response as regards the number of persons responding to treatment and, on the other, of shortening the time period between the initiation of treatment and therapeutic response. Which may indicate that if all this is taken to the level of a clinical study and trials with patients suffering from depression are begun, perhaps there will be a faster response and amongst a greater number of patients he stated.


'/>"/>

Contact: Irati Kortabitarte
iratik@elhuyar.com
34-943-363-040
Elhuyar Fundazioa
Source:Eurekalert

Related medicine news :

1. Genetics May Determine Antidepressants Effectiveness
2. Antidepressants Help HIV-Infected Patients Stick to Treatment
3. Study shows new strategy for developing antidepressants
4. Antidepressants Boost GI Bleeding Risk
5. Antidepressants and painkillers - a dangerous combination
6. Newer antidepressants led to less, not more, teen suicides
7. Experimental Antidepressants Offer Faster Relief
8. Combined Boards Provide Better Care to More Clients More Efficiently
9. Using Efficient Communication to Boost Pharma Sales Force Productivity
10. Thomson Healthcare Study Finds That Hospitals Delivering High-Quality Heart Care Are Efficient and Cost Effective, Too
11. More Efficient, Effective and Personal Patient Care at New McCune-Brooks Hospital Made Possible by Siemens HiPath(R) Wireless
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/12/2017)... ... ... The American College of Medical Informatics (ACMI) will present the 2017 Morris ... of AMIA’s Annual Symposium in Washington, D.C. AMIA’s Annual Symposium is taking ... in the field of medical informatics, this prestigious award is presented to an individual ...
(Date:10/12/2017)... ... 2017 , ... Dr. Parsa Mohebi, the Los Angeles based ... the newly revamped Cosmetic Town journal section, featuring articles written by ... as Follicular Unit Extraction (FUE). , Dr. Mohebi says “I enjoy ...
(Date:10/12/2017)... (PRWEB) , ... October 12, 2017 , ... On Saturday, ... a treadmill relay – Miles by Moonlight to raise money for the American Heart ... or more. , Teams will work together to keep their treadmills moving for ...
(Date:10/12/2017)... ... October 12, 2017 , ... In ... taxes a year. In some states—like New York, New Jersey, Massachusetts, Texas, Virginia, ... overseas retirement havens have extremely low property-tax rates, which contributes to the relatively ...
(Date:10/12/2017)... ... October 12, 2017 , ... Vodori, Inc., ... promotional review platform at the Promotional Review Committee Compliance and Best Practices ... streamline the medical, legal, and regulatory review (MLR) process – which ensures ...
Breaking Medicine News(10 mins):
(Date:10/12/2017)... Oct. 12, 2017   Divoti USA will ... to the standard of the latest FDA requirements, which stipulates new ... Anyone in need of Medical ID jewelry such as Medical ... are engraved in terms of the new FDA requirements ... Divoti offers this dark ...
(Date:10/11/2017)... , Oct. 11, 2017  Hill-Rom Holdings, Inc. ("Hill-Rom") ... Surgical facility in Las Piedras, Puerto Rico ... and blades. ... the facility sustained minor structural damage, temporary loss of ... Repairs have been completed, manufacturing operations have resumed, and ...
(Date:10/4/2017)... , Oct. 4, 2017  South Korean-based healthcare product ... training aide "cprCUBE" on Kickstarter. The device will educate ... cardiac arrests with better efficiency compared to the dated ... real-time feedback on efficacy of the compression for a ... has a goal to raise $5,000. ...
Breaking Medicine Technology: